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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_0047 [new locus tag: SPT_RS00245 ]
  • pan locus tag?: PNEUPAN000368000
  • symbol: SPT_0047
  • pan gene symbol?: ftsH
  • synonym:
  • product: putative Cell division protease FtsH homolog

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_0047 [new locus tag: SPT_RS00245 ]
  • symbol: SPT_0047
  • product: putative Cell division protease FtsH homolog
  • replicon: chromosome
  • strand: +
  • coordinates: 32651..34609
  • length: 1959
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGAAAAAACAAAATAATGGTTTAATTAAAAATCCTTTTCTATGGTTATTATTTATCTTT
    TTCCTTGTGACAGGATTCCAGTATTTCTATTCTGGGAATAACTCAGGAGGAAGTCAGCAA
    ATCAACTATACTGAGTTGGTACAAGAAATTACCGATGGTAATGTAAAAGAATTAACTTAC
    CAACCAAATGGTAGTGTTATCGAAGTTTCTGGTGTCTATAAAAATCCTAAAACAAGTAAA
    GAAGGAACAGGTATTCAGTTTTTCACGCCATCTGTTACTAAGGTAGAGAAATTTACCAGC
    ACTATTCTTCCTGCAGATACTACCGTATCAGAATTGCAAAAACTTGCTACTGACCATAAA
    GCAGAAGTAACTGTTAAGCATGAAAGTTCAAGTGGTATATGGATTAATCTACTCGTATCC
    ATTGTGCCATTTGGAATTCTATTCTTCTTCCTATTCTCTATGATGGGAAATATGGGAGGA
    GGCAATGGCCGTAATCCAATGAGTTTTGGACGTAGTAAGGCTAAAGCAGCAAATAAAGAA
    GATATTAAAGTAAGATTTTCAGATGTTGCTGGAGCTGAGGAAGAAAAACAAGAACTAGTT
    GAAGTTGTTGAGTTCTTAAAAGATCCAAAACGATTCACAAAACTTGGAGCCCGTATTCCA
    GCAGGTGTTCTTTTGGAGGGACCTCCGGGGACAGGTAAGACTTTGCTTGCTAAGGCAGTC
    GCTGGAGAAGCAGGTGTTCCATTCTTTAGTATCTCAGGTTCTGACTTTGTAGAAATGTTT
    GTCGGAGTTGGAGCTAGTCGTGTTCGCTCTCTTTTTGAGGATGCCAAAAAAGCAGCACCA
    GCTATCATCTTTATCGATGAAATTGATGCTGTTGGACGTCAACGTGGAGTCGGTCTCGGC
    GGAGGTAATGACGAACGTGAACAAACCTTGAACCAACTTTTGATTGAGATGGATGGTTTT
    GAGGGAAATGAAGGGATTATCGTCATCGCTGCGACAAACCGTTCAGATGTACTTGATCCT
    GCCCTTTTGCGTCCAGGACGTTTTGATAGAAAAGTATTGGTTGGCCGTCCTGATGTTAAA
    GGTCGTGAAGCAATCTTGAAAGTTCACGCTAAGAACAAGCCTTTAGCAGAAGATGTTGAT
    TTGAAATTAGTGGCTCAACAAACTCCAGGCTTTGTTGGTGCTGATTTAGAGAATGTCTTG
    AATGAAGCAGCTTTAGTTGCTGCTCGTCGCAATAAATCGATAATTGATGCTTCAGATATT
    GATGAAGCAGAAGATAGAGTTATTGCTGGACCTTCTAAGAAAGATAAGACAGTTTCACAA
    AAAGAACGAGAATTGGTTGCTTACCATGAGGCAGGACATACCATTGTTGGTCTAGTCTTG
    TCGAATGCTCGCGTTGTCCATAAGGTTACAATTGTACCACGCGGCCGTGCAGGCGGATAC
    ATGATTGCACTTCCTAAAGAGGATCAAATGCTTCTATCTAAAGAAGATATGAAAGAGCAA
    TTGGCTGGCTTAATGGGTGGACGTGTAGCTGAAGAAATTATCTTTAATGTCCAAACTACA
    GGAGCTTCAAACGACTTTGAACAAGCGACACAAATGGCACGTGCAATGGTTACAGAGTAC
    GGTATGAGTGAAAAACTTGGCCCAGTACAATATGAAGGAAACCATGCTATGCTTGGTGCA
    CAGAGTCCTCAAAAATCAATTTCAGAACAAACAGCTTATGAAATTGATGAAGAGGTTCGT
    TCATTATTAAATGAGGCACGAAATAAAGCTGCTGAAATTATTCAGTCAAATCGTGAAACT
    CACAAGTTAATTGCAGAAGCATTATTGAAATACGAAACATTGGATAGTACACAAATTAAA
    GCTCTTTACGAAACAGGAAAGATGCCTGAAGCAGTAGAAGAGGAATCTCATGCACTATCC
    TATGATGAAGTAAAGTCAAAAATGAATGACGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1959

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_0047 [new locus tag: SPT_RS00245 ]
  • symbol: SPT_0047
  • description: putative Cell division protease FtsH homolog
  • length: 652
  • theoretical pI: 5.23691
  • theoretical MW: 71253.6
  • GRAVY: -0.26411

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.24.-?  ExPASy
  • TIGRFAM:
    Cellular processes Cellular processes Cell division ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 750.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 750.2)
    and 15 more
    26S proteasome subunit P45 family (TIGR01242; HMM-score: 267.5)
    AAA family ATPase, CDC48 subfamily (TIGR01243; HMM-score: 263.8)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides proteasome ATPase (TIGR03689; EC 3.6.4.8; HMM-score: 144.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 26.4)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 26.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 24.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 19.4)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 18.5)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides endopeptidase La (TIGR00763; EC 3.4.21.53; HMM-score: 16.1)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 14.8)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent protease HslVU, ATPase subunit (TIGR00390; HMM-score: 14.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 13.4)
    Genetic information processing Protein fate Protein folding and stabilization methylamine dehydrogenase accessory protein MauD (TIGR02661; HMM-score: 11.7)
    Metabolism Energy metabolism Amino acids and amines methylamine dehydrogenase accessory protein MauD (TIGR02661; HMM-score: 11.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 11.6)
  • TheSEED  :
    • Cell division-associated, ATP-dependent zinc metalloprotease FtsH
    Bacterial Cell Division  Cell division protein FtsH (EC 3.4.24.-)
    and 2 more
    Cell division-ribosomal stress proteins cluster  Cell division protein FtsH (EC 3.4.24.-)
    RP Bacterial Cell Division  Cell division protein FtsH (EC 3.4.24.-)
  • PFAM:
    Peptidase_MA (CL0126) Peptidase_M41; Peptidase family M41 (PF01434; HMM-score: 237.4)
    and 21 more
    P-loop_NTPase (CL0023) AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 153.2)
    AAA_lid (CL0671) AAA_lid_3; AAA+ lid domain (PF17862; HMM-score: 50.2)
    no clan defined FtsH_ext; FtsH Extracellular (PF06480; HMM-score: 39.7)
    P-loop_NTPase (CL0023) AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 22)
    TIP49; TIP49 P-loop domain (PF06068; HMM-score: 21.2)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 20.8)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 16.8)
    AAA_22; AAA domain (PF13401; HMM-score: 16.2)
    AAA_33; AAA domain (PF13671; HMM-score: 15.6)
    AAA_lid (CL0671) LonB_AAA-LID; Archaeal LonB, AAA+ ATPase LID domain (PF20436; HMM-score: 15.3)
    no clan defined RIC3; Resistance to inhibitors of cholinesterase homologue 3 (PF15361; HMM-score: 14.2)
    P-loop_NTPase (CL0023) Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 14.1)
    AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 14)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 13.9)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 13.8)
    AAA_17; AAA domain (PF13207; HMM-score: 13.7)
    AAA_18; AAA domain (PF13238; HMM-score: 13.7)
    AAA_28; AAA domain (PF13521; HMM-score: 13.4)
    AAA_30; AAA domain (PF13604; HMM-score: 13.1)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 12.8)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 9.99
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.9851
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0147
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.293595
    • TAT(Tat/SPI): 0.001468
    • LIPO(Sec/SPII): 0.15619
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO23902 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYTELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSKEGTGIQFFTPSVTKVEKFTSTILPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGGGNGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGARIPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAKKAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNRSDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFVGADLENVLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHEAGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGRVAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEGNHAMLGAQSPQKSISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYETGKMPEAVEEESHALSYDEVKSKMNDEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: RegR* (repression) regulon
    RegR*(TF)important in Hyaluronate utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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