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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_0211 [new locus tag: SPT_RS01070 ]
  • pan locus tag?: PNEUPAN000895000
  • symbol: SPT_0211
  • pan gene symbol?: hexB
  • synonym: mutL
  • product: DNA mismatch repair protein MutL

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_0211 [new locus tag: SPT_RS01070 ]
  • symbol: SPT_0211
  • product: DNA mismatch repair protein MutL
  • replicon: chromosome
  • strand: +
  • coordinates: 186941..188890
  • length: 1950
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGTCTCATATTATTGAATTGCCAGAGATGCTGGCAAACCAAATCGCGGCTGGAGAGGTC
    ATTGAACGTCCTGCCAGTGTGGTCAAAGAGTTGGTAGAAAATGCCATTGACGCGGGCTCT
    AGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGAAGGTTCAAATCACGGATAAC
    GGTCATGGAATTGCCCACGATGAGGTGGAGTTGGCCCTGCGTCGCCATGCGACCAGTAAG
    ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTG
    CCTTCTATTGCGTCTGTTAGTGTCTTGACTCTGTTAACGGCGGTGGATGGTGCTAGTCAT
    GGAACCAAGTTAGTCGCGCGCGGGGGTGAAGTTGAGGAAGTCATCCCAGCGACTAGTCCT
    GTGGGAACCAAGGTTTGTGTGGAGGATCTCTTTTTCAACACGCCTGCCCGTCTCAAGTAT
    ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTG
    GCCCATCCTGAGATTTCTTTTAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCA
    GGGACTGGTCAATTGCGCCAAGCAATCGCAGGGATTTACGGTTTGGTCAGTGCCAAGAAG
    ATGATTGAAATTGAGAACTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTGCCT
    GAGTTGACTCGGGCTAACCGCAATTATATCAGCCTCTTCATCAATGGTCGTTATATCAAG
    AACTTCCTGCTCAATCGTGCTATTTTGGATGGTTTCGGAAGCAAGCTTATGGTTGGACGT
    TTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATCTAGCGGATGTCAATGTGCAT
    CCAACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACCCTGGTTTCAGAA
    GCTATTGCAAATAGTCTCAAGGAACAAACCTTGATTCCAGATGCCTTGGAAAATCTTGCC
    AAATCGACCGTGCGCAATCGTGAGAAGGTGGATCAAACTATTCTCCCACTCAAAGAAAAT
    ACGCTCTACTATGAGAAAACTGAGCCGTCAAGACCTAGTCAAACTGAAGTAGCTGATTAT
    CAGGTAGAATTGACTGATGAAGGGCAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
    CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAG
    CTAGACCATCCAGAGTTAGATCTTGCTAGCATCGATAAGGCTTATGACAAACTGGAGCGA
    GAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGACAAATGCACGGGACTTATCTC
    TTTGCCCAAGGGCGAGATGGACTTTACATCATAGATCAGCACGCTGCTCAGGAACGGGTC
    AAGTACGAGGAGTACCGTGAAAGCATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTA
    GTGCCCTATATCTTTGAATTTCCTGCGGATGATGCCCTGCGTCTCAAGGAAAGAATGCCT
    CTCTTAGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAGAAAATCAATTTATTCTACGT
    GAACATCCTATTTGGATGGCAGAAGAAGAGATTGAATCAGGCATCTATGAGATGTGCGAC
    ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATACCGAGCAGAGCTGGCTATCATG
    ATGTCTTGCAAGCGATCTATCAAGGCCAATCATCGTATTGATGATCATTCAGCTAGACAA
    CTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACTGTCCTCACGGACGTCCTGTT
    TTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
    ACCAGTCTCCGTGAGTTGGGGAAATATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1950

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_0211 [new locus tag: SPT_RS01070 ]
  • symbol: SPT_0211
  • description: DNA mismatch repair protein MutL
  • length: 649
  • theoretical pI: 5.2991
  • theoretical MW: 73420.4
  • GRAVY: -0.304777

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA mismatch repair protein MutL (TIGR00585; HMM-score: 338.6)
    and 4 more
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 14.9)
    Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 14.9)
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 14.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase VI, B subunit (TIGR01052; EC 5.99.1.3; HMM-score: 12.1)
  • TheSEED  :
    • DNA mismatch repair protein MutL
    DNA Metabolism DNA repair DNA repair, bacterial MutL-MutS system  DNA mismatch repair protein MutL
  • PFAM:
    no clan defined MutL_C; MutL C terminal dimerisation domain (PF08676; HMM-score: 138.3)
    S5 (CL0329) DNA_mis_repair; DNA mismatch repair protein, C-terminal domain (PF01119; HMM-score: 119)
    and 3 more
    His_Kinase_A (CL0025) HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF13589; HMM-score: 37.7)
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 35.4)
    TIM_barrel (CL0036) ComA; (2R)-phospho-3-sulfolactate synthase (ComA) (PF02679; HMM-score: 14)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9934
    • Cytoplasmic Membrane Score: 0.0059
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0006
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004594
    • TAT(Tat/SPI): 0.000254
    • LIPO(Sec/SPII): 0.000437
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKYMKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPDALENLAKSTVRNREKVDQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENHTSLRELGKY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: RegR* (repression) regulon
    RegR*(TF)important in Hyaluronate utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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