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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_0326 [new locus tag: SPT_RS01655 ]
  • pan locus tag?: PNEUPAN001019000
  • symbol: SPT_0326
  • pan gene symbol?: pepC
  • synonym:
  • product: aminopeptidase C (Bleomycin hydrolase)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_0326 [new locus tag: SPT_RS01655 ]
  • symbol: SPT_0326
  • product: aminopeptidase C (Bleomycin hydrolase)
  • replicon: chromosome
  • strand: +
  • coordinates: 291591..292925
  • length: 1335
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAACGCGATTCAAGAATCATTTACTGATAAACTATTTGCCAACTATGAAGCAAATGTA
    AAATACCAAGCGATTGAAAATGCTGCCAGCCACAACGGAATTTTTGCAGCTCTGGAACGT
    CGCCAAAGCCATGTAGACAACACACCTGTTTTCTCATTGGATTTAACCAAGGACAAGGTC
    ACTAACCAGAAAGCGTCTGGTCGTTGCTGGATGTTTGCGGCTCTCAACACCTTCCGCCAC
    AAACTCATCTCGCAATACAAATTGGAGAACTTTGAGTTGTCACAAGCCCACACTTTCTTC
    TGGGATAAGTATGAGAAATCAAACTGGTTCTTGGAGCAAGTCATTGCGACTTCAGACCAA
    GAATTGACTAGCCGCAAGGTTAGCTTCTTACTCCAAACACCTCAACAAGATGGTGGTCAA
    TGGGATATGGTCGTTTCCCTCTTTGAAAAATACGGTGTCGTGCCTAAGTCAGTTTATCCT
    GAGTCTGTTTCATCTAGCAGCAGTCGTGAGCTAAATGCGATCCTTAATAAATTGCTTCGT
    CAAGATGCTCAAATCTTGCGTGATTTGCTTGTTTCTGGTGCAGATCAAGTGACTGTTCAA
    GCTAAGAAAGAAGACCTCTTGCAAGAAATCTTTAACTTTCTTGCTATGTCATTAGGACTT
    CCACCACGCAAGTTTGACTTTGCTTATCGCGATAAAGATAACAACTACAAAAGTGAAAAA
    GGAATCACACCACAAGAGTTCTACAAGAAATATGTCAATCTTCCTTTAGAAGACTACGTT
    TCTGTTATCAATGCTCCAACTGCTGATAAACCTTACGGAAAATCTTACACAGTTGAGATG
    TTGGGGAATGTGGTTGGTAGCCGTGCAGTTCGTTACATCAACGTTCCAATGGAGCGCTTG
    AAAGAATTGGCGATTGCCCAAATGCAAGCAGGTGAGACTGTTTGGTTTGGTTCTGATGTC
    GGCCAGCTCAGTAACCGTAAGGCTGGAATCCTTGCGACAGATGTTTATGACTTTGAATCA
    AGCATGGACATTAAACTTACTCAAGACAAGGCTGGACGTTTGGACTATAGCGAAAGCTTG
    ATGACCCACGCCATGGTCTTGACAGGTGTTGACTTGGACGAAAATGGTAAATCAACCAAG
    TGGAAGGTTGAAAACTCATGGGGAGACAAGGTCGGTACAGATGGTTACTTTGTTGCCTCA
    GACGCTTGGATGGACGAATACACATACCAAATCGTTGTTCGTAAGGAATTGCTGACAGCA
    GAAGAACAAGCTGCCTATGGAGCAGAACCAATTGTACTTGCACCATGGGATCCAATGGGA
    GCCTTGGCTAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1335

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_0326 [new locus tag: SPT_RS01655 ]
  • symbol: SPT_0326
  • description: aminopeptidase C (Bleomycin hydrolase)
  • length: 444
  • theoretical pI: 4.95558
  • theoretical MW: 50282.5
  • GRAVY: -0.395721

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.22.40?  ExPASy
    Bleomycin hydrolase Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred
  • TIGRFAM:
  • TheSEED  :
    • Aminopeptidase C (EC 3.4.22.40)
    Protein Metabolism Protein degradation Protein degradation  Aminopeptidase C (EC 3.4.22.40)
  • PFAM:
    Peptidase_CA (CL0125) Peptidase_C1_2; Peptidase C1-like family (PF03051; HMM-score: 689.8)
    and 4 more
    Peptidase_C1; Papain family cysteine protease (PF00112; HMM-score: 33.3)
    EAD1 (CL0699) EAD10; Effector-associated domain 10 (PF19954; HMM-score: 15.8)
    no clan defined FliT; Flagellar protein FliT (PF05400; HMM-score: 13.7)
    Peptidase_CA (CL0125) Peptidase_C10; Peptidase C10 family (PF01640; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9345
    • Cytoplasmic Membrane Score: 0.0054
    • Cell wall & surface Score: 0.0009
    • Extracellular Score: 0.0592
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.037022
    • TAT(Tat/SPI): 0.001347
    • LIPO(Sec/SPII): 0.002108
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO23120 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNAIQESFTDKLFANYEANVKYQAIENAASHNGIFAALERRQSHVDNTPVFSLDLTKDKVTNQKASGRCWMFAALNTFRHKLISQYKLENFELSQAHTFFWDKYEKSNWFLEQVIATSDQELTSRKVSFLLQTPQQDGGQWDMVVSLFEKYGVVPKSVYPESVSSSSSRELNAILNKLLRQDAQILRDLLVSGADQVTVQAKKEDLLQEIFNFLAMSLGLPPRKFDFAYRDKDNNYKSEKGITPQEFYKKYVNLPLEDYVSVINAPTADKPYGKSYTVEMLGNVVGSRAVRYINVPMERLKELAIAQMQAGETVWFGSDVGQLSNRKAGILATDVYDFESSMDIKLTQDKAGRLDYSESLMTHAMVLTGVDLDENGKSTKWKVENSWGDKVGTDGYFVASDAWMDEYTYQIVVRKELLTAEEQAAYGAEPIVLAPWDPMGALAK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: RegR* (repression) regulon
    RegR*(TF)important in Hyaluronate utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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