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serotype 4
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serotype 2
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serotype 19A
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serotype 6B
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serotype 23F
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serotype 1
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serotype 14
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serotype 19F
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serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
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serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_0366 [new locus tag: SPT_RS01855 ]
  • pan locus tag?: PNEUPAN001109000
  • symbol: SPT_0366
  • pan gene symbol?: eda
  • synonym:
  • product: keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_0366 [new locus tag: SPT_RS01855 ]
  • symbol: SPT_0366
  • product: keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase
  • replicon: chromosome
  • strand: -
  • coordinates: 331151..331780
  • length: 630
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGACCAAATCAGATACGATTATTGAACTAAAAAAACAAAAAATTGTCGCTGTTATTCGA
    GGAAATACAAAGGAAGAAGGACTGCAAGCCTCGATTGCTTGTATCAAGGGCGGTATCAAA
    GCTATTGAAATCGCCTATACCAATCAGTATGCAGGGCAAATCATCAAGCAACTTGTAGAC
    TTGTATCAGGACGATCAAAGTGTTTGTATCGGTGCAGGTACTGTGATTGATGCCGTAACT
    GCTAGAGATGCTATTCTAGCCGGAGCAAATTACGTTGTTTCTCCATCTTTCCATGCTGAA
    ACTGCAAAAATGTGCAATCTCTACAGCACACCGTACATTCCAGGCTGTATTACTCTCACA
    GAGATAACGACTGCACTTGAAGCCGGTAGTGAAATCATTAAACTCTTCCCAGGTAGTGCT
    CTCAGTCCAGCATATATCTCTGCAGTCAAGGCACCGATCCCACAAGTTTCCGTAATGGTA
    ACCGGAGGAGTCGGCCTAAACAACATTCCTCAATGGTTCGCTGCTGGTGCAGACGCCGTT
    GGAATTGGTGGCGAACTCAATAAACTCGCTTCCCAAGGCGACTTTGACCGCATCAGCGAG
    ATTGCCCAACAGTATGTTACACTCAGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    630

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_0366 [new locus tag: SPT_RS01855 ]
  • symbol: SPT_0366
  • description: keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase
  • length: 209
  • theoretical pI: 4.94715
  • theoretical MW: 22024.2
  • GRAVY: 0.236842

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (TIGR01182; EC 4.1.2.14,4.1.3.16; HMM-score: 161)
    Metabolism Energy metabolism Entner-Doudoroff 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (TIGR01182; EC 4.1.2.14,4.1.3.16; HMM-score: 161)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotate dehydrogenase (fumarate) (TIGR01036; EC 1.3.98.1; HMM-score: 14.8)
    Metabolism Energy metabolism Pentose phosphate pathway ribulose-phosphate 3-epimerase (TIGR01163; EC 5.1.3.1; HMM-score: 13.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine-phosphate diphosphorylase (TIGR00693; EC 2.5.1.3; HMM-score: 13.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate-nucleotide diphosphorylase (carboxylating) (TIGR00078; EC 2.4.2.19; HMM-score: 12.3)
  • TheSEED  :
    • 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
    • 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16)
    Carbohydrates Central carbohydrate metabolism Entner-Doudoroff Pathway  2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
    and 2 more
    Carbohydrates Central carbohydrate metabolism Glycolate, glyoxylate interconversions  4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16)
    Carbohydrates One-carbon Metabolism Formaldehyde assimilation: Ribulose monophosphate pathway  2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
  • PFAM:
    TIM_barrel (CL0036) Aldolase; KDPG and KHG aldolase (PF01081; HMM-score: 130.8)
    and 3 more
    QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 16.1)
    Ribul_P_3_epim; Ribulose-phosphate 3 epimerase family (PF00834; HMM-score: 14.8)
    DUF561; Protein of unknown function (DUF561) (PF04481; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.021587
    • TAT(Tat/SPI): 0.000383
    • LIPO(Sec/SPII): 0.004489
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO22659 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKSDTIIELKKQKIVAVIRGNTKEEGLQASIACIKGGIKAIEIAYTNQYAGQIIKQLVDLYQDDQSVCIGAGTVIDAVTARDAILAGANYVVSPSFHAETAKMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSALSPAYISAVKAPIPQVSVMVTGGVGLNNIPQWFAAGADAVGIGGELNKLASQGDFDRISEIAQQYVTLR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: RegR* (repression) regulon
    RegR*(TF)important in Hyaluronate utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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