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PangenomeTIGR4
serotype 4
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serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0199 [new locus tag: SP_RS00965 ]
  • pan locus tag?: PNEUPAN000927000
  • symbol: cls
  • pan gene symbol?: cls
  • synonym:
  • product: cardiolipin synthetase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0199 [new locus tag: SP_RS00965 ]
  • symbol: cls
  • product: cardiolipin synthetase
  • replicon: chromosome
  • strand: +
  • coordinates: 185329..186753
  • length: 1425
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGCTCCCATTTTATGGATTACTGTCCTCATTCTACTGAGTATCATCACAATCATTTCG
    ATAGTCAACCGTAATACGACTCCTGAGAATAAGGTAACCTGGTTGTTAGTAGCCTTTGTG
    CCAGTATTTGGTCCCTTGCTCTATCTGATGTTTGGTGAAAGGCGATTGTCCAAAAAAGAA
    ATCAAACAACTGAAGAAGCTAGGCTCTATGCATTTCCAAGAAGCAAATAGCCAGCTACTA
    AAAGAGAAATTAAAAGAAAGTGACAAGGCAGCTTATGGAGTCATCAAGTCCTTATTGAGT
    ATGGATACCAATGCTGACATCTATGATCAAACTGCCTCTACATTTTTTCCTAACGGAGAA
    GCTATGTGGAAAAAGATGGTAGAAGATCTTAAAAAGGCTGAGAAATTTATTTTCTTGGAA
    TATTACATTATAGAAGAAGGTTTGATGTGGAATCGCATACTAGATATACTAGAGCAAAAG
    GTAGCTCAGGGTGTAGAGGTTAAGATGCTCTATGATGATATCGGCTGTATGGCTACTTTA
    ACAGGAGATTATGCACATCGACTTCGTCAGCTGGGCATCGAGGCCCATAAATTCAATAAA
    GTTATTCCTCGTTTGACAGTGGCTTATAATAACAGAGATCATAGAAAAATATTGATTGTT
    GATGGTCAGATAGCCTATACTGGTGGGGTCAATCTGGCAGATGAGTACATTAACCACGTC
    GAGAGATTTGGTTATTGGAAGGATAGTGGAATTCGCTTAGACGGACTAGCAGTAAAAGCT
    CTGACACGCTTATTTTTGACCACTTGGTACATTAATCGAGGAGAAATTAGTGATTTTGAT
    CAATATCATTTAGAAAATCATTCTATCCCGAGTGACGGTTTAACCATTCCATACGGAAGT
    GGACCCAAGCCAATTTTTCGAGCGCAGGTAGGGAAAAAAGTTTATCAGAGTTTAATCAAT
    CAAGCAACAGAATCGGTCTATATTACGACACCTTATTTGATTATAGATTATGATTTAACA
    GAGACAATCAAAAATGCAGCTATGAGAGGGGTCGATGTTCGAATTATCACCCCTTACATA
    CCAGATAAGAAGTTCATTCAGTTAGTCACGAGAGGAGCTTATCCCGACCTTCTTTCTGCT
    GGTGTTCGGATTTATGAGTATAGTCCAGGTTTTATTCATAGTAAGCAGATGTTGGTAGAC
    GAAGATTTTGCGGTGGTGGGGACAATCAATCTCGACTACCGGAGCTTGGTACACCATTAT
    GAAAATGCAGTCTTACTCTATAAAACTCCTTCTATAAGGGAAATCGCCCGAGATTTTCGA
    AATATATTTGCAGATTCTCAGGAAGTCTATCCTCATTCTATCAAAACGAGCTGGTATCAA
    AAGCTTGTAAAAGAAATCGCCCAGCTATTCGCCCCTATCTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1425

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0199 [new locus tag: SP_RS00965 ]
  • symbol: Cls
  • description: cardiolipin synthetase
  • length: 474
  • theoretical pI: 8.59651
  • theoretical MW: 54443.8
  • GRAVY: -0.0791139

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.8.-?  ExPASy
  • TIGRFAM:
    cardiolipin synthase (TIGR04265; EC 2.7.8.-; HMM-score: 358.7)
  • TheSEED  :
    • Cardiolipin synthetase (EC 2.7.8.-)
    Fatty Acids, Lipids, and Isoprenoids Phospholipids Glycerolipid and Glycerophospholipid Metabolism in Bacteria  Cardiolipin synthetase (EC 2.7.8.-)
  • PFAM:
    PLD (CL0479) PLDc_2; PLD-like domain (PF13091; HMM-score: 126.8)
    and 4 more
    PLDc; Phospholipase D Active site motif (PF00614; HMM-score: 50.8)
    no clan defined PLDc_N; Phospholipase_D-nuclease N-terminal (PF13396; HMM-score: 43.6)
    PLD (CL0479) Regulator_TrmB; Archaeal transcriptional regulator TrmB (PF11495; HMM-score: 15.5)
    FAM83; FAM83 A-H (PF07894; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0006
    • Cytoplasmic Membrane Score: 0.9967
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0027
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.034481
    • TAT(Tat/SPI): 0.000491
    • LIPO(Sec/SPII): 0.023108
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAPILWITVLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLMFGERRLSKKEIKQLKKLGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLSMDTNADIYDQTASTFFPNGEAMWKKMVEDLKKAEKFIFLEYYIIEEGLMWNRILDILEQKVAQGVEVKMLYDDIGCMATLTGDYAHRLRQLGIEAHKFNKVIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHVERFGYWKDSGIRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPYGSGPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRGVDVRIITPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVDEDFAVVGTINLDYRSLVHHYENAVLLYKTPSIREIARDFRNIFADSQEVYPHSIKTSWYQKLVKEIAQLFAPIL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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