From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0556 [new locus tag: SP_RS02730 ]
  • pan locus tag?: PNEUPAN001434000
  • symbol: infB
  • pan gene symbol?: infB
  • synonym:
  • product: translation initiation factor IF-2

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0556 [new locus tag: SP_RS02730 ]
  • symbol: infB
  • product: translation initiation factor IF-2
  • replicon: chromosome
  • strand: +
  • coordinates: 523124..526000
  • length: 2877
  • essential: yes [1]

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    TTGTCTAAGAAAAGATTGTACGAAATCGCAAAAGAACTTGGAAAAGAAAGTAAAGAAGTT
    GTAGCGCGTGCAAAAGAGTTGGGCTTGGATGTGAAAAGCCACTCATCAAGTGTGGAAGAA
    GCTGTCGCTGCAAAAATTGCTGCCAGCTTTAAGCCTGCAGCTGCTCCGAAAGTAGAAGCA
    AAACCTGCAGCCCCAAAAGTAAGTGCAGAAAAGAAAGCCGAAAAATCTGAGCCAGCTAAA
    CCAGCTGTAGCTAAGGAAGAGGCAAAACCTGCAGCCCCAAAAGCAAGTGCAGAAAAGAAA
    GCCGAAAAGTCTGAACCAGTAAAACCAGCTGTAGCCAAGGAAGAGGCAAAACCAGCTGAG
    CCAGTCACTCCGAAAACAGAAAAAGTAGCGGCTAAACCGCAAAGTCGTAATTTCAAGGCT
    GAGCGTGAAGCACGTGCTAAAGAGCAGGCAGAGCGACGCAAGCAAAATAAGGGCAATAAC
    CGTGACCAACAACAAAACGGAAACCGTCAGAAAAACGACGGCCGTAATGGTGGAAAACAA
    GGTCAAAGCAACCGCGACAATCGTCGCTTTAATGACCAAGCTAAGAAGCAGCAAGGTCAG
    CAAAAACGTAGAAATGAGCGCCGTCAGCAAGAGGATAAACGTTCAAATCAAGCGGCTCCA
    CGTATTGACTTTAAAGCCCGTGCAGCAGCCCTAAAAGCAGAGCAAAATGCAGAGTACGCT
    CGTTCAAGTGAGGAACGCTTCAAGCAGTATCAGGCTGCTAAAGAAGCCTTGGCTCAAGCT
    AACAAACGCAAGGAACCAGAGGAAATCTTTGAAGAAGCGGCTAAGTTAGCTGAACAAGCA
    CAGCAAGTTCAAGCAGTGGTTGAAGTCGTCCCTGAGAAAAAAGAACCTGCAGTGGATACA
    CGTCGTAAAAAACAAGCTCGACCAGACAAAAATCGTGACGATTATGATCATGAAGAAGAT
    GGTCCTAGAAAACAACAAAAGAATCGAAGTAGTCAAAATCAAGTGAGAAATCAAAAGAAT
    AGTAACTGGAATAACAACAAAAAGAACAAAAAAGGCAATAACAAGAACAACCGTAATCAG
    ACTCCAAAACCTGTTACGGAGCGTAAATTCCATGAATTGCCAACAGAATTTGAATATACA
    GATGGTATGACCGTTGCGGAAATCGCAAAACGTATCAAACGTGAACCAGCTGAAATTGTT
    AAGAAACTTTTCATGATGGGTGTCATGGCCACACAAAACCAATCCTTGGATGGGGAAACA
    ATTGAACTCCTCATGGTGGATTACGGTATCGAAGCCAAACAAAAGGTTGAAGTGGATAAT
    GCTGACATCGAACGTTTCTTTGTCGAAGATGGTTATCTCAATGAAGATGAATTGGTTGAG
    CGTCCACCAGTTGTTACTATCATGGGACACGTTGACCACGGTAAAACAACCCTTTTGGAT
    ACTCTTCGTAACTCACGTGTTGCGACAGGTGAAGCAGGTGGTATTACTCAGCATATCGGT
    GCCTACCAAATCGTGGAAAATGGTAAGAAGATTACCTTCCTTGATACACCAGGACACGCG
    GCCTTTACATCAATGCGTGCGCGTGGTGCTTCTGTTACCGATATTACGATCTTGGTCGTA
    GCGGCAGATGACGGGGTTATGCCTCAGACTATTGAAGCCATCAACCACTCAAAAGCAGCT
    AACGTTCCAATCATCGTAGCTATTAACAAGATTGATAAACCAGGTGCTAACCCAGAACGC
    GTTATCGGTGAATTGGCAGAGCATGGTGTGATGTCAACTGCTTGGGGTGGAGATTCTGAA
    TTTGTTGAAATTTCGGCTAAATTCAACCAAAATATCGAAGAATTGTTGGAAACAGTCCTT
    CTTGTGGCTGAAATCCAAGAACTCAAAGCAGACCCAACAGTTCGTGCGATCGGTACGGTT
    ATCGAAGCGCGCTTGGATAAAGGAAAAGGTGCGGTCGCAACCCTTCTTGTACAACAAGGT
    ACCTTGAATGTTCAAGACCCAATCGTTGTCGGAAATACCTTCGGTCGTGTCCGTGCTATG
    ACCAACGACCTTGGTCGTCGTGTTAAAGTTGCTGGACCATCAACACCAGTCTCTATCACA
    GGTTTGAACGAAGCACCGATGGCGGGTGACCACTTTGCCGTTTACGAGGATGAAAAATCT
    GCGCGTGCAGCAGGTGAAGAGCGTGCCAAACGTGCCCTCATGAAACAACGTCAAGCTACC
    CAACGTGTTAGCCTTGAAAACCTCTTTGATACCCTTAAAGCTGGGGAACTCAAATCTGTT
    AATGTTATCATCAAGGCTGATGTACAAGGTTCTGTTGAAGCCCTTTCTGCCTCACTTCAA
    AAGATTGACGTGGAAGGTGTCAAAGTGACTATCGTCCACTCAGCGGTCGGTGCTATCAAC
    GAATCAGACGTGACCCTTGCCGAAGCTTCAAATGCCTTTATCGTTGGTTTCAACGTACGC
    CCTACACCACAAGCTCGTCAACAAGCAGAAGCTGACGATGTGGAAATCCGTCTTCACAGC
    ATTATCTACAAGGTTATCGAAGAGATGGAAGAAGCTATGAAAGGGATGCTTGATCCAGAA
    TTTGAAGAAAAAGTTATTGGTGAAGCGGTTATCCGTGAAACCTTCAAGGTGTCTAAAGTG
    GGAACTATCGGTGGATTTATGGTTATCAACGGTAAGGTTGCCCGTGACTCTAAAGTCCGT
    GTTATCCGTGATGGTGTCGTTATCTATGATGGTGAACTCGCAAGCTTGAAACACTATAAA
    GACGACGTGAAAGAAGTGACAAACGGTCGTGAAGGTGGATTGATGATCGACGGCTACAAT
    GATATTAAGATGGATGATGTGATTGAGGCGTATGTCATGGAAGAAATCAAGAGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2877

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0556 [new locus tag: SP_RS02730 ]
  • symbol: InfB
  • description: translation initiation factor IF-2
  • length: 958
  • theoretical pI: 9.47556
  • theoretical MW: 105809
  • GRAVY: -0.719937

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Translation factors translation initiation factor IF-2 (TIGR00487; HMM-score: 822.1)
    and 18 more
    Genetic information processing Protein synthesis Translation factors translation initiation factor aIF-2 (TIGR00491; HMM-score: 169.1)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 121.2)
    Genetic information processing Protein synthesis Translation factors selenocysteine-specific translation elongation factor (TIGR00475; HMM-score: 100.9)
    Unknown function General elongation factor 4 (TIGR01393; EC 3.6.5.-; HMM-score: 70.7)
    Cellular processes Cellular processes Adaptations to atypical conditions GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 61.9)
    Genetic information processing Protein synthesis Translation factors GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 61.9)
    Signal transduction Regulatory functions Other GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 61.9)
    translation initiation factor 2, gamma subunit (TIGR03680; HMM-score: 50.4)
    Genetic information processing Protein synthesis Translation factors translation elongation factor G (TIGR00484; HMM-score: 46.6)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 41)
    Genetic information processing Protein synthesis Translation factors translation elongation factor Tu (TIGR00485; HMM-score: 40.1)
    Genetic information processing Protein synthesis Translation factors peptide chain release factor 3 (TIGR00503; HMM-score: 36.9)
    Genetic information processing Protein synthesis Translation factors translation elongation factor EF-1, subunit alpha (TIGR00483; HMM-score: 33.2)
    Metabolism Central intermediary metabolism Sulfur metabolism sulfate adenylyltransferase, large subunit (TIGR02034; EC 2.7.7.4; HMM-score: 33.2)
    Genetic information processing Protein synthesis Translation factors translation elongation factor aEF-2 (TIGR00490; HMM-score: 32.2)
    Genetic information processing Protein fate Protein modification and repair [FeFe] hydrogenase H-cluster maturation GTPase HydF (TIGR03918; HMM-score: 27.8)
    Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 15.2)
    Metabolism Energy metabolism Amino acids and amines ethanolamine utilization protein, EutP (TIGR02528; HMM-score: 14.8)
  • TheSEED  :
    • Translation initiation factor 2
    Protein Metabolism Protein biosynthesis Translation initiation factors bacterial  Translation initiation factor 2
    and 1 more
    Protein Metabolism Protein biosynthesis Universal GTPases  Translation initiation factor 2
  • PFAM:
    no clan defined IF-2; Translation-initiation factor 2 (PF11987; HMM-score: 138.9)
    P-loop_NTPase (CL0023) GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 124)
    and 12 more
    HTH (CL0123) IF2_N; Translation initiation factor IF-2, N-terminal region (PF04760; HMM-score: 103.5)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 45.1)
    Ras; Ras family (PF00071; HMM-score: 28.4)
    Arf; ADP-ribosylation factor family (PF00025; HMM-score: 24.9)
    SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 23.3)
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 21.8)
    EFTPs (CL0575) GTP_EFTU_D2; Elongation factor Tu domain 2 (PF03144; HMM-score: 17.8)
    P-loop_NTPase (CL0023) Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 17)
    no clan defined MMR_HSR1_Xtn; C-terminal region of MMR_HSR1 domain (PF16897; HMM-score: 16.3)
    P-loop_NTPase (CL0023) PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 14.5)
    HTH (CL0123) HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 14.4)
    HTH_PafC; PafC helix-turn-helix domain (PF19187; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9897
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0101
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.020699
    • TAT(Tat/SPI): 0.014799
    • LIPO(Sec/SPII): 0.002859
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAAKIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAAPKASAEKKAEKSEPVKPAVAKEEAKPAEPVTPKTEKVAAKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNRRFNDQAKKQQGQQKRRNERRQQEDKRSNQAAPRIDFKARAAALKAEQNAEYARSSEERFKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKKQARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTPKPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGETIELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTAWGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGDHFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADVQGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQARQQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIGGFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDIKMDDVIEAYVMEEIKR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SP_0556&oldid=2775"