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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_1113 [new locus tag: SP_RS05510 ]
- pan locus tag?: PNEUPAN002251000
- symbol: hup
- pan gene symbol?: hlpA
- synonym:
- product: DNA-binding protein HU
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_1113 [new locus tag: SP_RS05510 ]
- symbol: hup
- product: DNA-binding protein HU
- replicon: chromosome
- strand: +
- coordinates: 1042099..1042374
- length: 276
- essential: yes [1] DEG
⊟Accession numbers[edit | edit source]
- Location: AE005672 (1042099..1042374) NCBI
- BioCyc:
- MicrobesOnline: 116583 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_0997 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241ATGGCAAACAAACAAGATTTGATCGCTAAAGTAGCAGAAGCTACAGAATTGACTAAGAAA
GACTCAGCAGCAGCAGTTGAAGCTGTATTTGCAGCAGTAGCTGACTATCTTGCAGCTGGT
GAAAAAGTTCAATTGATCGGTTTTGGTAACTTTGAAGTTCGTGAGCGCGCAGAACGTAAA
GGTCGCAACCCACAAACTGGTAAAGAAATGACAATTGCAGCTTCTAAAGTACCAGCATTC
AAAGCTGGTAAAGCTCTTAAAGACGCTGTTAAATAA60
120
180
240
276
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_1113 [new locus tag: SP_RS05510 ]
- symbol: Hup
- description: DNA-binding protein HU
- length: 91
- theoretical pI: 10.2074
- theoretical MW: 9650.07
- GRAVY: -0.241758
⊟Function[edit | edit source]
- TIGRFAM: DNA metabolism DNA replication, recombination, and repair integration host factor, beta subunit (TIGR00988; HMM-score: 77.3)DNA metabolism DNA replication, recombination, and repair integration host factor, alpha subunit (TIGR00987; HMM-score: 75.6)and 1 moreDNA metabolism Chromosome-associated proteins putative DNA-binding protein (TIGR01201; HMM-score: 23.3)
- TheSEED :
- DNA-binding protein HBsu
- PFAM: IHF-likeDNA-bdg (CL0548) Bac_DNA_binding; Bacterial DNA-binding protein (PF00216; HMM-score: 116.4)and 7 moreHU-HIG; HU domain fused to wHTH, Ig, or Glycine-rich motif (PF18291; HMM-score: 34.3)no clan defined DUF2267; Uncharacterized conserved protein (DUF2267) (PF10025; HMM-score: 18.7)IHF-likeDNA-bdg (CL0548) HU-CCDC81_euk_2; CCDC81 eukaryotic HU domain 2 (PF18289; HMM-score: 14.8)HU-DNA_bdg; DNA-binding domain (PF14848; HMM-score: 14.2)no clan defined ADP_ribosyl_GH; ADP-ribosylglycohydrolase (PF03747; HMM-score: 12.9)IHF-likeDNA-bdg (CL0548) HU-CCDC81_bac_2; CCDC81-like prokaryotic HU domain 2 (PF18175; HMM-score: 12.3)no clan defined Rpf1_C; Resuscitation-promoting factor Rpf1, C-terminal (PF11574; HMM-score: 9.8)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.67
- Cytoplasmic Membrane Score: 0.01
- Cellwall Score: 0.15
- Extracellular Score: 0.17
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9563
- Cytoplasmic Membrane Score: 0.0006
- Cell wall & surface Score: 0.0002
- Extracellular Score: 0.0429
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.004297
- TAT(Tat/SPI): 0.001455
- LIPO(Sec/SPII): 0.000635
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQLIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site: 1042066 [2]
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0997 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
Nucleic Acids Res: 2002, 30(14);3152-62
[PubMed:12136097] [WorldCat.org] [DOI] (I p) - ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)