From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1446 [new locus tag: SP_RS07105 ]
  • pan locus tag?: PNEUPAN002729000
  • symbol: SP_1446
  • pan gene symbol?: nagR
  • synonym:
  • product: transcriptional regulator, GntR family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1446 [new locus tag: SP_RS07105 ]
  • symbol: SP_1446
  • product: transcriptional regulator, GntR family
  • replicon: chromosome
  • strand: +
  • coordinates: 1366429..1367136
  • length: 708
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    GTGAAAAATATGCTACCTGCTTATATAAAAATCCATGATCAGATAAAAAAGGATATTGAC
    GAGTACCGTTGGGCTATTGGTGAGAGGCTTCCCAGTGAAAGAGATTTAGCTGAGCAGTTT
    GCGGTCAGTCGCATGACCCTCCGCCAAGCCGTATCTCTATTAGTCGAAGAAGGCGTCTTA
    GAGCGCCGTGTAGGAAGCGGCACCTTTGTTTCCAGTACTCGAGTACAAGAAAAGATGCGA
    GGGACAACCAGTTTTACTGAAATTGTCAAATCCCAAGGTAAAGTTCCCTCTAGCCAGCTC
    ATTTCCTACAAAAAAACCATTCCCAATGAGCAAGAAGTTGCCAAGCTAGGAATTTTTCCA
    ACGGACAATATTATCCGAATGGAGCGGGTCCGCTATGCCGACCAAGTTCCCCTAGTTTAT
    GAAGTTGCTTCTATTCCTGAAAAATTCATTAAGGACTTTAAAAAAGAAGAAATCACCAGT
    CATTTCTTCCAAACCTTGCAAAAACATGGCTATCGTATCGGCAAATCTCAACAGACCATC
    TATGCTCGCCTTGCTAAAGAAAAGATTGCCCACTATTTGGAAGTTGAAAAAGGACATGCT
    ATTCTTGGATTGACCCAGGTTTCCTACCTAGAAGATGGTACTGCTTTTGAATACGTAAAA
    AGTCAATATGTAGGCGAACGCTTTGAATTTTATCTTGAAAATAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    708

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1446 [new locus tag: SP_RS07105 ]
  • symbol: SP_1446
  • description: transcriptional regulator, GntR family
  • length: 235
  • theoretical pI: 9.28171
  • theoretical MW: 27211
  • GRAVY: -0.46766

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Anions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 126.5)
    Signal transduction Regulatory functions DNA interactions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 126.5)
    Metabolism Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 120)
    Signal transduction Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 120)
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02404; HMM-score: 119.7)
    Signal transduction Regulatory functions DNA interactions phosphonate utilization transcriptional regulator PhnR (TIGR03337; HMM-score: 115)
    and 4 more
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 26.2)
    Metabolism Fatty acid and phospholipid metabolism Degradation fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 26.2)
    Signal transduction Regulatory functions DNA interactions fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 26.2)
    phosphonate utilization associated transcriptional regulator (TIGR03338; HMM-score: 19.2)
  • TheSEED  :
    • Transcriptional regulator in cluster with beta-lactamase, GntR family
    Beta-lactamase cluster in Streptococcus  Transcriptional regulator in cluster with beta-lactamase, GntR family
  • PFAM:
    UTRA (CL0122) UTRA; UTRA domain (PF07702; HMM-score: 127.8)
    and 8 more
    HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 77.3)
    HTH_41; Helix-turn-helix domain (PF14502; HMM-score: 22.7)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 18.9)
    HTH_11; HTH domain (PF08279; HMM-score: 18.5)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 15.6)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 14.3)
    MarR_2; MarR family (PF12802; HMM-score: 14.2)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 13.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effector: N-acetylglucosamine-6-phosphate
  • genes regulated by NagR*, TF important in N-acetylglucosamine utilizationRegPrecise
    repression
    glmS
    nagB
    nagA

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9986
    • Cytoplasmic Membrane Score: 0.0006
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0007
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007289
    • TAT(Tat/SPI): 0.000332
    • LIPO(Sec/SPII): 0.000532
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKNMLPAYIKIHDQIKKDIDEYRWAIGERLPSERDLAEQFAVSRMTLRQAVSLLVEEGVLERRVGSGTFVSSTRVQEKMRGTTSFTEIVKSQGKVPSSQLISYKKTIPNEQEVAKLGIFPTDNIIRMERVRYADQVPLVYEVASIPEKFIKDFKKEEITSHFFQTLQKHGYRIGKSQQTIYARLAKEKIAHYLEVEKGHAILGLTQVSYLEDGTAFEYVKSQYVGERFEFYLENN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SP_1446&oldid=3667"