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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_1463 [new locus tag: SP_RS07190 ]
- pan locus tag?: PNEUPAN002746000
- symbol: ogt
- pan gene symbol?: ogt
- synonym:
- product: methylated-DNA--protein-cysteine S-methyltransferase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_1463 [new locus tag: SP_RS07190 ]
- symbol: ogt
- product: methylated-DNA--protein-cysteine S-methyltransferase
- replicon: chromosome
- strand: -
- coordinates: 1377651..1378181
- length: 531
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: AE005672 (1377651..1378181) NCBI
- BioCyc:
- MicrobesOnline: 116916 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_1292 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241
301
361
421
481ATGCAAAAGAAGTATGTAAAAATCCTCTACTCCTCACCAATTGGTATTCTATCACTTGTA
GCTGATGACCATTATTTGTATGGAATTTGGGTTCAGGAGCAGAAGCATTTTGAGAGGGGA
CTAGGAGATGAAACGATAGAAGAAGTTGTTAGTCATCCTATTTTAGACCCAGTTATTGCT
TGCTTAGATGATTACTTTAAAGGCAAGCCTCAGGATTTATCCAACTTGCTCTTGGCGCCA
ATCGGAACGAATTTTGAAAAGAGAGTTTGGGACTATTTACAGGGCATTCCTTATGGTCAG
ACAGTGACCTATGGACAAATTGCTCAAGACCTGCAAGTGGCTTCTGCTCAAGCAATTGGT
GGAGCAGTGGGACGCAATCCTTGGTCTATCCTAGTACCTTGTCATCGTGTGTTGGGAGCA
GGCAAGCGTCTGACAGGTTATGCTGCAGGAGTGGAAAAGAAAGCTTGGCTCTTGGAGCAT
GAAGGAGTAGATTTTAAAGATAGAAGCAATAGAAGGAGAAGCACATGTTAG60
120
180
240
300
360
420
480
531
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_1463 [new locus tag: SP_RS07190 ]
- symbol: Ogt
- description: methylated-DNA--protein-cysteine S-methyltransferase
- length: 176
- theoretical pI: 7.54934
- theoretical MW: 19700.4
- GRAVY: -0.234659
⊟Function[edit | edit source]
- reaction: EC 2.1.1.63? ExPASyMethylated-DNA--[protein]-cysteine S-methyltransferase DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
- TIGRFAM: DNA metabolism DNA replication, recombination, and repair methylated-DNA--[protein]-cysteine S-methyltransferase (TIGR00589; EC 2.1.1.63; HMM-score: 98.6)
- TheSEED :
- Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63)
- PFAM: HTH (CL0123) DNA_binding_1; 6-O-methylguanine DNA methyltransferase, DNA binding domain (PF01035; HMM-score: 106.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: unknown (no significant prediction)
- Cytoplasmic Score: 2.5
- Cytoplasmic Membrane Score: 2.5
- Cellwall Score: 2.5
- Extracellular Score: 2.5
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9918
- Cytoplasmic Membrane Score: 0.0031
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.005
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.058855
- TAT(Tat/SPI): 0.000426
- LIPO(Sec/SPII): 0.039999
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MQKKYVKILYSSPIGILSLVADDHYLYGIWVQEQKHFERGLGDETIEEVVSHPILDPVIACLDDYFKGKPQDLSNLLLAPIGTNFEKRVWDYLQGIPYGQTVTYGQIAQDLQVASAQAIGGAVGRNPWSILVPCHRVLGAGKRLTGYAAGVEKKAWLLEHEGVDFKDRSNRRRSTC
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: SP_1462 < ogt < SP_1464
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1292 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ 1.0 1.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)