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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1504 [new locus tag: SP_RS07405 ]
  • pan locus tag?: PNEUPAN002786000
  • symbol: SP_1504
  • pan gene symbol?: bepA
  • synonym:
  • product: TPR domain protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1504 [new locus tag: SP_RS07405 ]
  • symbol: SP_1504
  • product: TPR domain protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1412458..1413669
  • length: 1212
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGTTACAGGCTTTGGAGGAGCAAGATTTAACTAAGGCTGAGCATTATTTCGCCAAAGCT
    TTAGAAAATGATTCAAGTGATCTTCTGTATGAATTGGCAACTTATCTTGAAGGGATTGGT
    TTCTATCCTCAGGCCAAGGAAATTTACCTGAAAATTGTAGAGGATTTTCCAGAGGTTCAT
    CTTAATCTAGCTGCAATTGCTAGCGAGGATGGTCAAATAGAAGAAGCCTTTACCTATCTT
    GAGGAAATCCAAGCTGACAGTGACTGGTATGTCTCGTCTTTGGCTCTGAAGGCAGACCTT
    TACCAGCTGGAAGGTTTGACAGATGTGGCACGTGAGAAATTATTGGAGGCCTTGACCTAC
    TCAGAGGATTCTCTCTTGATATTGGGTTTGGCAGAGTTGGATAGTGAGTTGGAAAATTAC
    CAAGCGGCTATTCAAGCCTATGCCCAGTTAGATAATCGCTCGATTTATGAGCAAACGGGC
    ATTTCCACCTATCAACGAATTGGCTTTGCCTATGCTCAGTTAGGGAAATTTGAAACGGCT
    ACTGAGTTTTTAGAAAAAGCCCTGGAGTTAGAATACGATGACTTAACAGCTTTTGAGTTG
    GCCAGTCTTTATTTTGATCAAGAAGAATATCAAAAAGCCACCCTCTACTTTAAGCAGCTT
    GATACCATTTCTCCTGACTTTGAAGGCTATGAGTATGGGTACAGTCAGGCTTTACATAAG
    GAACATCAAGTTCAAGAAGCCCTGCGTATCGCTAAGCAAGGATTAGAGAAAAATCCCTTT
    GAAACTCGCCTCTTGCTAGCTGCTTCACAATTTTCTTATGAATTGCATGATGCTAGTGGT
    GCAGAAAATTATCTCCTTACTGCAAAAGAAGACGCTGAGGATACAGAAGAAATCTTGCTT
    CGTTTAGCCACTATTTATCTGGAGCAGGAGCGTTATGAGGATATTCTAGAATTGCAGAGT
    GAGGAGCCAGAAAATCTTTTGACCAAGTGGATGATTGCTCGTTCTTATCAAGAAATGGAC
    GATTTGGATACTGCTTATGAGTATTATCAAGAGTTGACAGGAGATTTGAAGGACAATCCA
    GAATTTCTGGAACACTATATCTATCTCTTGCGTGAATTGGGACATTTTGAAGAAGCAAAA
    GTCCATGCTCACACTTACTTAAAACTGGTTCCAGATGATGTGCAAATGCAAGAACTGTTT
    GAGAGATTGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1212

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1504 [new locus tag: SP_RS07405 ]
  • symbol: SP_1504
  • description: TPR domain protein
  • length: 403
  • theoretical pI: 3.9099
  • theoretical MW: 46820.6
  • GRAVY: -0.429032

⊟Function[edit | edit source]

  • TIGRFAM:
    putative PEP-CTERM system TPR-repeat lipoprotein (TIGR02917; HMM-score: 57.9)
    and 7 more
    type IV pilus biogenesis/stability protein PilW (TIGR02521; HMM-score: 42.9)
    type III secretion low calcium response chaperone LcrH/SycD (TIGR02552; HMM-score: 22.9)
    tol-pal system protein YbgF (TIGR02795; HMM-score: 22.1)
    Unknown function General heme biosynthesis-associated TPR protein (TIGR00540; HMM-score: 20.8)
    poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA (TIGR03939; HMM-score: 19.5)
    FimV C-terminal domain (TIGR03504; HMM-score: 12.3)
    putative peptide modification system cyclase (TIGR04510; HMM-score: 10.9)
  • TheSEED  :
    • TPR-repeat-containing protein
  • PFAM:
    TPR (CL0020) TPR_8; Tetratricopeptide repeat (PF13181; HMM-score: 65.5)
    TPR_2; Tetratricopeptide repeat (PF07719; HMM-score: 63.1)
    TPR_19; Tetratricopeptide repeat (PF14559; HMM-score: 61.1)
    TPR_1; Tetratricopeptide repeat (PF00515; HMM-score: 56.2)
    and 19 more
    TPR_14; Tetratricopeptide repeat (PF13428; HMM-score: 50.5)
    TPR_7; Tetratricopeptide repeat (PF13176; HMM-score: 39.9)
    TPR_12; Tetratricopeptide repeat (PF13424; HMM-score: 39.5)
    TPR_16; Tetratricopeptide repeat (PF13432; HMM-score: 35.4)
    TPR_21; Tetratricopeptide repeat-like domain (PF09976; HMM-score: 23.8)
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3 (PF12895; HMM-score: 23.1)
    TPR_6; Tetratricopeptide repeat (PF13174; HMM-score: 22.9)
    TPR_17; Tetratricopeptide repeat (PF13431; HMM-score: 21.9)
    TPR_10; Tetratricopeptide repeat (PF13374; HMM-score: 19.4)
    TPR_4; Tetratricopeptide repeat (PF07721; HMM-score: 18.8)
    Fis1_TPR_C; Fis1 C-terminal tetratricopeptide repeat (PF14853; HMM-score: 18.3)
    PPR; PPR repeat (PF01535; HMM-score: 15)
    TPR_11; TPR repeat (PF13414; HMM-score: 13.8)
    TPR_9; Tetratricopeptide repeat (PF13371; HMM-score: 13.2)
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23 (PF04049; HMM-score: 11.1)
    Wzy_C_2; Virulence factor membrane-bound polymerase, C-terminal (PF11846; HMM-score: 10.6)
    TPR_3; Tetratricopeptide repeat (PF07720; HMM-score: 8)
    Sel1; Sel1 repeat (PF08238; HMM-score: 7.8)
    SHNi-TPR; SHNi-TPR (PF10516; HMM-score: 7.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8207
    • Cytoplasmic Membrane Score: 0.0892
    • Cell wall & surface Score: 0.0428
    • Extracellular Score: 0.0473
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001395
    • TAT(Tat/SPI): 0.000199
    • LIPO(Sec/SPII): 0.000236
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLQALEEQDLTKAEHYFAKALENDSSDLLYELATYLEGIGFYPQAKEIYLKIVEDFPEVHLNLAAIASEDGQIEEAFTYLEEIQADSDWYVSSLALKADLYQLEGLTDVAREKLLEALTYSEDSLLILGLAELDSELENYQAAIQAYAQLDNRSIYEQTGISTYQRIGFAYAQLGKFETATEFLEKALELEYDDLTAFELASLYFDQEEYQKATLYFKQLDTISPDFEGYEYGYSQALHKEHQVQEALRIAKQGLEKNPFETRLLLAASQFSYELHDASGAENYLLTAKEDAEDTEEILLRLATIYLEQERYEDILELQSEEPENLLTKWMIARSYQEMDDLDTAYEYYQELTGDLKDNPEFLEHYIYLLRELGHFEEAKVHAHTYLKLVPDDVQMQELFERL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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