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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1837 [new locus tag: SP_RS09110 ]
  • pan locus tag?: PNEUPAN003355000
  • symbol: SP_1837
  • pan gene symbol?: aatB
  • synonym:
  • product: putative capsular polysaccharide biosynthesis protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1837 [new locus tag: SP_RS09110 ]
  • symbol: SP_1837
  • product: putative capsular polysaccharide biosynthesis protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1746322..1747548
  • length: 1227
  • essential: yes [1] DEG

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGCCAAATTACAATATTCCATTTTCACCGCCTGATATCACAGAAGCAGAAATTACTGAA
    GTAGTGGATACCCTGCGTTCTGGTTGGATCACAACAGGTCCTAAAACAAAAGAACTGGAG
    CGCCGCTTGTCTCTTTACACACAGACACCTAAGACTGTTTGTCTCAACTCTGCGACAGCC
    GCTCTGGAGTTGATTTTACGCGTTTTGGAAGTGGGACCTGGTGATGAAGTCATCGTTCCA
    GCCATGACCTATACGGCTTCATGTAGTGTCATTACGCACGTGGGAGCAACCCCTGTCATG
    GTGGATATCCAAGCAGATACGTTTGAGATGGACTATGACCTGCTTGAGCAAGCTATCACT
    GAGAAAACTAAGGTGATTATTCCAGTAGAGCTCGCAGGGATTGTTTGCGATTATGACCGT
    TTGTTCCAAGTCGTGGAGAAAAAACGTGACTTCTTTACCGCTTCAAGCAAGTGGCAAAAG
    GCCTTTAACCGTATTGTCATTGTCTCTGATAGTGCCCACGCTTTGGGATCTATTTATAAA
    GGACAACCTTCTGGTTCTATCGCTGACTTTACTTCCTTCTCATTCCATGCAGTTAAGAAC
    TTTACAACGGCAGAAGGTGGAAGTGCGACTTGGAAAGCCAATCCAGTGATTGATGACGAA
    GAGATGTACAAGGAATTCCAAATCCTTTCCCTTCACGGGCAAACTAAGGATGCTCTTGCC
    AAGATGCAACTGGGGTCATGGGAATACGATATCGTTACACCAGCCTATAAGTGCAACATG
    ACCGATATCATGGCTTCACTTGGTTTGGTACAATTGGACCGCTATCCAAGTTTGTTGCAA
    CGCCGTAAGGACATTGTGGACCGCTATGATAGTGGTTTTGCAGGTTCTCGCATCCATCCT
    TTGGCACACAAGACTGAAACTGTCGAATCTTCACGCCACCTCTACATCACCCGTGTAGAA
    GGAGCAAGCCTAGAAGAACGCAACCTCATCATCCAAGAATTGGCTAAAGCAGGAATTGCA
    AGTAATGTTCACTACAAACCGCTTCCTCTCTTGACAGCCTATAAGAATCTTGGATTTGAT
    ATGACGAACTATCCTAAGGCCTATGCCTTCTTTGAGAATGAAATTACCCTCCCTCTTCAT
    ACTAAATTAAGCGATGAAGAAGTAGACTATATCATTGAGACTTTCAAAACAGTTTCTGAA
    AAAGTGCTAACTTTATCAAAAAAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1227

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1837 [new locus tag: SP_RS09110 ]
  • symbol: SP_1837
  • description: putative capsular polysaccharide biosynthesis protein
  • length: 408
  • theoretical pI: 5.19337
  • theoretical MW: 45675.9
  • GRAVY: -0.155882

⊟Function[edit | edit source]

  • TIGRFAM:
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase (TIGR03588; EC 2.6.1.92; HMM-score: 306.7)
    and 10 more
    aminotransferase, LLPSF_NHT_00031 family (TIGR04181; HMM-score: 169.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides TDP-4-keto-6-deoxy-D-glucose transaminase (TIGR02379; HMM-score: 162)
    dTDP-4-dehydro-6-deoxyglucose aminotransferase (TIGR04427; EC 2.-.-.-; HMM-score: 113.4)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 24.9)
    cystathionine beta-lyase (TIGR01329; EC 4.4.1.8; HMM-score: 18.3)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 17.6)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 17.4)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 14.1)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 13.5)
    Metabolism Energy metabolism Amino acids and amines methionine gamma-lyase (TIGR01328; EC 4.4.1.11; HMM-score: 13)
  • TheSEED  :
    • UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC 2.6.1.-)
  • PFAM:
    PLP_aminotran (CL0061) DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 309.9)
    and 2 more
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 34.9)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 22)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9885
    • Cytoplasmic Membrane Score: 0.0012
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0103
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02108
    • TAT(Tat/SPI): 0.005068
    • LIPO(Sec/SPII): 0.000637
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MPNYNIPFSPPDITEAEITEVVDTLRSGWITTGPKTKELERRLSLYTQTPKTVCLNSATAALELILRVLEVGPGDEVIVPAMTYTASCSVITHVGATPVMVDIQADTFEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVEKKRDFFTASSKWQKAFNRIVIVSDSAHALGSIYKGQPSGSIADFTSFSFHAVKNFTTAEGGSATWKANPVIDDEEMYKEFQILSLHGQTKDALAKMQLGSWEYDIVTPAYKCNMTDIMASLGLVQLDRYPSLLQRRKDIVDRYDSGFAGSRIHPLAHKTETVESSRHLYITRVEGASLEERNLIIQELAKAGIASNVHYKPLPLLTAYKNLGFDMTNYPKAYAFFENEITLPLHTKLSDEEVDYIIETFKTVSEKVLTLSKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)    Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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