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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_1968 [new locus tag: SP_RS09895 ]
- pan locus tag?: PNEUPAN003586000
- symbol: coaD
- pan gene symbol?: coaD
- synonym:
- product: phosphopantetheine adenylyltransferase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_1968 [new locus tag: SP_RS09895 ]
- symbol: coaD
- product: phosphopantetheine adenylyltransferase
- replicon: chromosome
- strand: -
- coordinates: 1875870..1876358
- length: 489
- essential: yes [1] DEG
⊟Accession numbers[edit | edit source]
- Location: AE005672 (1875870..1876358) NCBI
- BioCyc:
- MicrobesOnline: 117394 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_1766 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241
301
361
421
481ATGTCAGATAAGATTGGCTTATTCACAGGCTCATTTGATCCGATGACAAATGGGCATCTG
GATATCATTGAACGGGCGAGCAGACTTTTTGATAAGCTTTATGTGGGTATTTTTTTTAAT
CCCCACAAACAAGGATTTCTCCCTCTTGAAAATCGTAAACGGGGGTTAGAAAAGGCTGTG
AAACATTTGGGAAATGTTAAAGTCGTGTCTTCTCATGATAAATTGGTGGTCGATGTCGCA
AAAAGACTGGGGGCTACTTGCCTAGTGCGAGGTTTGAGAAATGCGTCGGATTTGCAATAT
GAAGCCAGTTTTGATTACTACAATCATCAGCTGTCTTCTGATATAGAGACTATTTATTTA
CATAGTCGACCTGAACATCTCTATATCAGTTCATCAGGCGTTAGAGAGCTTTTGAAGTTT
GGTCAGGATATTGCCTGCTATGTTCCCGAGAGTATTTTGGAGGAAATAAGAAATGAAAAA
AAAGATTAG60
120
180
240
300
360
420
480
489
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_1968 [new locus tag: SP_RS09895 ]
- symbol: CoaD
- description: phosphopantetheine adenylyltransferase
- length: 162
- theoretical pI: 7.69836
- theoretical MW: 18469.9
- GRAVY: -0.358025
⊟Function[edit | edit source]
- reaction: EC 2.7.7.3? ExPASyPantetheine-phosphate adenylyltransferase ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A pantetheine-phosphate adenylyltransferase (TIGR01510; EC 2.7.7.3; HMM-score: 183.4)and 9 morecytidyltransferase-like domain (TIGR00125; HMM-score: 61.7)Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate (nicotinamide) nucleotide adenylyltransferase (TIGR00482; EC 2.7.7.18; HMM-score: 47.6)nicotinamide-nucleotide adenylyltransferase (TIGR01526; EC 2.7.7.1; HMM-score: 22.3)Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glycerol-3-phosphate cytidylyltransferase (TIGR01518; EC 2.7.7.39; HMM-score: 19.3)Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinamide-nucleotide adenylyltransferase (TIGR01527; EC 2.7.7.1; HMM-score: 16.8)Protein fate Protein modification and repair [citrate (pro-3S)-lyase] ligase (TIGR00124; EC 6.2.1.22; HMM-score: 16.7)Energy metabolism Fermentation [citrate (pro-3S)-lyase] ligase (TIGR00124; EC 6.2.1.22; HMM-score: 16.7)Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides bifunctional protein RfaE, domain II (TIGR02199; EC 2.7.7.-; HMM-score: 15.2)Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A pantoate--beta-alanine ligase (TIGR00018; EC 6.3.2.1; HMM-score: 13.2)
- TheSEED :
- Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
- PFAM: HUP (CL0039) CTP_transf_like; Cytidylyltransferase-like (PF01467; HMM-score: 56.4)and 2 moreCitrate_ly_lig; Citrate lyase ligase C-terminal domain (PF08218; HMM-score: 27.5)Pantoate_ligase; Pantoate-beta-alanine ligase (PF02569; HMM-score: 13.5)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9717
- Cytoplasmic Membrane Score: 0.0018
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.0264
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001281
- TAT(Tat/SPI): 0.000197
- LIPO(Sec/SPII): 0.000271
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQGFLPLENRKRGLEKAVKHLGNVKVVSSHDKLVVDVAKRLGATCLVRGLRNASDLQYEASFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEKKD
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: SP_1967 < coaD < SP_1969 < asnA
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1766 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
Nucleic Acids Res: 2002, 30(14);3152-62
[PubMed:12136097] [WorldCat.org] [DOI] (I p) - ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)