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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_2214 [new locus tag: SP_RS11305 ]
- pan locus tag?: PNEUPAN003920000
- symbol: tsf
- pan gene symbol?: tsf
- synonym:
- product: translation elongation factor Ts
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_2214 [new locus tag: SP_RS11305 ]
- symbol: tsf
- product: translation elongation factor Ts
- replicon: chromosome
- strand: -
- coordinates: 2133145..2134185
- length: 1041
- essential: yes [1]
⊟Accession numbers[edit | edit source]
- Location: AE005672 (2133145..2134185) NCBI
- BioCyc:
- MicrobesOnline: 117621 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_2041 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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1021ATGGCAGAAATTACAGCTAAACTTGTAAAAGAGTTGCGTGAAAAATCTGGTGCCGGTGTT
ATGGACGCTAAAAAAGCGCTTGTAGAAACAGACGGTGACATCGAAAAAGCGATTGAATTG
CTTCGTGAAAAAGGTATGGCTAAGGCAGCTAAGAAAGCTGACCGTGTTGCTGCAGAAGGT
TTGACTGGTGTTTATGTTAACGGTAATGTTGCAGCAGTTATTGAAGTAAACGCTGAAACT
GACTTCGTTGCAAAAAACGCTCAATTCGTTGAATTGGTAAATACTACAGCTAAAGTCATT
GCTGAAGGAAAACCTGCTAACAACGAAGAAGCTCTTGCTTTGATAATGCCTTCAGGTGAA
ACTCTTGAAGCTGCATACGTATCTGCAACAGCAACTATCGGAGAGAAAATCTCATTCCGT
CGCTTTGCATTGATTGAAAAAACAGACGCACAACACTTTGGAGCATACCAACATAACGGT
GGACGTATCGGTGTTATTTCAGTTGTTGAAGGTGGAGACGAAGCACTTGCTAAACAATTG
TCAATGCACATCGCAGCGATGAAACCAACAGTTCTTTCTTACAAAGAATTGGATGAGCAA
TTCGTTAAAGATGAGTTGGCACAATTGAATCACGTTATCGACCAAGACAACGAAAGCCGT
GCAATGGTTAATAAACCAGCTCTTCCACACTTGAAGTATGGATCAAAAGCTCAATTAACT
GATGATGTTATTGCTCAAGCTGAAGCTGACATCAAAGCTGAATTGGCTGCAGAAGGCAAA
CCAGAAAAAATCTGGGACAAAATTATTCCAGGTAAAATGGATCGCTTCATGCTTGATAAC
ACTAAAGTTGACCAAGCTTACACACTTCTTGCACAAGTTTACATCATGGATGACAGCAAG
ACAGTTGAAGCATACCTTGAATCAGTTAACGCTTCGGTAGTTGAGTTTGCTCGCTTTGAA
GTTGGTGAAGGTATCGAGAAAGCTGCAAACGACTTCGAAGCTGAAGTTGCAGCTACAATG
GCAGCAGCCTTGAATAACTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_2214 [new locus tag: SP_RS11305 ]
- symbol: Tsf
- description: translation elongation factor Ts
- length: 346
- theoretical pI: 4.56342
- theoretical MW: 37361.2
- GRAVY: -0.158092
⊟Function[edit | edit source]
- TIGRFAM: Protein synthesis Translation factors translation elongation factor Ts (TIGR00116; HMM-score: 313.8)
- TheSEED :
- Translation elongation factor Ts
- PFAM: no clan defined EF_TS; Elongation factor TS (PF00889; HMM-score: 227.1)and 3 moreTPR (CL0020) ELMO_ARM; ELMO, armadillo-like helical domain (PF11841; HMM-score: 14.4)UBA (CL0214) UBA; UBA/TS-N domain (PF00627; HMM-score: 13.1)S11_L18p (CL0267) acVLRF1; Actinobacteria/chloroflexi VLRF1 release factor (PF18859; HMM-score: 11.4)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 10
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9914
- Cytoplasmic Membrane Score: 0
- Cell wall & surface Score: 0
- Extracellular Score: 0.0086
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.007192
- TAT(Tat/SPI): 0.001102
- LIPO(Sec/SPII): 0.000702
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MAEITAKLVKELREKSGAGVMDAKKALVETDGDIEKAIELLREKGMAKAAKKADRVAAEGLTGVYVNGNVAAVIEVNAETDFVAKNAQFVELVNTTAKVIAEGKPANNEEALALIMPSGETLEAAYVSATATIGEKISFRRFALIEKTDAQHFGAYQHNGGRIGVISVVEGGDEALAKQLSMHIAAMKPTVLSYKELDEQFVKDELAQLNHVIDQDNESRAMVNKPALPHLKYGSKAQLTDDVIAQAEADIKAELAAEGKPEKIWDKIIPGKMDRFMLDNTKVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKAANDFEAEVAATMAAALNN
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site: 2134257 [2]
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_2041 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Tim van Opijnen, Andrew Camilli
A fine scale phenotype-genotype virulence map of a bacterial pathogen.
Genome Res: 2012, 22(12);2541-51
[PubMed:22826510] [WorldCat.org] [DOI] (I p) - ↑ 2.0 2.1 2.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)