From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS06050 [old locus tag: SP_1234 ]
  • pan locus tag?: PNEUPAN002474000
  • symbol: SP_RS06050
  • pan gene symbol?: niaR
  • synonym:
  • product: transcription repressor NadR

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS06050 [old locus tag: SP_1234 ]
  • symbol: SP_RS06050
  • product: transcription repressor NadR
  • replicon: chromosome
  • strand: +
  • coordinates: 1166238..1166753
  • length: 516
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (1166238..1166753) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_1234
  • PneumoBrowse for strain D39V: SPV_1093 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGACAAAAGATCGCAAACAAGCCCTGCTCCAACTCTTGAAAGAAGCTCCTAAAGCCCTC
    AATGGCCAAAGATTAGCTGAGCACTTTCATGTCACTCGACAAGTTATTGTTCAAGATATT
    GCAATTTTAAGAGCTGATGGATCTCCAATTCTATCTACCAATCGTGGTTATATCTATAAA
    GATGCTAATGCAAATACTTATCATCACAAATTATTTAAGGTCAAGCATGAAGTTGAAGAA
    ATTGGACGAGAATTACTTGCTATCGTAGATAATGGTGGTCGCGTTCAAAATATCTTGATT
    GATCATCCTGTTTATGGAGAGATTGAAACCTTACTAAAACTGACCTGTCGCCGCGACGTG
    CAACATTTTCTAGAACAAGTTGAACGTTCTGACTTTAAGCCAATTTCTGAGTTAACAGAT
    GGTATTCATTATCACCTAGTTGAAGCCGAGACACAACAAGACCTCCACTATATCGAGGAG
    GCCTTGGATCAGCTAGGTTATTTAGTAAAAGACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    516

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS06050 [old locus tag: SP_1234 ]
  • symbol: SP_RS06050
  • description: transcription repressor NadR
  • length: 171
  • theoretical pI: 6.34468
  • theoretical MW: 19729.3
  • GRAVY: -0.432164

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions biotin operon repressor (TIGR00122; HMM-score: 19.1)
  • TheSEED: see SP_1234
  • PFAM:
    no clan defined 3H; 3H domain (PF02829; HMM-score: 110)
    and 6 more
    HTH (CL0123) HTH_11; HTH domain (PF08279; HMM-score: 55.4)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 16.4)
    MarR_2; MarR family (PF12802; HMM-score: 14.5)
    HTH_PafC; PafC helix-turn-helix domain (PF19187; HMM-score: 13.8)
    PuR_N; Bacterial purine repressor, N-terminal (PF09182; HMM-score: 12.8)
    no clan defined DUF4869; Domain of unknown function (DUF4869) (PF16163; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by NiaR*, TF important in NAD biosynthesis: see SP_1234

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9961
    • Cytoplasmic Membrane Score: 0.0025
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.001
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005511
    • TAT(Tat/SPI): 0.00112
    • LIPO(Sec/SPII): 0.000651
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTKDRKQALLQLLKEAPKALNGQRLAEHFHVTRQVIVQDIAILRADGSPILSTNRGYIYKDANANTYHHKLFKVKHEVEEIGRELLAIVDNGGRVQNILIDHPVYGEIETLLKLTCRRDVQHFLEQVERSDFKPISELTDGIHYHLVEAETQQDLHYIEEALDQLGYLVKD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: see SP_1234

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Oscar P Kuipers, Sulman Shafeeq
Niacin-mediated Gene Expression and Role of NiaR as a Transcriptional Repressor of niaX, nadC, and pnuC in Streptococcus pneumoniae.
Front Cell Infect Microbiol: 2017, 7;70
[PubMed:28337428] [WorldCat.org] [DOI] (I e)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SP_RS06050&oldid=1188"