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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS06595 [old locus tag: SP_1344 ]
  • pan locus tag?: PNEUPAN000141000
  • symbol: SP_RS06595
  • pan gene symbol?: lanL
  • synonym:
  • product: lanthionine synthetase LanC family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS06595 [old locus tag: SP_1344 ]
  • symbol: SP_RS06595
  • product: lanthionine synthetase LanC family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1267611..1270220
  • length: 2610
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (1267611..1270220) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_1344
  • PneumoBrowse for strain D39V: SPV_1179 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    ATGGATTATAATTTCAATTTGGAGCATCCTTTCTTTTTCACTAATAATGATTATAGTACA
    GATACTAGCATAAAGTACCAAGTAAGTCTGCCTTTTAATTGGCACGAAGTAATGAATAAT
    GATGAGTGGGTTTATCAATACCCTATTGGAAAATTTGTTGAAAGACAAGGGTGGAAAATA
    CACATTAGTTCAGAGTATAACAGTTCACATGAATTGTTACAAGATGTAGCAAAAATTTGC
    CATGAAATGCGAATTCCATTTAAACATCTTAGTACAGAAGACAAATTTATCATGCGAAAC
    GGGAAATTGGTTAGTCGAGGATTTTCTGGTAAATTTATTACATGTTATCCAAATCAAAAT
    GAATTAGAGTCGGTTTTGCAAAGGTTAGAAAGTGCCTTAAAGCAATATAATGGGCCATAT
    ATTTTAAGCGATAAACGTTGGGATGAAGCACCAATATATCTGAGGTATGGTGTGTTTAGG
    CCGTCAAGGGATGATGAAAAGAAGGTTGCTATTGATGAATTAATTGTTGGCGATGAAGTT
    GTTAAAGATGAACGTTTACCAGTATTTAAAATTCCAAAAGGTATAGTGCCCCCTGACTTT
    TTGAATAAATGGCTTGACAAGAAAGATAAAAAACAGGGAGACTTTCCCTTTATTATAGAT
    AATGCAATTAGATTTTCAAACAGTGGTGGGATATATAATGCTAGGCTAAAAGAAGATGGG
    AAAAAAATAATTTTAAAAGAGGCTAGACCGTATACAGGTCTAGGATTTGATGGTACTTAT
    TCTTCAGAGAAATTAGCTTCGGAGTGCAAAGCACTAAAAATTCTAAATGAATGGAGTGAG
    ACGCCTAAAATATACTGGCACGGTAAGATCTGGGAGCACACCTTCTTAGGAATTGAACAT
    ATGAAGGGCGTTCCACTAAATAGATGGGTTACCAATAATTTTCCTTTATATGAAGTTGTT
    GATAAGACCAAAGATTATCTATTGAGAGTTTCAAAGATAGTAGAAAAACTCATCGATTTA
    ACGAATAAGTTTCATTCTGAAAATGTATATCATCAAGATTTACATTTAGGAAATATCTTG
    GTTAAGGATGAAGATGAGATTAGTATAATAGACTGGGAACAGGCTGTCTTTTCAAATGAT
    GAAAAAGTTGTACATAAAGTTGCAGCCCCTGGTTTTAGAGCATGGCGAGAAACACTTCCC
    AGTGAGATAGATTGGTATGGTATTAGACAAATAGCTCATTATTTATACATGCCACTAGTA
    ACTACATCGGATTTGACATACAACTATGTAAGTCAAACCAGGATAGAAGGAAAAAAACTA
    TTTGAGTCTTTGGGTTATACAAGAGAACATATAGATTATGTAGAAAGTTTATTGTCATAT
    CTAGATTCTAAATGTCCACAGATTGAGAATATTTCCAGGAAAAAAGTTTTAAAACCCATG
    CATGAGATTAGAACTATCGAGAGTGAGCAAGATATACAAGATTTTATTATAAAATTATTG
    AGAGGGTTTACGCTAACTTATGGACAGTGGCGTAAAGAATTTCAATCAAGATTCTTCCCA
    GTTCATTATTATGGTCTGAATTTTAATCAAGGAATTGCGTTTTCAGATTTAGCTATCCTT
    TGGAGTTATCAACAACTAGCTAAGAAAGTAAAAAATTTCAAGTTTGATGACTATTATGAG
    ATTCGAACACAGGTTATTAATGAGGCAGTAAATAATTTTAAGAAATCGTCCCTTTCTGGT
    CTTTTTGATGGTAAAATTGGTACAATCTGGCTCATTTATGAATTTGGGGAGATAGATCGG
    GCAGTTGAACTTTTTACAACTCATTTTATAGAGATATTTGAGAATTCACAAAATAAAAAT
    TTATATAGTGGGCAGGCTGGAATTTTACTGGTTGGACTGTATTTTCTTAGTAAAGGGGGA
    ATTGATAATAAACTAGGAGAAGAAATACTAATTAGGCTTAGAGAATATACTTTAAATTAT
    ATAGAAAATCCAGAAACTTTTTGTAAAGTTGGCGCTAGTGATGTTCAGAGTAACGATCCT
    TATGAGAATTTTGGTGGATTACTATATGGTCACGCAGGGGTAGCTTGGCTCTTCGGTGAA
    GCTTATAAATTAACTGGTGAAAGTATCTATAAAAATGGTCTAGAATTGGCTGTAGATAAA
    GAATTAGTTGCTTATAAAGTAGATAGTAATAATTCATTGCAGTACAGCCAAGGTCATAGA
    TTACTACCATATCTAGCAACTGGAAGTGCTGGCCTGCTTTTACTTATTAATAGAAATAAA
    GAAATCTTGTCAAGCAAATACTTAAAATATTTAACTTCTTTAGAGAGGGCAACTGATGTA
    GTTTTTTGTGTATTACCAGGTTTATTTAACGGATTTTGTGGTCTTGAAGTTGCTAATAAT
    ATATATAGTGATATCGATGATAACTTTTCAGGACAAAAGAAATTAATTGAACAACTTTAT
    AGATATTTGTGTGTAATTGAAGAAGGATTTGTTATTGCGGGAGATAATGGTTTAAAGATA
    ACAACAGATATTGCTTCGGGATTTGCGGGTGTTGCAATTGGATTGGTATCAATAATGGAT
    AATAAATTGACGATTCTTCCTCAAATATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2610

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS06595 [old locus tag: SP_1344 ]
  • symbol: SP_RS06595
  • description: lanthionine synthetase LanC family protein
  • length: 869
  • theoretical pI: 6.11963
  • theoretical MW: 100446
  • GRAVY: -0.313809

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Toxin production and resistance type 2 lantibiotic biosynthesis protein LanM (TIGR03897; HMM-score: 30.5)
    and 3 more
    Unknown function General Kae1-associated kinase Bud32 (TIGR03724; EC 2.7.-.-; HMM-score: 24.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-polyprenylphenol 6-hydroxylase (TIGR01982; EC 1.14.13.-; HMM-score: 17.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine kinase (TIGR02721; EC 2.7.1.89; HMM-score: 12.9)
  • TheSEED: see SP_1344
  • PFAM:
    6_Hairpin (CL0059) LANC_like; Lanthionine synthetase C-like protein (PF05147; HMM-score: 33.9)
    PKinase (CL0016) Pkinase; Protein kinase domain (PF00069; HMM-score: 32)
    and 7 more
    ABC1; ABC1 atypical kinase-like domain (PF03109; HMM-score: 24.8)
    APH; Phosphotransferase enzyme family (PF01636; HMM-score: 24)
    Kdo; Lipopolysaccharide kinase (Kdo/WaaP) family (PF06293; HMM-score: 20.4)
    RIO1; RIO1 family (PF01163; HMM-score: 20.3)
    Choline_kinase; Choline/ethanolamine kinase (PF01633; HMM-score: 18.1)
    Haspin_kinase; Haspin like kinase domain (PF12330; HMM-score: 17.6)
    TCAD9; Ternary complex associated domain 9 (PF19974; HMM-score: 14.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.3585
    • Cytoplasmic Membrane Score: 0.4623
    • Cell wall & surface Score: 0.0035
    • Extracellular Score: 0.1757
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012394
    • TAT(Tat/SPI): 0.000177
    • LIPO(Sec/SPII): 0.001198
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDYNFNLEHPFFFTNNDYSTDTSIKYQVSLPFNWHEVMNNDEWVYQYPIGKFVERQGWKIHISSEYNSSHELLQDVAKICHEMRIPFKHLSTEDKFIMRNGKLVSRGFSGKFITCYPNQNELESVLQRLESALKQYNGPYILSDKRWDEAPIYLRYGVFRPSRDDEKKVAIDELIVGDEVVKDERLPVFKIPKGIVPPDFLNKWLDKKDKKQGDFPFIIDNAIRFSNSGGIYNARLKEDGKKIILKEARPYTGLGFDGTYSSEKLASECKALKILNEWSETPKIYWHGKIWEHTFLGIEHMKGVPLNRWVTNNFPLYEVVDKTKDYLLRVSKIVEKLIDLTNKFHSENVYHQDLHLGNILVKDEDEISIIDWEQAVFSNDEKVVHKVAAPGFRAWRETLPSEIDWYGIRQIAHYLYMPLVTTSDLTYNYVSQTRIEGKKLFESLGYTREHIDYVESLLSYLDSKCPQIENISRKKVLKPMHEIRTIESEQDIQDFIIKLLRGFTLTYGQWRKEFQSRFFPVHYYGLNFNQGIAFSDLAILWSYQQLAKKVKNFKFDDYYEIRTQVINEAVNNFKKSSLSGLFDGKIGTIWLIYEFGEIDRAVELFTTHFIEIFENSQNKNLYSGQAGILLVGLYFLSKGGIDNKLGEEILIRLREYTLNYIENPETFCKVGASDVQSNDPYENFGGLLYGHAGVAWLFGEAYKLTGESIYKNGLELAVDKELVAYKVDSNNSLQYSQGHRLLPYLATGSAGLLLLINRNKEILSSKYLKYLTSLERATDVVFCVLPGLFNGFCGLEVANNIYSDIDDNFSGQKKLIEQLYRYLCVIEEGFVIAGDNGLKITTDIASGFAGVAIGLVSIMDNKLTILPQI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: see SP_1344

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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