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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 23-APR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_RS10205 [old locus tag: SP_2016 ]
- pan locus tag?: PNEUPAN003648000
- symbol: nadC
- pan gene symbol?: nadC
- synonym:
- product: carboxylating nicotinate-nucleotide diphosphorylase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_RS10205 [old locus tag: SP_2016 ]
- symbol: nadC
- product: carboxylating nicotinate-nucleotide diphosphorylase
- replicon: chromosome
- strand: -
- coordinates: 1922125..1922997
- length: 873
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_003028 (1922125..1922997) NCBI
- BioCyc:
- MicrobesOnline: see SP_2016
- PneumoBrowse for strain D39V: SPV_1826 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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841ATGTCAATCATTTCAACTGATTTAACCCCTTTTCAAATAGATGATACATTGAAAGCAGCC
TTGCGAGAAGATGTTCATTCCGAAGATTACAGTACCAATGCCATTTTTGATCATCATGGC
CAAGCCAAGGTGTCGCTTTTTGCCAAGGAAGCTGGTGTTTTAGCGGGGCTAACCGTTTTT
CAAAGGGTTTTTACCCTATTTGATGCCGAGGTGACCTTCCAGAATCCTCATCAATTTAAG
GATGGGGATCGTTTGACTAGTGGCGATTTGGTTTTAGAAATCATAGGCTCGGTGAGAAGT
CTCTTAACATGTGAACGCGTTGCCTTGAATTTTTTACAACATTTATCAGGGATTGCTTCG
ATGACAGCTGCTTATGTAGAAGCCTTAGGCGATGATTGCATTAAGGTATTTGATACTCGA
AAAACTACTCCTAATTTACGTCTTTTTGAGAAATATGCCGTGAGAGTTGGCGGTGGCTAT
AATCATCGCTTTAATTTATCAGATGCTATCCTGCTAAAAGACAATCACATTGCGGCAGTA
GGTAGTGTTCAAAAGGCAATTGCTCAAGCGCGTGCCTATGCCCCTTTTGTGAAAATGGTC
GAGGTGGAAGTGGAAAGCCTTGCTGCTGCCGAAGAAGCTGCGGCGGCGGGTGCTGATATT
ATCATGTTGGATAATATGTCATTGGAACAGATTGAACAGGCCATTACCCTAATTGCAGGA
CGTTCTCGGATTGAATGTTCTGGAAATATTGATATGACCACTATTAGCCGTTTTCGTGGT
TTAGCGATTGATTACGTCTCCAGTGGTAGTTTAACCCATAGTGCTAAGAGTCTTGATTTT
TCCATGAAGGGGTTAACCTACCTTGATGTCTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_RS10205 [old locus tag: SP_2016 ]
- symbol: NadC
- description: carboxylating nicotinate-nucleotide diphosphorylase
- length: 290
- theoretical pI: 5.01683
- theoretical MW: 31602.8
- GRAVY: 0.107241
⊟Function[edit | edit source]
- reaction: EC 2.4.2.19? ExPASyNicotinate-nucleotide diphosphorylase (carboxylating) Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate-nucleotide diphosphorylase (carboxylating) (TIGR00078; EC 2.4.2.19; HMM-score: 366.5)and 1 moreUnknown function General modD protein (TIGR01334; HMM-score: 99)
- TheSEED: see SP_2016
- PFAM: TIM_barrel (CL0036) QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 201.7)and 1 moreHybrid (CL0105) QRPTase_N; Quinolinate phosphoribosyl transferase, N-terminal domain (PF02749; HMM-score: 93.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9973
- Cytoplasmic Membrane Score: 0.0003
- Cell wall & surface Score: 0
- Extracellular Score: 0.0023
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.00263
- TAT(Tat/SPI): 0.000175
- LIPO(Sec/SPII): 0.000364
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAILLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGADIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- see SP_2016
⊟Regulation[edit | edit source]
- regulator: NiaR* see SP_2016
⊟Transcription[edit | edit source]
- transcription start site: see SP_2016
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1826 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)