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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034183
  • locus tag: SPN034183_RS09805 [old locus tag: SPN034183_17780 ]
  • pan locus tag?: PNEUPAN003648000
  • symbol: nadC
  • pan gene symbol?: nadC
  • synonym:
  • product: carboxylating nicotinate-nucleotide diphosphorylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034183_RS09805 [old locus tag: SPN034183_17780 ]
  • symbol: nadC
  • product: carboxylating nicotinate-nucleotide diphosphorylase
  • replicon: chromosome
  • strand: -
  • coordinates: 1803549..1804421
  • length: 873
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021028 (1803549..1804421) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1826 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGTCAATCATTTCAACTGATTTAACCCCTTTTCAAATAGATGATACATTGAAAGCAGCC
    TTGCGAGAAGATGTTCATTCCGAAGATTACAGTACCAATGCCATTTTTGATCATCATGGC
    CAAGCCAAGGTGTTGCTTTTTGCCAAGGAAGCTGGTGTTTTAGCGGGGCTAACCGTTTTT
    CAAAGGGTTTTTACCCTATTTGATGCCGAGGTGACCTTCCAGAATCCTCATCAATTTAAG
    GATGGGGATCGTTTGACTAGTGGCGATTTGGTTTTAGAAATCATAGGCTCGGTGAGAAGT
    CTCTTAACATGTGAACGCGTTGCCTTGAATTTTTTACAACATTTATCAGGGATTGCTTCG
    ATGACAGCTGCTTATGTAGAAGCCTTAGGCGATGATTGCATTAAGGTATTTGATACTCGA
    AAAACTACTCCTAATTTACGTCTTTTTGAGAAATATGCCGTGAGAGTTGGCGGTGGCTAT
    AATCATCGCTTTAATTTATCAGATGCTATCATGCTAAAAGACAATCACATTGCGGCAGTA
    GGTAGTGTTCAAAAGGCAATTGCTCAAGCGCGTGCCTATGCCCCTTTTGTGAAAATGGTC
    GAGGTGGAAGTGGAAAGCCTTGCTGCTGCCGAAGAAGCTGCGGCGGCGGGTGCTGATATT
    ATCATGTTGGATAATATGTCATTGGAACAGATTGAACAGGCCATTACCCTAATTGCAGGA
    CGTTCTCGGATTGAATGTTCTGGAAATATTGATATGACCACTATTAGCCGTTTTCGTGGT
    TTAGCGATTGATTACGTCTCCAGTGGTAGTTTAACCCATAGTGCTAAGAGTCTTGATTTT
    TCCATGAAGGGGTTAACCTACCTTGATGTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    873

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034183_RS09805 [old locus tag: SPN034183_17780 ]
  • symbol: NadC
  • description: carboxylating nicotinate-nucleotide diphosphorylase
  • length: 290
  • theoretical pI: 5.01683
  • theoretical MW: 31646.9
  • GRAVY: 0.116552

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.2.19?  ExPASy
    Nicotinate-nucleotide diphosphorylase (carboxylating) Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate-nucleotide diphosphorylase (carboxylating) (TIGR00078; EC 2.4.2.19; HMM-score: 366.7)
    and 2 more
    Unknown function General modD protein (TIGR01334; HMM-score: 96.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 11.4)
  • TheSEED: see SPN034183_17780
  • PFAM:
    TIM_barrel (CL0036) QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 203.3)
    and 1 more
    Hybrid (CL0105) QRPTase_N; Quinolinate phosphoribosyl transferase, N-terminal domain (PF02749; HMM-score: 91.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9976
    • Cytoplasmic Membrane Score: 0.0003
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.002
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002201
    • TAT(Tat/SPI): 0.000148
    • LIPO(Sec/SPII): 0.000334
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000022745 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVLLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGADIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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