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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae A026
- locus tag: T308_08405 [new locus tag: T308_RS08590 ]
- pan locus tag?: PNEUPAN003348000
- symbol: T308_08405
- pan gene symbol?: galR
- synonym:
- product: LacI family transcriptional regulator
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: T308_08405 [new locus tag: T308_RS08590 ]
- symbol: T308_08405
- product: LacI family transcriptional regulator
- replicon: chromosome
- strand: +
- coordinates: 1643262..1644269
- length: 1008
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: CP006844 (1643262..1644269) NCBI
- BioCyc: see T308_RS08590
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1635 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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961ATGGCTACCTTAAAAGACATTGCACAGCTAGCCTCTGTCTCTATCGCGACCGTATCCCGT
GTCCTCAACCGCGACCAGAGCCTATCTGTTACAGAAGAAACCAGACACCGTATTTTAACC
GTTGCTGAAGAGCTGGGCTACACCAAGCACCTCAAGACAGGCGAGTCCCATAAACCCAAG
CAAAAGATTGCCATTATTCAATGGGTCAGCGAACAAGGGGAGCTAGACGACCTCTACTAC
TACCAGATTCGCCTAGGAATAGAAAAAAGAGCCCAAGAGTTGGACTACGATATCTTGCGC
TATTTTAATGACCACCCTTTTACCCTAAGCGAGGAAGTGATTGGGATTCTCTGCATCGGA
AAATTTAGCCGAGCTCAGATTTCTGCCTTTGAAGAATACCAAAAGCCTCTTGTATTTCTA
GACAGCGATACACTTTCCCTGGGACATACCTGTATTATCACGGATTTTTACACTGCTATG
AAACAGGTTGTCGATTATTTCCTCAGTCAAGGGATGGACCGCATCGGGATTCTAACAGGG
CTTGAGGAAACAACAGACCAAGAAGAAATCATTCAGGACAAGCGTCTAGAAAACTTCAAA
AACTACAGTCAAGCGAGGGGAATCTATCATGATGAACTGGTCTTTCAAGGAAGATTTACT
GCCCAGTCTGGCTATGACTTAATGAAGGAGGCCATTCAGAGCTTGGGAGACCAACTTCCG
CCAGCATTTTTCGCAGCCAGCGATAGTTTAGCTATCGGTGCCCTCCGTGCCCTCCAAGAA
GCTGGAATCAGCCTGCCAGATCGCGTCAGCCTCATTTCATTCAACGACACCAGTCTGACC
AAACAGGTCTATCCTCCCCTCTCTAGTATTACAGTTTATACTGAAGAAATGGGGCGAGCA
GGTATGGATATTCTTAACAAGGAAGTCCTCCACGGTCGCAAAATTCCTAGCCTGACCATG
CTGGGAACCAGACTGACATTAAGAGAAAGTACCCTAAATCAAGAATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: T308_08405 [new locus tag: T308_RS08590 ]
- symbol: T308_08405
- description: LacI family transcriptional regulator
- length: 335
- theoretical pI: 4.84544
- theoretical MW: 37878.8
- GRAVY: -0.23403
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 117.8)and 2 moreRegulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 78.1)Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 71.1)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: Periplas_BP (CL0144) Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 104.4)and 4 moreHTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 60.2)Periplas_BP (CL0144) Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 35)Peripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 23.7)HTH (CL0123) HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 14.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
- genes regulated by GalR, TF important in Galactose utilization: in TIGR4
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.027804
- TAT(Tat/SPI): 0.004294
- LIPO(Sec/SPII): 0.004172
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: AGZ48348 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MATLKDIAQLASVSIATVSRVLNRDQSLSVTEETRHRILTVAEELGYTKHLKTGESHKPKQKIAIIQWVSEQGELDDLYYYQIRLGIEKRAQELDYDILRYFNDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPLVFLDSDTLSLGHTCIITDFYTAMKQVVDYFLSQGMDRIGILTGLEETTDQEEIIQDKRLENFKNYSQARGIYHDELVFQGRFTAQSGYDLMKEAIQSLGDQLPPAFFAASDSLAIGALRALQEAGISLPDRVSLISFNDTSLTKQVYPPLSSITVYTEEMGRAGMDILNKEVLHGRKIPSLTMLGTRLTLRESTLNQE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- data available for TIGR4
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1635 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Muhammad Afzal, Sulman Shafeeq, Irfan Manzoor, Oscar P Kuipers
GalR Acts as a Transcriptional Activator of galKT in the Presence of Galactose in Streptococcus pneumoniae.
J Mol Microbiol Biotechnol: 2015, 25(6);363-71
[PubMed:26544195] [WorldCat.org] [DOI] (I p)