From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A026
  • locus tag: T308_RS05640 [old locus tag: T308_05565 ]
  • pan locus tag?: PNEUPAN002393000
  • symbol: T308_RS05640
  • pan gene symbol?: pyrC
  • synonym:
  • product: dihydroorotase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: T308_RS05640 [old locus tag: T308_05565 ]
  • symbol: T308_RS05640
  • product: dihydroorotase
  • replicon: chromosome
  • strand: -
  • coordinates: 1097299..1098567
  • length: 1269
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_022655 (1097299..1098567) NCBI
  • BioCyc: T308_RS05640 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1030 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGCTACTAATCAAAAATGGTCATGTAATGGATCCCAAGTCTGGTTTGGATCAAGTTTGT
    GATGTCTTAGTTCAAGATGGGAAAATTATCAAAATTGCGCCTGAGATCACGGAAGAAGGA
    GCAGAAACGATTGATGCTACTGGTCTTGTGGTTGCTCCTGGTTTGGTCGATATTCATGTG
    CATTTCCGTGAACCTGGTCAAACACATAAAGAAGACATTCATACTGGTGCCCTAGCAGCC
    GCTGCAGGTGGTTTTACTACTGTCGTCATGATGGCTAATACCAGTCCAACCATTTCAGAC
    GTGGAGACTTTGCAAGCAGTTCTCCAGTCAGCTGCCAAAGAGAAGATTAATGTCAAGACA
    GTTGCGACCATTACTAAAAACTTTAATGGTAAAAACTTGACTGACTTTAAGGCGCTCTTA
    GAAGCTGGTGCGGTTGGTTTCTCTGATGACGGTATTCCGCTTGAGAGCAGTAAGATTGTC
    AAGGAAGCCATGGAGGAAGCCAAAAAACTCAATACCTTTATCAGCCTTCATGAGGAAGAT
    CCAGGTTTGAACGGTGTTCTTGGCTTTAATGAAAATATTGCTAGAGAACATTTCCATATC
    TGCGGTGCTACTGGGGTGGCTGAGTACGCTATGATGGCGCGTGATGTCATGATTGCCTAT
    GCAACTAAAGCCCATGTTCACATCCAGCATTTGTCTAAGGAAGAAAGTGTTAAAGTAGTG
    GAGTTTGCTCAGGGGTTAGGTGCAGAAGTCACAGCAGAAGTAGCGCCACAGCATTTCTCT
    AAGACAGAAGCACTTCTTTTAACACAAGGTAGCAATGCTAAGATGAATCCACCGCTTCGT
    TTGGAATCAGACCGTCGTGCCGTTATCGAAGGTCTCAAATCAGGTGTCATCACAGTTATT
    GCGACTGACCACGCGCCTCATCATGTAGATGAAAAAAATGTTGAGGATATTACCAAAGCG
    CCATCTGGTATGACTGGCTTAGAAACATCTCTGTCTCTCGGCTTGACCTATTTAGTAGAA
    GCTGGTGAGTTGAGCTTGATGGAATTACTTGAAAAAATGACATACAACCCAGCCAAGCTT
    TACAACTTTGAAGCAGGTTACTTGGCTGAGAATGGTCCAGCAGATATCACTATTTTTGAT
    GCCAAGGCTGACCGCCTTGTGGACTCCCATTTTGCTTCCAAAGCAGCTAATTCACCATTC
    ATCGGTGAAACCTTAAAAGGGCAGGTTAAATATACCATCTGTAAGGGACAAATCGTCTAT
    CAAGCTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1269

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: T308_RS05640 [old locus tag: T308_05565 ]
  • symbol: T308_RS05640
  • description: dihydroorotase
  • length: 422
  • theoretical pI: 5.09414
  • theoretical MW: 45281.4
  • GRAVY: -0.0509479

⊟Function[edit | edit source]

  • reaction:
    EC 3.5.2.3?  ExPASy
    Dihydroorotase (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotase, multifunctional complex type (TIGR00857; EC 3.5.2.3; HMM-score: 358.8)
    and 13 more
    allantoinase (TIGR03178; EC 3.5.2.5; HMM-score: 220)
    dihydropyrimidinase (TIGR02033; EC 3.5.2.2; HMM-score: 173)
    formylmethanofuran dehydrogenase subunit A (TIGR03121; EC 1.2.99.5; HMM-score: 50.2)
    Hypothetical proteins Conserved putative amidohydrolase, EF_0837/AHA_3915 family (TIGR03583; HMM-score: 45.5)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides beta-aspartyl peptidase (TIGR01975; EC 3.4.19.5; HMM-score: 37.7)
    Metabolism Central intermediary metabolism Amino sugars N-acetylglucosamine-6-phosphate deacetylase (TIGR00221; EC 3.5.1.25; HMM-score: 30.1)
    Metabolism Energy metabolism Other phosphonate metabolism protein PhnM (TIGR02318; HMM-score: 29.4)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotase, homodimeric type (TIGR00856; EC 3.5.2.3; HMM-score: 29.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine deaminase (TIGR01178; EC 3.5.4.2; HMM-score: 27.1)
    Metabolism Central intermediary metabolism Nitrogen metabolism urease, alpha subunit (TIGR01792; EC 3.5.1.5; HMM-score: 24.8)
    Metabolism Energy metabolism Amino acids and amines imidazolonepropionase (TIGR01224; EC 3.5.2.7; HMM-score: 23.4)
    putative selenium metabolism protein SsnA (TIGR03314; HMM-score: 19.4)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Other guanine deaminase (TIGR02967; EC 3.5.4.3; HMM-score: 15.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Amidohydrolase (CL0034) Amidohydro_1; Amidohydrolase family (PF01979; HMM-score: 114.6)
    and 4 more
    Amidohydro_3; Amidohydrolase family (PF07969; HMM-score: 62.2)
    DHOase; Dihydro-orotase-like (PF12890; HMM-score: 29.3)
    DUF6282; Family of unknown function (DUF6282) (PF19799; HMM-score: 18.3)
    TatD_DNase; TatD related DNase (PF01026; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9958
    • Cytoplasmic Membrane Score: 0.0005
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0032
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002973
    • TAT(Tat/SPI): 0.000214
    • LIPO(Sec/SPII): 0.000573
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000924465 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLLIKNGHVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIVKEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVVEFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKLYNFEAGYLAENGPADITIFDAKADRLVDSHFASKAANSPFIGETLKGQVKYTICKGQIVYQA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=T308_RS05640&oldid=32657"