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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_1281 [new locus tag: SPH_RS06200 ]
  • pan locus tag?: PNEUPAN002393000
  • symbol: SPH_1281
  • pan gene symbol?: pyrC
  • synonym:
  • product: dihydroorotase (DHOase)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_1281 [new locus tag: SPH_RS06200 ]
  • symbol: SPH_1281
  • product: dihydroorotase (DHOase)
  • replicon: chromosome
  • strand: -
  • coordinates: 1189141..1190409
  • length: 1269
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGCTACTAATCAAAAATGGTCGTGTAATGGATCCTAAGTCTGGTTTGGATCAGGTATGT
    GATGTTTTGGTCCGAGATGGGAAAATTGTCAAAATTGCACCTGAGATCACGGAAGAAGGA
    GCAGAACTGATTGACGCTACTGGTCTTGTGGTTGCGCCTGGACTGGTTGATATCCATGTT
    CATTTCCGTGAACCTGGTCAAACCCATAAAGAAGACATTCATACTGGTGCCCTAGCAGCC
    GCTGCAGGCGGTTTTACAACTGTTGTCATGATGGCTAATACTAGTCCAACCATTTCAGAT
    GTAGAAACCCTGCAAGAAGTTCTCCAGTCAGCTGCCAAAGAGAAGATTAATGTTAAGACG
    GTTGCGACCATTACTAAGAATTTTAATGGGCAAGATTTGACTGACTTTAAAGCACTCTTA
    GAAGCTGGAGCTGTTGGTTTTTCTGATGATGGTATTCCGCTTGAAAGCAGTAAAGTGGTC
    AAGGAAGCCATGGAGGAAGCCAAAAAGCTTAATACCTTTATTAGTCTTCATGAGGAAGAT
    CCAGGTTTGAATGGGATTCTTGGTTTTAACGAAAATATTGCTAAAGAACATTTCCATATC
    TGCGGTGCGACTGGGGTAGCTGAGTACGCTATGATGGCGCGTGATGTCATGATTGCCTAT
    GCAACCAAAGCCCATGTTCATATTCAGCATTTGTCTAAGGAAGAAAGTGTTAAAGTAGTG
    GAGTTTGCTCAAGGATTGGGTGCGCAAGTAACAGCAGAAGTAGCGCCACAACATTTCTCT
    AAGACAGAAGCACTTCTTTTGACTCAAGGTAGCAATGCTAAGATGAATCCTCCGCTTCGT
    TTGGAATCAGACCGTCGTGCTGTTATCGAAGGTCTTAAATCAGGCGTCATTACAGTTATC
    GCGACTGACCATGCGCCTCACCATGCGGATGAAAAAAATGTCGAAGATATTACCAAAGCG
    CCATCTGGTATGACTGGCTTAGAAACATCTCTATCTCTCGGTTTGACCTATTTGGTAGAA
    GCTGGGGAGTTGAACTTGATGGAATTACTTGAAAAAATGTCATACAACCCATCCAAGCTT
    TACAACTTTGAAGCAGGTTACTTGGCTGAGAATGGTCCAGCGGACATCACTATTTTTGAT
    GCTAAGGCTGACCGCCTTGTGGACTCCCAATTTGCTTCCAAAGCAGCTAATTCGCCATTC
    ATCGGTGAAACCTTAAAAGGGCAGGTTAAATACACCATCTGTAAGGGACAAATCGTCTAT
    CAAGCTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1269

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_1281 [new locus tag: SPH_RS06200 ]
  • symbol: SPH_1281
  • description: dihydroorotase (DHOase)
  • length: 422
  • theoretical pI: 4.94373
  • theoretical MW: 45348.4
  • GRAVY: -0.0758294

⊟Function[edit | edit source]

  • reaction:
    EC 3.5.2.3?  ExPASy
    Dihydroorotase (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotase, multifunctional complex type (TIGR00857; EC 3.5.2.3; HMM-score: 359.8)
    and 13 more
    allantoinase (TIGR03178; EC 3.5.2.5; HMM-score: 221.9)
    dihydropyrimidinase (TIGR02033; EC 3.5.2.2; HMM-score: 173.5)
    formylmethanofuran dehydrogenase subunit A (TIGR03121; EC 1.2.99.5; HMM-score: 49.4)
    Hypothetical proteins Conserved putative amidohydrolase, EF_0837/AHA_3915 family (TIGR03583; HMM-score: 39.7)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotase, homodimeric type (TIGR00856; EC 3.5.2.3; HMM-score: 30.6)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides beta-aspartyl peptidase (TIGR01975; EC 3.4.19.5; HMM-score: 28.3)
    Metabolism Central intermediary metabolism Nitrogen metabolism urease, alpha subunit (TIGR01792; EC 3.5.1.5; HMM-score: 26.6)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine deaminase (TIGR01178; EC 3.5.4.2; HMM-score: 26.2)
    Metabolism Central intermediary metabolism Amino sugars N-acetylglucosamine-6-phosphate deacetylase (TIGR00221; EC 3.5.1.25; HMM-score: 25.9)
    Metabolism Energy metabolism Other phosphonate metabolism protein PhnM (TIGR02318; HMM-score: 25.1)
    Metabolism Energy metabolism Amino acids and amines imidazolonepropionase (TIGR01224; EC 3.5.2.7; HMM-score: 23.1)
    putative selenium metabolism protein SsnA (TIGR03314; HMM-score: 21.7)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Other guanine deaminase (TIGR02967; EC 3.5.4.3; HMM-score: 14.2)
  • TheSEED  :
    • Dihydroorotase (EC 3.5.2.3)
    Nucleosides and Nucleotides Pyrimidines De Novo Pyrimidine Synthesis  Dihydroorotase (EC 3.5.2.3)
  • PFAM:
    Amidohydrolase (CL0034) Amidohydro_1; Amidohydrolase family (PF01979; HMM-score: 110.2)
    and 4 more
    Amidohydro_3; Amidohydrolase family (PF07969; HMM-score: 54.1)
    DHOase; Dihydro-orotase-like (PF12890; HMM-score: 28.8)
    DUF6282; Family of unknown function (DUF6282) (PF19799; HMM-score: 19.1)
    TatD_DNase; TatD related DNase (PF01026; HMM-score: 14.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.994
    • Cytoplasmic Membrane Score: 0.0008
    • Cell wall & surface Score: 0.0008
    • Extracellular Score: 0.0044
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00192
    • TAT(Tat/SPI): 0.000142
    • LIPO(Sec/SPII): 0.00038
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLLIKNGRVMDPKSGLDQVCDVLVRDGKIVKIAPEITEEGAELIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSPTISDVETLQEVLQSAAKEKINVKTVATITKNFNGQDLTDFKALLEAGAVGFSDDGIPLESSKVVKEAMEEAKKLNTFISLHEEDPGLNGILGFNENIAKEHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVVEFAQGLGAQVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHADEKNVEDITKAPSGMTGLETSLSLGLTYLVEAGELNLMELLEKMSYNPSKLYNFEAGYLAENGPADITIFDAKADRLVDSQFASKAANSPFIGETLKGQVKYTICKGQIVYQA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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