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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_1284 [new locus tag: SPH_RS06215 ]
  • pan locus tag?: PNEUPAN002396000
  • symbol: SPH_1284
  • pan gene symbol?: pynA
  • synonym:
  • product: HAD superfamily (subfamily IA) hydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_1284 [new locus tag: SPH_RS06215 ]
  • symbol: SPH_1284
  • product: HAD superfamily (subfamily IA) hydrolase
  • replicon: chromosome
  • strand: -
  • coordinates: 1191611..1192303
  • length: 693
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    TTGTCCTACAAATTTCTACTCTTCGACCTTGACCACACTCTTCTTGATTTTGATGCTGCT
    GAGGATGTGGCTTTGACGCAACTTCTAAAAGAAGAAGGGGTTGCAGATATTCAGGCTTAT
    AAAGACTATTACGTTCCTATGAACAAGGCTCTCTGGAAGGACTTGGAGCAAAAGAAAATC
    AGTAAACAAGAGCTGGTTAACACGCGCTTCTCTCGTTTATTTGCTCATTTTGGACAGGAA
    AAAGATGGTAGTTTTCTAGCCCAGTGTTACCAATTTTACCTCGCTCAACAGGGACAAACT
    TTTTCAGGCGCTCATGAACTCTTAGACAACCTCATCGAGCGAGATTATGAGCTATATGCT
    GCGACAAATGGCATTACTGCCATTCAGACAGGGCGTTTGGCTCAATCTGGTTTAGCACCT
    TATTTCAATCAAGTCTTTATCTCTGAACAGTTGCAAACACAAAAACCTGATGCTCTCTTT
    TATGAAAAAATTGGTCAACAGATTGCAGGTTTTAGCAAAGAAAAGACGCTGATGATTGGA
    GATTCCCTAACCGCCGACATTCAAGGTGGCAATAATGCGGGGATAGATACTATCTGGTAC
    AACCCTCATCACCTCGAAAATCACACACAAGCCCAGCCGACTTATGAAGTCCATTCTTAC
    CAAGACTTGCTGGATTATTTAGATAAACTGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    693

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_1284 [new locus tag: SPH_RS06215 ]
  • symbol: SPH_1284
  • description: HAD superfamily (subfamily IA) hydrolase
  • length: 230
  • theoretical pI: 4.54859
  • theoretical MW: 26314.3
  • GRAVY: -0.418261

⊟Function[edit | edit source]

  • TIGRFAM:
    noncanonical pyrimidine nucleotidase, YjjG family (TIGR02254; EC 3.1.3.5; HMM-score: 206.7)
    and 19 more
    HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 95.5)
    HAD hydrolase, REG-2-like, family IA (TIGR02252; HMM-score: 50.5)
    haloacid dehalogenase, type II (TIGR01428; EC 3.8.1.2; HMM-score: 45.8)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 1 (TIGR01549; HMM-score: 42.5)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIA (TIGR01460; HMM-score: 39.1)
    Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 37.1)
    AHBA synthesis associated protein (TIGR01454; HMM-score: 35.4)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 35.4)
    HAD hydrolase, TIGR01459 family (TIGR01459; HMM-score: 33.5)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 32.2)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01457 family (TIGR01457; HMM-score: 28.5)
    HAD phosphatase, family IIIA (TIGR01668; EC 3.1.3.-; HMM-score: 27)
    pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 24.7)
    phosphoglycolate/pyridoxal phosphate phosphatase family (TIGR01452; EC 3.1.3.18; HMM-score: 18.5)
    beta-phosphoglucomutase family hydrolase (TIGR02009; HMM-score: 18)
    histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 16.9)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01458 family (TIGR01458; HMM-score: 16.1)
    epoxide hydrolase N-terminal domain-like phosphatase (TIGR02247; HMM-score: 14.2)
    HAD hydrolase, family IIID (TIGR02245; HMM-score: 14.1)
  • TheSEED  :
    • 2-haloalkanoic acid dehalogenase (EC 3.8.1.2)
  • PFAM:
    HAD (CL0137) HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 87.7)
    and 3 more
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 44.2)
    Hydrolase_like; HAD-hyrolase-like (PF13242; HMM-score: 39.7)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 21.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9995
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0003
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003188
    • TAT(Tat/SPI): 0.000135
    • LIPO(Sec/SPII): 0.000382
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSYKFLLFDLDHTLLDFDAAEDVALTQLLKEEGVADIQAYKDYYVPMNKALWKDLEQKKISKQELVNTRFSRLFAHFGQEKDGSFLAQCYQFYLAQQGQTFSGAHELLDNLIERDYELYAATNGITAIQTGRLAQSGLAPYFNQVFISEQLQTQKPDALFYEKIGQQIAGFSKEKTLMIGDSLTADIQGGNNAGIDTIWYNPHHLENHTQAQPTYEVHSYQDLLDYLDKL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Aleš Ulrych, Denisa Petráčková, Jana Goldová, Karolína Buriánková, Linda Doubravová, Pavel Branny
PynA is a pyrimidine 5'-nucleotidase that functions as an antimutator protein in Streptococcus pneumoniae.
FEBS J: 2020, 287(2);267-283
[PubMed:31437335] [WorldCat.org] [DOI] (I p)

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