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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_RS00510 [old locus tag: SPNA45_00091 ]
  • pan locus tag?: PNEUPAN003702000
  • symbol: SPNA45_RS00510
  • pan gene symbol?: —
  • synonym:
  • product: helix-turn-helix transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_RS00510 [old locus tag: SPNA45_00091 ]
  • symbol: SPNA45_RS00510
  • product: helix-turn-helix transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 90645..90851
  • length: 207
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018594 (90645..90851) NCBI
  • BioCyc: SPNA45_RS00510 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1947 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    ATGCAACTAAAAAATCGTCTAAAAGAGCTTCGAGCTCGCGATGGTCTCAATCAAACCGAC
    CTAGCCAAACTGGCAGGGGTTTCCAGACAGACCATTAGCCTACTAGAACGGGATGAGTAC
    ACCCCATCCATTATCATTGCCCTGAAAATATCTCAAATTTTCAACGAAACAGTCGAATCG
    GTATTTCGTTTGGAGGAGGACGAGTGA
    60
    120
    180
    207

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_RS00510 [old locus tag: SPNA45_00091 ]
  • symbol: SPNA45_RS00510
  • description: helix-turn-helix transcriptional regulator
  • length: 68
  • theoretical pI: 4.75628
  • theoretical MW: 7847.91
  • GRAVY: -0.401471

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Signal transduction Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 41.3)
    and 6 more
    putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 22.7)
    Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.9)
    Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.9)
    Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.9)
    Signal transduction Regulatory functions DNA interactions DNA-binding protein, Tfx family (TIGR00721; HMM-score: 17.4)
    Unknown function General mobile mystery protein A (TIGR02612; HMM-score: 16.1)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞PFAM:
    HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 53.1)
    and 19 more
    HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 36.9)
    HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 35)
    HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 26.2)
    LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 20.1)
    MarR_2; MarR family (PF12802; HMM-score: 18.4)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 17.4)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 16.4)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 15.9)
    HTH_25; Helix-turn-helix domain (PF13413; HMM-score: 15.4)
    Phage_CI_repr; Bacteriophage CI repressor helix-turn-helix domain (PF07022; HMM-score: 15)
    MarR; MarR family (PF01047; HMM-score: 14.9)
    Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 14.9)
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 14.9)
    HTH_11; HTH domain (PF08279; HMM-score: 14.5)
    no clan defined DUF211; Uncharacterized ArCR, COG1888 (PF02680; HMM-score: 14.1)
    HTH (CL0123) HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 13.9)
    HTH_37; Helix-turn-helix domain (PF13744; HMM-score: 13.8)
    HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 13.6)
    no clan defined TnsD; Tn7-like transposition protein D (PF15978; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001278
    • TAT(Tat/SPI): 0.000304
    • LIPO(Sec/SPII): 0.000308
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001176227 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQLKNRLKELRARDGLNQTDLAKLAGVSRQTISLLERDEYTPSIIIALKISQIFNETVESVFRLEEDE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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