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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Xen35
  • locus tag: CXP32_RS08550 [old locus tag: CXP32_08550 ]
  • pan locus tag?: PNEUPAN003117000
  • symbol: nrdR
  • pan gene symbol?: nrdR
  • synonym:
  • product: transcriptional regulator NrdR

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: CXP32_RS08550 [old locus tag: CXP32_08550 ]
  • symbol: nrdR
  • product: transcriptional regulator NrdR
  • replicon: chromosome
  • strand: -
  • coordinates: 1616855..1617328
  • length: 474
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP025256 (1616855..1617328) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1523 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGCGTTGTCCAAAATGTGGGGCTACCAAGTCAAGTGTTATCGATAGTCGCCAAGCAGAA
    GAAGGGAACACCATTCGTAGAAGACGTGAGTGCGACGAATGCCAACACCGTTTTACAACC
    TACGAACGAGTAGAAGAAAGAACCTTAGTGGTTGTTAAAAAAGATGGCACACGGGAACAA
    TTCTCCAGAGATAAAATCTTTAATGGGATTATCCGCTCAGCCCAGAAACGTCCTGTGTCA
    AGTGATGAAATCAACATGGTAGTCAATCGTATCGAACAGAAACTCCGTGGTCGAAATGAA
    AATGAAATTCAAAGTGAGGACATTGGTTCACTCGTCATGGAGGAGTTGGCTGAATTGGAC
    GAGATTACCTATGTACGTTTTGCTAGTGTCTATCGTAGTTTTAAGGATGTCAGTGAGTTA
    GAGAGCTTGCTCCAACAAATCACCCAGTCCTCTAAAAAGAAAAAGGAAAGATAA
    60
    120
    180
    240
    300
    360
    420
    474

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: CXP32_RS08550 [old locus tag: CXP32_08550 ]
  • symbol: NrdR
  • description: transcriptional regulator NrdR
  • length: 157
  • theoretical pI: 8.63375
  • theoretical MW: 18379.6
  • GRAVY: -0.917834

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Signal transduction Regulatory functions DNA interactions transcriptional regulator NrdR (TIGR00244; HMM-score: 190.3)
    and 4 more
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions restriction alleviation protein, Lar family (TIGR03655; HMM-score: 16.3)
    Genetic information processing DNA metabolism Restriction/modification restriction alleviation protein, Lar family (TIGR03655; HMM-score: 16.3)
    Signal transduction Regulatory functions DNA interactions putative regulatory protein, FmdB family (TIGR02605; HMM-score: 15.3)
    Cys-rich peptide, TIGR04165 family (TIGR04165; HMM-score: 13.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞PFAM:
    no clan defined ATP-cone; ATP cone domain (PF03477; HMM-score: 73.6)
    and 9 more
    Zn_Beta_Ribbon (CL0167) TFIIS_C; Transcription factor S-II (TFIIS) (PF01096; HMM-score: 20.8)
    Zn_Tnp_IS1595; Transposase zinc-ribbon domain (PF12760; HMM-score: 19.2)
    POTRA (CL0191) POTRA_2; POTRA domain, ShlB-type (PF08479; HMM-score: 13.9)
    Zn_Beta_Ribbon (CL0167) Zn-ribbon_8; Zinc ribbon domain (PF09723; HMM-score: 13.7)
    zf-ribbon_3; zinc-ribbon domain (PF13248; HMM-score: 12.9)
    TF_Zn_Ribbon; TFIIB zinc-binding (PF08271; HMM-score: 11.9)
    Ogr_Delta; Ogr/Delta-like zinc finger (PF04606; HMM-score: 9.3)
    zinc_ribbon_4; zinc-ribbon domain (PF13717; HMM-score: 8.8)
    UPF0547; Uncharacterised protein family UPF0547 (PF10571; HMM-score: 8.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by NrdR*, TF important in Deoxyribonucleotide biosynthesis: in TIGR4

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.021569
    • TAT(Tat/SPI): 0.001095
    • LIPO(Sec/SPII): 0.006615
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001203672 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERVEERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENEIQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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