⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 05-OCT-2017

⊟Summary

• organism: Streptococcus pneumoniae MDRSPN001
locus tag: MDRSPN_01851 [new locus tag: MDRSPN_RS09735 ]
pan locus tag^?: PNEUPAN003812000
symbol: cglA
pan gene symbol^?: comGA
• synonym:
• product: competence protein CglA

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MDRSPN_01851 [new locus tag: MDRSPN_RS09735 ]
• symbol: cglA
• product: competence protein CglA
• replicon: chromosome
• strand: -
• coordinates: 1833391..1834332
• length: 942
• essential: unknown

⊟Accession numbers

• Location: AP018391 (1833391..1834332) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1863 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGAT
  ATCTATTTTGTCCCTAAGTTAGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGC
  TGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCGTTATCAGTCACTTTAAGTTT
  GTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
  TATGACCAGAAGATAGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAG
  AGTTTGGTTATCCGTTTGTTGCACGATGAGGAGCAGGACCTGCATTTTTGGTTTCAGGAT
  ATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGGCTCTATCTTTTTGCTGGTCCGGTT
  GGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
  GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTG
  AACGAAGCAATCGGCCTAACCTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCA
  GATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGGCGCGTGCAGTGGTCAGAGCT
  AGTTTGACAGGTGCGACAGTCTTTTCAACCATTCATGCTAAGAGTATCCGAGGTGTTTAT
  GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTTTGCAAGGAGTC
  TGCTACCAGAGATTAATCGGGGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAA
  GAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGCTTCTTAAAGATGGACATATC
  ACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  942
  

⊟Protein

⊟General

• locus tag: MDRSPN_01851 [new locus tag: MDRSPN_RS09735 ]
• symbol: CglA
• description: competence protein CglA
• length: 313
• theoretical pI: 6.01371
• theoretical MW: 35573.2
• GRAVY: -0.323962

⊟Function

• ⊞⊞TIGRFAM:
  Cellular processes Cellular processes Pathogenesis type II secretion system protein E (TIGR02533; HMM-score: 144.4)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein E (TIGR02533; HMM-score: 144.4)
  Cell structure Cell envelope Surface structures type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 123.3)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 123.3)
  and 20 more
  Cell structure Cell envelope Surface structures twitching motility protein (TIGR01420; HMM-score: 91.9)
  Cellular processes Cellular processes Chemotaxis and motility twitching motility protein (TIGR01420; HMM-score: 91.9)
  Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid transfer ATPase TraJ (TIGR02525; HMM-score: 63)
  P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 55.7)
  helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 52.1)
  Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 50.3)
  Dot/Icm secretion system ATPase DotB (TIGR02524; HMM-score: 45.9)
  Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AA (TIGR02858; HMM-score: 28.1)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking putative secretion ATPase, PEP-CTERM locus subfamily (TIGR03015; HMM-score: 23.8)
  Metabolism Central intermediary metabolism Nitrogen metabolism urease accessory protein UreG (TIGR00101; HMM-score: 17.1)
  Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 15.2)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair checkpoint protein rad24 (TIGR00602; HMM-score: 14.5)
  Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 13.1)
  Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 12.8)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 12.6)
  Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 12.6)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 11.9)
  Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 11.9)
  Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.8)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.8)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 167.9)
  and 33 more
  AAA_14; AAA domain (PF13173; HMM-score: 22)
  Rad17; Rad17 P-loop domain (PF03215; HMM-score: 20.4)
  SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 20.3)
  TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 19.5)
  AAA_18; AAA domain (PF13238; HMM-score: 18.5)
  AAA_22; AAA domain (PF13401; HMM-score: 17.9)
  AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 17.7)
  AAA_23; AAA domain (PF13476; HMM-score: 17.7)
  AAA_16; AAA ATPase domain (PF13191; HMM-score: 16.1)
  AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 15.3)
  dNK; Deoxynucleoside kinase (PF01712; HMM-score: 15.1)
  Zeta_toxin; Zeta toxin (PF06414; HMM-score: 15)
  AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 15)
  cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 14.9)
  AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 14.5)
  AFG1_ATPase; AFG1-like ATPase (PF03969; HMM-score: 14.4)
  ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 14.4)
  AAA_33; AAA domain (PF13671; HMM-score: 14)
  Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 13.8)
  RNA_helicase; RNA helicase (PF00910; HMM-score: 13.7)
  ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 13.4)
  AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 13.3)
  NTPase_1; NTPase (PF03266; HMM-score: 13.1)
  AAA_25; AAA domain (PF13481; HMM-score: 13.1)
  AAA_30; AAA domain (PF13604; HMM-score: 13.1)
  NACHT; NACHT domain (PF05729; HMM-score: 12.8)
  PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 12.4)
  Spore_III_AA; Sporulation stage III, protein AA (PF19568; HMM-score: 12.4)
  Herpes_TK; Thymidine kinase from herpesvirus (PF00693; HMM-score: 12.3)
  AAA_28; AAA domain (PF13521; HMM-score: 12.3)
  APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 12.1)
  AAA_PrkA; PrkA AAA domain (PF08298; HMM-score: 11.8)
  GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 11.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.89
  • Cytoplasmic Membrane Score: 0.09
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003824
  • TAT(Tat/SPI): 0.000275
  • LIPO(Sec/SPII): 0.000446
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: BBA60011 NCBI
• UniProt:

⊟Protein sequence

• MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKIASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQVMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for D39, TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1863 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications