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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2019

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: SPNU_1819 [new locus tag: EL277_RS09610 ]
  • pan locus tag?: PNEUPAN003395000
  • symbol: msmE
  • pan gene symbol?: msmE
  • synonym:
  • product: Multiple sugar-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNU_1819 [new locus tag: EL277_RS09610 ]
  • symbol: msmE
  • product: Multiple sugar-binding protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1822594..1823844
  • length: 1251
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAAATGGTATAAGAAAGCAGGTTTTCTTTTAGTAGCTGGGGCTAGTTTACTAGGCCTA
    GCAGCTTGTGGTCAGAATAATCAATCGACTGATGGAAAGATAACGATTGAATTTTTTAAC
    CAGAAGACCGAAATGGCGGATACTTTGCAAAAAATTGTAGATAATTTTGAAAAGGATCAT
    CCTACTATTGATGTAAAACTGACGACTGTTCCGGCAGCTGGAATTGTTCTGAAGACTCGG
    ATTTTATCAGGAGATGTTCCAGATATTGTTAATATCTATCCTCAAAATATGGATTTTCAG
    GAGTGGGCAAAAGCAGGTTACTTTGCAGATATGACAGGGAAGTCCTATCTTGAGAATATT
    AAGAATGACTATGCCGAAAAGTATGCAATCAATAACAAGATTTATAGTGTACCTTTAACT
    GCTAACCTTTATGGAATCTATTACAATAAAACAAAGTTTAAAGAATTAGGACTTGAGGAA
    CCGAAGACTTTTAAAGAGTTTCAAGAGATTGTTAAAAAGATAAAAGATAGAGGGAATTCT
    CCGTTTGCAGTTGCAGGCAATGAAGGATGGACATTAAACGGTTATCACCAACTTTCTCTC
    ATTACTATTACAGGCAGTGGAGACGCAGCTAATAACTATCTTCGCTTTTCAAAACCAAAT
    GCTATTTCTGTAGATGATACTATTTTAAAAGCAGATGCAGAACGACTAGATTTGTTGGCA
    GACAATGCTCAAGATGGATGGCGTGGTGCCTCTTATAATGATGCTGTGGTAGCATTCTCG
    AATGAAAAAGCCTTGATGATGCCACAAGGATCATGGGCATTAGCGGCAATTAATCAACAG
    GATCCAAAATTTGATGTGGGGATGTTTGCCTTCCCAGGAGAAGAAGTAGGAAAAGATGTT
    ACTGTTGGTGCAGGGGACATGGCATTATCAACTTCAGCTACTACCAAACATCCTAAAGAA
    ACCGAGGAATTTATCAGCTATATGACTAGTCCAAAAGCTATGCAAGCATATTATGATGTG
    GATGGATCACCAGTTGCTGTAAAAGGTGTACAGGAAAAAGAAGATTCAGCGCTTGCAGAG
    ATTTCTAAACTAGCATTTACGGATAAACATTATGTTTGGTTGGGCCAACACTGGAATTCT
    GAAGAAGATTTTTTCAATCTAAGTGCAGGTTACTTGATGGATAAAAATCTGAAAAATATG
    GCAAACAATCTCAATGCTTTCTTTAATCCAATGAAGGCAGATTTGGACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1251

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNU_1819 [new locus tag: EL277_RS09610 ]
  • symbol: MsmE
  • description: Multiple sugar-binding protein
  • length: 416
  • theoretical pI: 4.76267
  • theoretical MW: 46149.8
  • GRAVY: -0.370913

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids carbohydrate ABC transporter substrate-binding protein, CPR_0540 family (TIGR03850; HMM-score: 84.7)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein (TIGR03851; HMM-score: 83.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞PFAM:
    PBP (CL0177) SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 144.9)
    SBP_bac_8; Bacterial extracellular solute-binding protein (PF13416; HMM-score: 130.5)
    and 4 more
    SBP_bac_6; Bacterial extracellular solute-binding protein (PF13343; HMM-score: 37.8)
    SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 25.4)
    no clan defined DUF4404; Domain of unknown function (DUF4404) (PF14357; HMM-score: 14)
    LppaM (CL0421) LPAM_2; Prokaryotic lipoprotein-attachment site (PF13627; HMM-score: 9.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • ⊞SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
    • SP(Sec/SPI): 0.00078
    • TAT(Tat/SPI): 0.000111
    • LIPO(Sec/SPII): 0.998865
    • Cleavage Site: CS pos: 22-23. LAA-CG. Pr: 0.9994
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBG35700 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKWYKKAGFLLVAGASLLGLAACGQNNQSTDGKITIEFFNQKTEMADTLQKIVDNFEKDHPTIDVKLTTVPAAGIVLKTRILSGDVPDIVNIYPQNMDFQEWAKAGYFADMTGKSYLENIKNDYAEKYAINNKIYSVPLTANLYGIYYNKTKFKELGLEEPKTFKEFQEIVKKIKDRGNSPFAVAGNEGWTLNGYHQLSLITITGSGDAANNYLRFSKPNAISVDDTILKADAERLDLLADNAQDGWRGASYNDAVVAFSNEKALMMPQGSWALAAINQQDPKFDVGMFAFPGEEVGKDVTVGAGDMALSTSATTKHPKETEEFISYMTSPKAMQAYYDVDGSPVAVKGVQEKEDSALAEISKLAFTDKHYVWLGQHWNSEEDFFNLSAGYLMDKNLKNMANNLNAFFNPMKADLD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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