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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 26-AUG-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC01340 [new locus tag: SPNOXC_RS00760 ]
  • pan locus tag?: PNEUPAN000788000
  • symbol: sdhB
  • pan gene symbol?: sdhB
  • synonym: sdaAB
  • product: putative L-serine dehydratase, beta chain

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC01340 [new locus tag: SPNOXC_RS00760 ]
  • symbol: sdhB
  • product: putative L-serine dehydratase, beta chain
  • replicon: chromosome
  • strand: -
  • coordinates: 134630..135301
  • length: 672
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAATCACTTCGTTTTCAATCTGTCTTTGATATCATCGGACCAGTTATGATTGGCCCA
    TCTAGTAGCCATACCGCTGGTGCTGTTCGTATTGGGAAGATTGTCTCTTCCATTTTTGAT
    GATACTCCGACAGAAGTTGAATTCCAACTTTTTAACTCATTTGCCAAGACCTATCGTGGT
    CACGGAACAGACCTAGCCCTTGTTGCAGGTATTTTGGGAATGGATACAGATGATCCTGAA
    ATTCCAAATAGTCTGGAAATTGCCCACAAGCGTGGTATCAAGATTGTCTGGACCATTCAG
    AAAGACAGCAATGCCCCTCACCCTAACACCACTAAAATTACTGTTAAAAATGCCCACAAG
    ACCATCAGCGTGACTGGTATTTCTATCGGTGGAGGAAATATTCAGGTAACCGAACTCAAT
    GGTTTTGCCGTCTCTCTCAATATGAATACACCGACTATCATCATCGTTCATCAAGATATT
    CCAGGTATGATTGCCCTTGTTACAGAGGCGCTTTCCCGCTATGGTATCAATATCGCCCAG
    ATGAATGTCACTCGTGAAAAAGCTGGTGAAAAAGCCATTATGATTATCGAAGTTGACAGT
    CGCAACTGTGATGAGGCTATCGAAGAAATTCGAAAAATCCCTCATCTCCACAATGTCAAT
    TTCTTTAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    672

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC01340 [new locus tag: SPNOXC_RS00760 ]
  • symbol: SdhB
  • description: putative L-serine dehydratase, beta chain
  • length: 223
  • theoretical pI: 6.96878
  • theoretical MW: 24328.8
  • GRAVY: -0.0044843

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines L-serine dehydratase, iron-sulfur-dependent, beta subunit (TIGR00719; EC 4.3.1.17; HMM-score: 229.7)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis L-serine dehydratase, iron-sulfur-dependent, beta subunit (TIGR00719; EC 4.3.1.17; HMM-score: 229.7)
    and 3 more
    Metabolism Amino acid biosynthesis Serine family phosphoglycerate dehydrogenase (TIGR01327; EC 1.1.1.95; HMM-score: 114.7)
    Metabolism Energy metabolism Amino acids and amines L-serine ammonia-lyase (TIGR00720; EC 4.3.1.17; HMM-score: 41.6)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis L-serine ammonia-lyase (TIGR00720; EC 4.3.1.17; HMM-score: 41.6)
  • ⊞TheSEED  :
    • L-serine dehydratase, beta subunit (EC 4.3.1.17)
    Amino Acids and Derivatives Alanine, serine, and glycine Glycine and Serine Utilization  L-serine dehydratase, beta subunit (EC 4.3.1.17)
    and 1 more
    Carbohydrates Central carbohydrate metabolism Pyruvate Alanine Serine Interconversions  L-serine dehydratase, beta subunit (EC 4.3.1.17)
  • ⊞PFAM:
    SDH_beta (CL0697) SDH_beta; Serine dehydratase beta chain (PF03315; HMM-score: 56.5)
    and 6 more
    ACT (CL0070) ACT; ACT domain (PF01842; HMM-score: 39.2)
    SDH_beta (CL0697) PGDH_inter; D-3-phosphoglycerate dehydrogenase intervening domain (PF19304; HMM-score: 22.7)
    ACT (CL0070) ACT_4; ACT domain (PF13291; HMM-score: 18.9)
    ACT_7; ACT domain (PF13840; HMM-score: 14.8)
    ACT_6; ACT domain (PF13740; HMM-score: 13.9)
    ACT_5; ACT domain (PF13710; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.257581
    • TAT(Tat/SPI): 0.034416
    • LIPO(Sec/SPII): 0.006775
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CBW31795 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKDSNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFFK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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