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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0919 [new locus tag: SPR_RS04600 ]
  • pan locus tag?: PNEUPAN002100000
  • symbol: dapA
  • pan gene symbol?: dapA
  • synonym:
  • product: Dihydrodipicolinate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0919 [new locus tag: SPR_RS04600 ]
  • symbol: dapA
  • product: Dihydrodipicolinate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 906411..907346
  • length: 936
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGTCTTATCAAGATTTAAAAGAGTGTAAAATCATCACAGCCTTTATTACTCCCTTCCAC
    GAGGATGGTTCCATCAACTTTGATGCTATTCCAGCCTTGATTGAGCATTTATTGGACCAT
    CATACGGATGGAATTCTTCTCGCAGGGACCACTGCTGAGAGTCCAACTTTGACCCACGAT
    GAGGAGTTGGAGTTATTTGCGGCTGTACAAAAGATTGTCAATGGACGAGTTCCTTTGATT
    GCGGGTGTAGGTACTAATGATACGCGTGACTCTATCGAGTTTGTCAAAGAAGTAGCGGAA
    TTCGGCGGTTTTGCTGCTGGTCTTGCTATTGTTCCTTACTACAACAAACCTTCTCAAGAA
    GGAATGTATCAGCATTTTAAAGCCATTGCAGATGCTTCTGACCTACCAATTATTATCTAT
    AACATTCCAGGGCGTGTGGTTGTTGAATTAACTCCAGAAACCATGCTTCGCTTGGCTGAT
    CATCCAAATATTATCGGTGTCAAAGAATGTACTAGCTTGGCTAATATGGCTTACTTGATT
    GAGCACAAACCAGAAGAGTTCTTGGTCTATACTGGTGAGGATGGAGATGCTTTCCATGCC
    ATGAACCTTGGGGCGGATGGGGTTATTTCTGTTGCCTCTCATACAAATGGGGATGAAATG
    CACGAGATGTTTATTGCCATTGCAGAAAGTGATGTGAAGAAAGCCGCAGCTATTCAACGT
    AAATTCATTCCTAAGGTTAATGCTCTCTTCTCTTATCCAAGTCCTGCTCCAGTTAAGGCA
    GTTTTGAACTACATGGGATTTGAAGCTGGACCAACTCGTCTACCTCTTGTTCCAGCACCA
    GAAGAAGATGCTAAACGCATTATCAAGGTTGTCGTAGATGGCGACTACGAAGCGACCAAG
    GCAACTGTAACAGGTGTCTTAAGACCAGATTACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    936

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0919 [new locus tag: SPR_RS04600 ]
  • symbol: DapA
  • description: Dihydrodipicolinate synthase
  • length: 311
  • theoretical pI: 4.55999
  • theoretical MW: 33893.5
  • GRAVY: 0.0237942

⊟Function[edit | edit source]

  • ⊞⊞reaction:
    EC 4.3.3.7?  ExPASy
    4-hydroxy-tetrahydrodipicolinate synthase Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H2O
  • ⊞⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family 4-hydroxy-tetrahydrodipicolinate synthase (TIGR00674; EC 4.3.3.7; HMM-score: 301)
    and 4 more
    2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (TIGR02313; EC 4.1.2.-; HMM-score: 201.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides N-acetylneuraminate lyase (TIGR00683; EC 4.1.3.3; HMM-score: 119.4)
    Metabolism Central intermediary metabolism Amino sugars N-acetylneuraminate lyase (TIGR00683; EC 4.1.3.3; HMM-score: 119.4)
    5-dehydro-4-deoxyglucarate dehydratase (TIGR03249; EC 4.2.1.41; HMM-score: 92.8)
  • TheSEED  :
    • 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Lysine Biosynthesis DAP Pathway  4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)
  • ⊞⊞PFAM:
    TIM_barrel (CL0036) DHDPS; Dihydrodipicolinate synthetase family (PF00701; HMM-score: 279.9)
    and 1 more
    Periplas_BP (CL0144) Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002319
    • TAT(Tat/SPI): 0.000202
    • LIPO(Sec/SPII): 0.000249
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLDHHTDGILLAGTTAESPTLTHDEELELFAAVQKIVNGRVPLIAGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKAIADASDLPIIIYNIPGRVVVELTPETMLRLADHPNIIGVKECTSLANMAYLIEHKPEEFLVYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFIAIAESDVKKAAAIQRKFIPKVNALFSYPSPAPVKAVLNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞⊞regulator: CodY (repression) regulon

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=spr0919&oldid=129578"
Insert paragraph

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0919 [new locus tag: SPR_RS04600 ]
  • pan locus tag?: PNEUPAN002100000
  • symbol: dapA
  • pan gene symbol?: dapA
  • synonym:
  • product: Dihydrodipicolinate synthase

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0919 [new locus tag: SPR_RS04600 ]
  • symbol: dapA
  • product: Dihydrodipicolinate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 906411..907346
  • length: 936
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGTCTTATCAAGATTTAAAAGAGTGTAAAATCATCACAGCCTTTATTACTCCCTTCCAC
    GAGGATGGTTCCATCAACTTTGATGCTATTCCAGCCTTGATTGAGCATTTATTGGACCAT
    CATACGGATGGAATTCTTCTCGCAGGGACCACTGCTGAGAGTCCAACTTTGACCCACGAT
    GAGGAGTTGGAGTTATTTGCGGCTGTACAAAAGATTGTCAATGGACGAGTTCCTTTGATT
    GCGGGTGTAGGTACTAATGATACGCGTGACTCTATCGAGTTTGTCAAAGAAGTAGCGGAA
    TTCGGCGGTTTTGCTGCTGGTCTTGCTATTGTTCCTTACTACAACAAACCTTCTCAAGAA
    GGAATGTATCAGCATTTTAAAGCCATTGCAGATGCTTCTGACCTACCAATTATTATCTAT
    AACATTCCAGGGCGTGTGGTTGTTGAATTAACTCCAGAAACCATGCTTCGCTTGGCTGAT
    CATCCAAATATTATCGGTGTCAAAGAATGTACTAGCTTGGCTAATATGGCTTACTTGATT
    GAGCACAAACCAGAAGAGTTCTTGGTCTATACTGGTGAGGATGGAGATGCTTTCCATGCC
    ATGAACCTTGGGGCGGATGGGGTTATTTCTGTTGCCTCTCATACAAATGGGGATGAAATG
    CACGAGATGTTTATTGCCATTGCAGAAAGTGATGTGAAGAAAGCCGCAGCTATTCAACGT
    AAATTCATTCCTAAGGTTAATGCTCTCTTCTCTTATCCAAGTCCTGCTCCAGTTAAGGCA
    GTTTTGAACTACATGGGATTTGAAGCTGGACCAACTCGTCTACCTCTTGTTCCAGCACCA
    GAAGAAGATGCTAAACGCATTATCAAGGTTGTCGTAGATGGCGACTACGAAGCGACCAAG
    GCAACTGTAACAGGTGTCTTAAGACCAGATTACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    936

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0919 [new locus tag: SPR_RS04600 ]
  • symbol: DapA
  • description: Dihydrodipicolinate synthase
  • length: 311
  • theoretical pI: 4.55999
  • theoretical MW: 33893.5
  • GRAVY: 0.0237942

Insert paragraph

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 4.3.3.7?  ExPASy
    4-hydroxy-tetrahydrodipicolinate synthase Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H2O
  • ⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family 4-hydroxy-tetrahydrodipicolinate synthase (TIGR00674; EC 4.3.3.7; HMM-score: 301)
    and 4 more
    2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (TIGR02313; EC 4.1.2.-; HMM-score: 201.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides N-acetylneuraminate lyase (TIGR00683; EC 4.1.3.3; HMM-score: 119.4)
    Metabolism Central intermediary metabolism Amino sugars N-acetylneuraminate lyase (TIGR00683; EC 4.1.3.3; HMM-score: 119.4)
    5-dehydro-4-deoxyglucarate dehydratase (TIGR03249; EC 4.2.1.41; HMM-score: 92.8)
  • TheSEED  :
    • 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Lysine Biosynthesis DAP Pathway  4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)
  • ⊞PFAM:
    TIM_barrel (CL0036) DHDPS; Dihydrodipicolinate synthetase family (PF00701; HMM-score: 279.9)
    and 1 more
    Periplas_BP (CL0144) Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 12.3)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002319
    • TAT(Tat/SPI): 0.000202
    • LIPO(Sec/SPII): 0.000249
  • predicted transmembrane helices (TMHMM): 0

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLDHHTDGILLAGTTAESPTLTHDEELELFAAVQKIVNGRVPLIAGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKAIADASDLPIIIYNIPGRVVVELTPETMLRLADHPNIIGVKECTSLANMAYLIEHKPEEFLVYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFIAIAESDVKKAAAIQRKFIPKVNALFSYPSPAPVKAVLNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • ⊞regulator: CodY (repression) regulon

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph