⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 05-OCT-2017

⊟Summary

• organism: Streptococcus pneumoniae MDRSPN001
locus tag: MDRSPN_00266 [new locus tag: MDRSPN_RS01420 ]
pan locus tag^?: PNEUPAN001023000
symbol: adhP
pan gene symbol^?: adhA
• synonym:
• product: zinc-dependent alcohol dehydrogenase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MDRSPN_00266 [new locus tag: MDRSPN_RS01420 ]
• symbol: adhP
• product: zinc-dependent alcohol dehydrogenase
• replicon: chromosome
• strand: -
• coordinates: 256743..257762
• length: 1020
• essential: unknown

⊟Accession numbers

• Location: AP018391 (256743..257762) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0265 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  
  ATGAAAGCTGTTGTTGTAAATCCAGAAAGCACTGGTGTTGCTATTGAAGAAAAAGTACTC
  CGTCCACTTGAAACTGGGGAAGCACTTGTAGAAGTTGAATACTGTGGCGTTTGCCACACC
  GACCTCCACGTTGCTCATGGTGACTTTGGTCAAGTCCCAGGACGTGTTCTTGGGCACGAA
  GGTATCGGTATCGTTAAAGAGATTGCTCCAGATGTGAAAAGCCTTAAAGTCGGTGACCGC
  GTCAGCGTTGCTTGGTTCTTTGAAGGATGTGGCACTTGCGAATACTGTACAACTGGTCGC
  GAAACCCTTTGCCGTACAGTGAAAAATGCTGGCTACTCAGTAGACGGTGGTATGGCTGAA
  CAATGTATCGTAACTGCTGACTATGCTGTCAAAGTTCCTGACGGACTTGATCCAGCCCAA
  GCTTCTTCTATCACATGTGCTGGAGTAACAACCTATAAAGCTATCAAAGAAGCAAAAGTT
  GAACCAGGCCAATGGGTTGTTCTTTACGGTGCTGGTGGACTTGGTAACCTCGCTGTTCAA
  TACGCTAAAAAAGTATTCAATGCTCATGTTATCGCAGTCGATATCAACAATGACAAACTT
  ACCCTTGCAAAAGAAGTAGGCGCTGACATTGTGATTAACGGCCTCGAAGTTGAAGATGTA
  GCTGGACTCATTAAAGAAAAAACTGATGGAGGAGCTCATTCAGCTGTCGTAACTGCTGTG
  TCTAAAGTTGCCTTCAACCAGGCTGTTGACTCCATTCGTGCTGGTGGTCGCGTCGTCGCT
  GTTGGTCTTCCTTCTGAAATGATGGAACTCAGCATCGTTAAAACAGTCCTCGATGGAATC
  CAAGTCATCGGTTCTCTTGTCGGAACTCGTAAAGACTTAGAAGAAGCCTTCCAATTTGGT
  GCAGAAGGTCTGGTAGTCCCAGTTGTTCAAAAACGTCCAGTAGAAGATGCTGTTGCCATT
  TTCGACGAAATGGAAAAAGGCCAAATCCAAGGACGTATGGTACTCGACTTCACCCACTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  

⊟Protein

⊟General

• locus tag: MDRSPN_00266 [new locus tag: MDRSPN_RS01420 ]
• symbol: AdhP
• description: zinc-dependent alcohol dehydrogenase
• length: 339
• theoretical pI: 4.69885
• theoretical MW: 35779.8
• GRAVY: 0.176106

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02822; EC 1.-.-.-; HMM-score: 149.3)
  Metabolism Energy metabolism Amino acids and amines L-threonine 3-dehydrogenase (TIGR00692; EC 1.1.1.103; HMM-score: 134.6)
  Cellular processes Cellular processes Detoxification S-(hydroxymethyl)mycothiol dehydrogenase (TIGR03451; EC 1.1.1.306; HMM-score: 128.1)
  Unknown function Enzymes of unknown specificity NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family (TIGR03989; EC 1.1.99.36; HMM-score: 128.1)
  putative phosphonate catabolism associated alcohol dehydrogenase (TIGR03366; HMM-score: 122.2)
  and 9 more
  6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 117.4)
  Unknown function Enzymes of unknown specificity putative NAD(P)H quinone oxidoreductase, PIG3 family (TIGR02824; HMM-score: 103.3)
  Cellular processes Cellular processes Detoxification S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 99.8)
  Metabolism Energy metabolism Fermentation S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 99.8)
  Unknown function Enzymes of unknown specificity putative quinone oxidoreductase, YhdH/YhfP family (TIGR02823; HMM-score: 65.5)
  crotonyl-CoA carboxylase/reductase (TIGR01751; EC 1.3.1.85; HMM-score: 61)
  Metabolism Central intermediary metabolism One-carbon metabolism formaldehyde dehydrogenase, glutathione-independent (TIGR02819; EC 1.2.1.46; HMM-score: 58.1)
  Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02817; HMM-score: 48.2)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 12.3)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• ⊞⊞PFAM:
  GroES (CL0296) ADH_N; Alcohol dehydrogenase GroES-like domain (PF08240; HMM-score: 104.1)
  NADP_Rossmann (CL0063) ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 86.8)
  and 2 more
  ADH_zinc_N_2; Zinc-binding dehydrogenase (PF13602; HMM-score: 36.7)
  Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 14.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9565
  • Cytoplasmic Membrane Score: 0.008
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.0353
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.009474
  • TAT(Tat/SPI): 0.000473
  • LIPO(Sec/SPII): 0.000942
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: BBA58472 NCBI
• UniProt:

⊟Protein sequence

• MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKVEPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLTLAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAVSKVAFNQAVDSIRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAIFDEMEKGQIQGRMVLDFTH

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0265 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications