⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 05-OCT-2017

⊟Summary

• organism: Streptococcus pneumoniae MDRSPN001
locus tag: MDRSPN_00973 [new locus tag: MDRSPN_RS05080 ]
pan locus tag^?: PNEUPAN002272000
symbol: serB
pan gene symbol^?: serB
• synonym:
• product: phosphoserine phosphatase SerB

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MDRSPN_00973 [new locus tag: MDRSPN_RS05080 ]
• symbol: serB
• product: phosphoserine phosphatase SerB
• replicon: chromosome
• strand: +
• coordinates: 981008..981652
• length: 645
• essential: unknown

⊟Accession numbers

• Location: AP018391 (981008..981652) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1009 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  
  ATGTCTCAAGTAATGGGGCTCTGTGTCATGGACGTTGACGGAACCCTGATAGCAGAGGAA
  GTGATTGATCTTTTAGGAAGAGAAGCAGGTTGCGAAGAAGAAATTTCGCAGATTACAAGA
  CAGGCAATGCGAGGTGAACTGGACTTTGAAACAAGTTTACGAGCGAGGGTAGCTTTGTTA
  AAAGGCCTTCCGGTTTCGGTCTTTGATACTGTCTTCAAATCCATTCATCTGTCCAAGAAT
  GCTCAAGAATTTATCTACATCCTTCAAAAGAAGGGTATTCTAGTCGGTCTAGTGTCTGGT
  GGATTTGCACCAATAGTTGAGAGATTAGCAAAATCCCTTGGTATTTCCTATTTCTCCGCC
  AACCAGTTAGAAGTCAAAGACGGATTTTTAACAGGAAAATTAGTTGGTAAAATTGTGACA
  AGTCAAGTAAAAAATGCTACTCTTGAGAAATGGAGAAAGGAATTAGGACTTTCCAAAGAA
  AGAACGATTGCCATCGGTGATGGTGCTAACGACCTCTTGATGCTAAAGTCAGCAGGACGT
  GGTATTGCATTTTGTGCCAAAGAATTCGTAAAATCTGAGATAGCTTGTCATGTAGATAAA
  AGGGATTTTTTGGAAGCTCTACCTTTGATTGATTTCTTAGAATGA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  645
  

⊟Protein

⊟General

• locus tag: MDRSPN_00973 [new locus tag: MDRSPN_RS05080 ]
• symbol: SerB
• description: phosphoserine phosphatase SerB
• length: 214
• theoretical pI: 5.88849
• theoretical MW: 23452.3
• GRAVY: 0.188318

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 229.6)
  and 23 more
  Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 111.5)
  phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 91.5)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 63.4)
  Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 51.2)
  phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 45)
  phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein (TIGR02137; EC 3.1.3.3; HMM-score: 34.8)
  HAD ATPase, P-type, family IC (TIGR01494; EC 3.6.3.-; HMM-score: 30.4)
  Metabolism Central intermediary metabolism Other 2,3-diketo-5-methylthio-1-phosphopentane phosphatase (TIGR01489; HMM-score: 30.2)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 28.7)
  Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 28.5)
  Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 28.5)
  sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 26.4)
  heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 22.1)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 21.4)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 18.7)
  HAD phosphatase, family IIIC (TIGR01681; HMM-score: 16.2)
  mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 15.5)
  Unknown function General mannosyl-3-phosphoglycerate phosphatase homolog (TIGR02463; EC 3.1.3.-; HMM-score: 15.2)
  phospholipid-translocating P-type ATPase, flippase (TIGR01652; EC 3.6.3.1; HMM-score: 14)
  Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 13.2)
  Metabolism Amino acid biosynthesis Aspartate family 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (TIGR03333; EC 3.1.3.-; HMM-score: 12.5)
  Metabolism Central intermediary metabolism Sulfur metabolism 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (TIGR03333; EC 3.1.3.-; HMM-score: 12.5)
  P-type ATPase of unknown pump specificity (type V) (TIGR01657; HMM-score: 12)
• TheSEED:
• ⊞⊞PFAM:
  HAD (CL0137) HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 83.1)
  Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 67.7)
  and 6 more
  Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 47.3)
  HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 28.3)
  no clan defined Peptidase_C74; Pestivirus NS2 peptidase (PF12387; HMM-score: 17.3)
  HAD (CL0137) S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 14.6)
  Put_Phosphatase; Putative Phosphatase (PF06888; HMM-score: 14.5)
  no clan defined PMT2_N; Phosphoethanolamine N-methyltransferase 2 N-terminal (PF17987; HMM-score: 14.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.005148
  • TAT(Tat/SPI): 0.000189
  • LIPO(Sec/SPII): 0.000739
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: BBA59176 NCBI
• UniProt:

⊟Protein sequence

• MSQVMGLCVMDVDGTLIAEEVIDLLGREAGCEEEISQITRQAMRGELDFETSLRARVALLKGLPVSVFDTVFKSIHLSKNAQEFIYILQKKGILVGLVSGGFAPIVERLAKSLGISYFSANQLEVKDGFLTGKLVGKIVTSQVKNATLEKWRKELGLSKERTIAIGDGANDLLMLKSAGRGIAFCAKEFVKSEIACHVDKRDFLEALPLIDFLE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1009 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications