⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 05-OCT-2017

⊟Summary

• organism: Streptococcus pneumoniae MDRSPN001
locus tag: MDRSPN_01231 [new locus tag: MDRSPN_RS06485 ]
pan locus tag^?: PNEUPAN002834000
symbol: atpA
pan gene symbol^?: atpA
• synonym:
• product: ATP synthase subunit alpha

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MDRSPN_01231 [new locus tag: MDRSPN_RS06485 ]
• symbol: atpA
• product: ATP synthase subunit alpha
• replicon: chromosome
• strand: -
• coordinates: 1249409..1250914
• length: 1506
• essential: unknown other strains

⊟Accession numbers

• Location: AP018391 (1249409..1250914) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1337 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  1441
  1501
  
  TTGGCAATTAACGCACAAGAAATCAGCGCTTTAATTAAGCAACAAATTGAAAATTTCAAA
  CCCAATTTTGATGTGACTGAAACAGGTGTTGTAACCTATATCGGGGACGGTATCGCGCGT
  GCTCATGGCCTTGAAAATGTCATGAGTGGAGAGTTGTTGAATTTTGAAAACGGCTCTTAT
  GGTATGGCTCAAAACTTGGAGTCAACAGACGTTGGTATTATCATCCTAGGTGACTTTACA
  GATATCCGTGAAGGCGATACAATCCGCCGTACAGGGAAAATCATGGAAGTCCCTGTAGGT
  GAAAGTCTGATTGGTCGTGTTGTGGATCCGCTTGGTCGTCCAGTTGACGGTCTTGGAGAA
  ATCCACACTGATAAAACTCGTCCAGTAGAAGCACCAGCTCCTGGTGTTATGCAACGTAAG
  TCTGTTTCAGAACCATTGCAAACTGGTTTGAAAGCTATTGACGCCCTTGTACCGATTGGT
  CGTGGTCAACGTGAGTTGATTATCGGTGACCGTCAGACAGGGAAAACAACCATTGCGATT
  GATACAATCTTGAACCAAAAAGATCAAGATATGATCTGTATCTACGTCGCGATTGGACAA
  AAAGAATCAACAGTTCGTACGCAAGTAGAAACACTTCGTCAGTACGGTGCCTTGGACTAC
  ACAATCGTTGTGACAGCCTCTGCTTCACAACCATCTCCATTGCTCTTCCTAGCTCCTTAT
  GCTGGGGTTGCTATGGCGGAAGAATTTATGTATCAAGGTAAGCATGTTTTGATTGTATAC
  GATGATCTATCAAAACAAGCGGTAGCTTATCGTGAACTGTCGCTCTTGCTTCGTCGTCCT
  CCAGGTCGTGAAGCCTTCCCAGGGGATGTTTTCTATCTCCACAGCCGTTTGCTTGAGCGC
  TCAGCTAAAGTTTCTGATGAACTTGGTGGTGGATCAATTACAGCCCTACCATTTATCGAG
  ACACAAGCAGGAGATATCTCAGCCTATATCGCAACCAACGTGATTTCTATCACTGATGGA
  CAAATCTTCCTTGGCGATGGCCTCTTCAATGCAGGTATTCGTCCAGCCATCGATGCGGGT
  TCATCTGTATCTCGTGTAGGTGGTTCTGCACAAATCAAAGCCATGAAGAAGGTTGCTGGT
  ACACTTCGTATCGACCTTGCTTCATACCGTGAGTTGGAAGCCTTTACTAAGTTTGGTTCT
  GACTTGGACGCAGCAACACAGGCTAAGTTGAACCGTGGACGTCGTACCGTTGAGGTCTTG
  AAACAACCTGTTCACAAACCATTACCTGTTGAGAAACAAGTAACCATTCTTTATGCTTTG
  ACACATGGTTTCTTGGATACTGTTCCAGTAGATGATATTGTTCGTTTCGAGGAAGAGTTC
  CATGCCTTCTTTGATGCTCAACATCCAGAGATTTTGGAAACCATTCGTGATACAAAAGAC
  TTGCCAGAAGAAGCAGTCTTGGATGCTGCGATTACAGAGTTTCTCAATCAATCTAGCTTC
  CAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1380
  1440
  1500
  1506
  

⊟Protein

⊟General

• locus tag: MDRSPN_01231 [new locus tag: MDRSPN_RS06485 ]
• symbol: AtpA
• description: ATP synthase subunit alpha
• length: 501
• theoretical pI: 4.72226
• theoretical MW: 54644.8
• GRAVY: -0.0766467

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, alpha subunit (TIGR00962; EC 3.6.3.14; HMM-score: 817.9)
  and 15 more
  alternate F1F0 ATPase, F1 subunit alpha (TIGR03324; EC 3.6.3.-; HMM-score: 643.8)
  Cellular processes Cellular processes Pathogenesis type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 214.9)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 214.9)
  Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03496; EC 3.6.3.14; HMM-score: 196.6)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATPase, FliI/YscN family (TIGR01026; EC 3.6.3.14; HMM-score: 182.3)
  Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03497; EC 3.6.3.14; HMM-score: 178.7)
  flagellar protein export ATPase FliI (TIGR03498; EC 3.6.3.14; HMM-score: 171.2)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, B subunit (TIGR01041; EC 3.6.3.14; HMM-score: 133.3)
  Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, B subunit (TIGR01040; EC 3.6.3.14; HMM-score: 113.5)
  alternate F1F0 ATPase, F1 subunit beta (TIGR03305; EC 3.6.3.-; HMM-score: 113)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, beta subunit (TIGR01039; EC 3.6.3.14; HMM-score: 105.6)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, A subunit (TIGR01043; EC 3.6.3.14; HMM-score: 68.7)
  Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, A subunit (TIGR01042; EC 3.6.3.14; HMM-score: 52.6)
  Genetic information processing Transcription Transcription factors transcription termination factor Rho (TIGR00767; EC 3.6.4.-; HMM-score: 21.3)
  KaiC domain protein, PAE1156 family (TIGR03881; HMM-score: 13.3)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) ATP-synt_ab; ATP synthase alpha/beta family, nucleotide-binding domain (PF00006; HMM-score: 235.7)
  and 4 more
  no clan defined ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain (PF00306; HMM-score: 163)
  HAS-barrel (CL0275) ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain (PF02874; HMM-score: 58.3)
  P-loop_NTPase (CL0023) ATPase; KaiC (PF06745; HMM-score: 21.9)
  AAA_14; AAA domain (PF13173; HMM-score: 13.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.007391
  • TAT(Tat/SPI): 0.000235
  • LIPO(Sec/SPII): 0.000328
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: BBA59430 NCBI
• UniProt:

⊟Protein sequence

• MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGLENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGESLIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGALDYTIVVTASASQPSPLLFLAPYAGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNVISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYRELEAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPVDDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1337 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications