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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1510 [new locus tag: SP_RS07435 ]
  • pan locus tag?: PNEUPAN002792000
  • symbol: atpA
  • pan gene symbol?: atpA
  • synonym:
  • product: ATP synthase F1, alpha subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1510 [new locus tag: SP_RS07435 ]
  • symbol: atpA
  • product: ATP synthase F1, alpha subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 1418861..1420366
  • length: 1506
  • essential: yes [1] other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    TTGGCAATTAACGCACAAGAAATCAGCGCTTTAATTAAGCAACAAATTGAAAATTTCAAA
    CCCAATTTTGATGTGACTGAAACAGGTGTTGTAACCTATATCGGGGACGGTATCGCGCGT
    GCTCACGGCCTTGAAAATGTCATGAGTGGAGAGTTGTTGAATTTTGAAAACGGCTCTTAT
    GGTATGGCTCAAAACTTGGAGTCAACAGACGTTGGTATTATCATCCTAGGTGACTTTACA
    GATATCCGTGAAGGCGATACAATCCGCCGTACAGGGAAAATCATGGAAGTCCCTGTAGGT
    GAAAGTCTGATTGGTCGTGTTGTGGATCCGCTTGGTCGTCCAGTTGACGGTCTTGGAGAA
    ATCCACACTGATAAAACTCGTCCAGTAGAAGCACCAGCTCCTGGTGTTATGCAACGTAAG
    TCTGTTTCAGAACCATTGCAAACTGGTTTGAAAGCTATTGACGCCCTTGTACCGATTGGT
    CGTGGTCAACGTGAGTTGATTATCGGTGACCGTCAGACAGGGAAAACAACCATTGCGATT
    GATACAATCTTGAACCAAAAAGATCAAGATATGATCTGTATCTACGTCGCGATTGGACAA
    AAAGAATCAACAGTTCGTACGCAAGTAGAAACACTTCGTCAGTACGGTGCCTTGGACTAC
    ACAATCGTTGTGACAGCCTCTGCTTCACAACCATCTCCATTGCTCTTCCTAGCTCCTTAT
    GCTGGGGTTGCTATGGCGGAAGAATTTATGTATCAAGGTAAGCATGTTTTGATTGTATAC
    GATGATCTATCAAAACAAGCGGTAGCTTATCGTGAACTGTCGCTCTTGCTTCGTCGTCCT
    CCAGGTCGTGAAGCCTTCCCAGGGGATGTTTTCTATCTCCACAGCCGTTTGCTTGAGCGC
    TCAGCTAAAGTTTCTGATGAACTTGGTGGTGGATCAATTACAGCCCTACCATTTATCGAG
    ACACAAGCAGGAGATATCTCAGCCTATATCGCAACCAACGTGATTTCTATCACTGATGGA
    CAAATCTTCCTTGGCGATGGCCTCTTCAATGCAGGTATTCGTCCAGCCATCGATGCGGGT
    TCATCTGTATCTCGTGTAGGTGGTTCTGCACAAATCAAAGCCATGAAGAAGGTTGCTGGT
    ACACTTCGTATCGACCTTGCTTCATACCGTGAGTTGGAAGCCTTTACTAAGTTTGGTTCT
    GACTTGGACGCAGCAACACAGGCTAAGTTGAACCGTGGACGTCGTACCGTTGAGGTCTTG
    AAACAACCTGTTCACAAACCATTACCTGTTGAGAAACAAGTAACCATTCTTTATGCTTTG
    ACACATGGTTTCTTGGATACTGTTCCAGTAGATGATATTGTTCGTTTCGAGGAAGAGTTC
    CATGCCTTCTTTGATGCTCAACATCCAGAGATTTTGGAAACCATTCGTGATACAAAAGAC
    TTGCCAGAAGAAGCAGTCTTGGATGCTGCGATTACAGAGTTTCTCAATCAATCTAGCTTC
    CAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1506

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1510 [new locus tag: SP_RS07435 ]
  • symbol: AtpA
  • description: ATP synthase F1, alpha subunit
  • length: 501
  • theoretical pI: 4.72226
  • theoretical MW: 54644.8
  • GRAVY: -0.0766467

⊟Function[edit | edit source]

  • reaction:
    EC 3.6.3.14?  ExPASy
    H+-transporting two-sector ATPase ATP + H2O + H+(In) = ADP + phosphate + H+(Out)
  • TIGRFAM:
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, alpha subunit (TIGR00962; EC 3.6.3.14; HMM-score: 817.9)
    and 15 more
    alternate F1F0 ATPase, F1 subunit alpha (TIGR03324; EC 3.6.3.-; HMM-score: 643.8)
    Cellular processes Cellular processes Pathogenesis type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 214.9)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 214.9)
    Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03496; EC 3.6.3.14; HMM-score: 196.6)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATPase, FliI/YscN family (TIGR01026; EC 3.6.3.14; HMM-score: 182.3)
    Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03497; EC 3.6.3.14; HMM-score: 178.7)
    flagellar protein export ATPase FliI (TIGR03498; EC 3.6.3.14; HMM-score: 171.2)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, B subunit (TIGR01041; EC 3.6.3.14; HMM-score: 133.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, B subunit (TIGR01040; EC 3.6.3.14; HMM-score: 113.5)
    alternate F1F0 ATPase, F1 subunit beta (TIGR03305; EC 3.6.3.-; HMM-score: 113)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, beta subunit (TIGR01039; EC 3.6.3.14; HMM-score: 105.6)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, A subunit (TIGR01043; EC 3.6.3.14; HMM-score: 68.7)
    Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, A subunit (TIGR01042; EC 3.6.3.14; HMM-score: 52.6)
    Genetic information processing Transcription Transcription factors transcription termination factor Rho (TIGR00767; EC 3.6.4.-; HMM-score: 21.3)
    KaiC domain protein, PAE1156 family (TIGR03881; HMM-score: 13.3)
  • TheSEED  :
    • ATP synthase alpha chain (EC 7.1.2.2)
    Respiration ATP synthases F0F1-type ATP synthase  ATP synthase alpha chain (EC 3.6.3.14)
  • PFAM:
    P-loop_NTPase (CL0023) ATP-synt_ab; ATP synthase alpha/beta family, nucleotide-binding domain (PF00006; HMM-score: 235.7)
    and 4 more
    no clan defined ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain (PF00306; HMM-score: 163)
    HAS-barrel (CL0275) ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain (PF02874; HMM-score: 58.3)
    P-loop_NTPase (CL0023) ATPase; KaiC (PF06745; HMM-score: 21.9)
    AAA_14; AAA domain (PF13173; HMM-score: 13.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.5417
    • Cytoplasmic Membrane Score: 0.3263
    • Cell wall & surface Score: 0.0013
    • Extracellular Score: 0.1307
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007391
    • TAT(Tat/SPI): 0.000235
    • LIPO(Sec/SPII): 0.000328
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGLENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGESLIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGALDYTIVVTASASQPSPLLFLAPYAGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNVISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYRELEAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPVDDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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