⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 26-AUG-2017

⊟Summary

• organism: Streptococcus pneumoniae OXC141
locus tag: SPNOXC04100 [new locus tag: SPNOXC_RS02220 ]
pan locus tag^?: PNEUPAN001292000
symbol: fabE
pan gene symbol^?: accB
• synonym:
• product: biotin carboxyl carrier protein of acetyl-CoA carboxylase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNOXC04100 [new locus tag: SPNOXC_RS02220 ]
• symbol: fabE
• product: biotin carboxyl carrier protein of acetyl-CoA carboxylase
• replicon: chromosome
• strand: +
• coordinates: 407979..408464
• length: 486
• essential: unknown other strains

⊟Accession numbers

• Location: FQ312027 (407979..408464) NCBI
• BioCyc: see SPNOXC_RS02220
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0386 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  
  ATGAATTTAAACGATATTAAAGACTTGATGACTCAATTTGACCAGTCAAGTTTGAGAGAA
  TTTTCTTATAAAAATGGGACGGATGAGTTGCAGTTTAGCAAGAATGAAGCGAGACCTGTG
  CCTGAAGTTGCAACTCAAGTCGCTCCAGCACCCGTTCTAGCAACACCGAGTCCAGTAGCT
  CCTACATCTGCTCCAGCAGAGACTGTAGCAGAAGAAGTTCCAGCTCCAGCTGAAGCAAGT
  GTGGCTAGTGAGGGAAATCTTGTAGAGAGTCCACTTGTTGGAGTGGTTTACTTGGCTGCT
  GGACCAGATAAACCTGCCTTCGTTACAGTTGGTGATAGTGTCAAAAAAGGTCAAACATTG
  GTAATTATCGAAGCCATGAAAGTCATGAATGAAATCCCAGCTCCTAAGGATGGTGTGGTA
  ACGGAAATTCTCGTCTCTAACGAAGAAATGGTTGAGTTTGGTAAAGGATTGGTACGTATC
  AAATGA
  60
  120
  180
  240
  300
  360
  420
  480
  486
  

⊟Protein

⊟General

• locus tag: SPNOXC04100 [new locus tag: SPNOXC_RS02220 ]
• symbol: FabE
• description: biotin carboxyl carrier protein of acetyl-CoA carboxylase
• length: 161
• theoretical pI: 4.17105
• theoretical MW: 17019.3
• GRAVY: -0.0198758

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, biotin carboxyl carrier protein (TIGR00531; HMM-score: 139.5)
  and 13 more
  Metabolism Transport and binding proteins Cations and iron carrying compounds oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 40.6)
  Metabolism Energy metabolism Other oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 40.6)
  Metabolism Central intermediary metabolism Nitrogen metabolism urea carboxylase (TIGR02712; EC 6.3.4.6; HMM-score: 40.6)
  Metabolism Energy metabolism Pyruvate dehydrogenase dihydrolipoyllysine-residue acetyltransferase (TIGR01348; EC 2.3.1.12; HMM-score: 34.9)
  Metabolism Energy metabolism Glycolysis/gluconeogenesis pyruvate carboxylase (TIGR01235; EC 6.4.1.1; HMM-score: 31.6)
  Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 31.3)
  2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase (TIGR02927; EC 2.3.1.61; HMM-score: 27.8)
  Metabolism Transport and binding proteins Unknown substrate efflux transporter, RND family, MFP subunit (TIGR01730; HMM-score: 24.4)
  glycine cleavage protein H-like protein (TIGR03077; HMM-score: 16.2)
  Metabolism Energy metabolism Amino acids and amines glycine cleavage system H protein (TIGR00527; HMM-score: 16.1)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion membrane fusion protein, HlyD family (TIGR01843; HMM-score: 12.7)
  Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system secretion protein (TIGR03794; HMM-score: 11.3)
  Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system secretion protein (TIGR03794; HMM-score: 11.3)
• ⊞⊞TheSEED  :
  • Biotin carboxyl carrier protein of acetyl-CoA carboxylase
  Fatty Acids, Lipids, and Isoprenoids Fatty acids Fatty Acid Biosynthesis FASII  Biotin carboxyl carrier protein of acetyl-CoA carboxylase
  and 1 more
  Miscellaneous Miscellaneous - no subcategory EC 6.3.4.- Ligases that form carbon-nitrogen bonds  Biotin carboxyl carrier protein of acetyl-CoA carboxylase
• ⊞⊞PFAM:
  Hybrid (CL0105) Biotin_lipoyl; Biotin-requiring enzyme (PF00364; HMM-score: 72.8)
  and 6 more
  Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 24.9)
  GCV_H; Glycine cleavage H-protein (PF01597; HMM-score: 21.2)
  RnfC_N; RnfC Barrel sandwich hybrid domain (PF13375; HMM-score: 17.3)
  HlyD_D23; Barrel-sandwich domain of CusB or HlyD membrane-fusion (PF16576; HMM-score: 14.6)
  no clan defined DEC-1_N; DEC-1 protein, N-terminal region (PF04625; HMM-score: 12.5)
  POTRA (CL0191) YqfD; Putative stage IV sporulation protein YqfD (PF06898; HMM-score: 10.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.027977
  • TAT(Tat/SPI): 0.069952
  • LIPO(Sec/SPII): 0.00266
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CBW32069 NCBI
• UniProt:

⊟Protein sequence

• MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVATQVAPAPVLATPSPVAPTSAPAETVAEEVPAPAEASVASEGNLVESPLVGVVYLAAGPDKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEMVEFGKGLVRIK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0386 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications