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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1566 [new locus tag: SPR_RS07775 ]
  • pan locus tag?: PNEUPAN003129000
  • symbol: scrA
  • pan gene symbol?: scrA
  • synonym:
  • product: Phosphotransferase system enzyme II

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1566 [new locus tag: SPR_RS07775 ]
  • symbol: scrA
  • product: Phosphotransferase system enzyme II
  • replicon: chromosome
  • strand: -
  • coordinates: 1546504..1548387
  • length: 1884
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    ATGAACAATCAGGAAATTGCAAAAAAAGTCATCGATGCCTTGGGCGGACGTGAAAATGTC
    AATAGTGTTGCCCACTGTGCGACTCGTCTACGTGTCATGGTCAAAGATGAAGAGAAAATC
    AATAAAGAAGTGATTGAGAACTTGGAAAAAGTTCAAGGTGCTTTCTTTAACTCAGGGCAA
    TACCAAATTATCTTTGGTACAGGTACAGTTAACAAAATGTACGATGAAGTTGTTGTACTT
    GGCTTACCAACATCATCTAAGGATGACATGAAAGCAGAAGTTGCTAAACAAGGGAACTGG
    TTCCAACGTGCTATCCGTACTTTCGGTGATGTTTTCGTTCCAATCATCCCAGTTATCGTA
    GCGACAGGTCTCTTCATGGGTGTGCGTGGTCTTTTCAACGCTCTTGAAATGCCACTTCCA
    GGTGACTTTGCAACTTACACACAAATCTTGACAGATACAGCCTTCATCATCTTGCCAGGT
    TTGGTTGTGTGGTCAACCTTCCGTGTATTTGGTGGAAATCCTGCCGTTGGTATCGTTCTT
    GGTATGATGCTTGTCTCTGGCTCACTTCCAAACGCTTGGGCAGTTGCTCAAGGTGGTGAA
    GTAACAGCGATGAACTTCTTTGGTTTCATCCCTGTTGTTGGTTTGCAAGGTTCCGTTCTT
    CCAGCCTTCATCATCGGGGTTGTCGGAGCTAAATTTGAAAAAGCTGTCCGCAAGGTTGTT
    CCAGATGTCATTGACCTCTTGGTAACACCATTCGTGACACTTTTGGTCATGTCTATCCTT
    GGACTCTTTGTCATTGGACCAGTTTTCCACGTTGTTGAAAACTACATCCTTATTGCTACA
    AAAGCGATTCTTAGCATGCCATTTGGTCTTGGTGGTTTCTTGATTGGTGGGGTTCACCAA
    TTGATCGTCGTGTCAGGTGTGCACCACATCTTCAACTTGCTTGAAGTGCAATTACTTGCT
    GCTGACCATGCTAACCCATTCAACGCTATCATCACAGCTGCTATGACAGCTCAAGGTGCT
    GCTACTGTTGCGGTTGGTGTTAAAACAAAAAATCCAAAACTGAAAACACTTGCTTTCCCG
    GCTGCTCTTTCTGCCTTCCTAGGTATTACAGAGCCTGCTATCTTCGGGGTGAACTTGCGC
    TTCCGTAAACCATTCTTCCTTTCATTGATTGCTGGTGCAATCGGTGGTGGATTGGCTTCT
    ATCCTTGGACTTGCTGGTACTGGTAATGGTATCACCATCATCCCTGGTACAATGCTTTAT
    GTTGGTAACGGACAACTTCCACAATACCTTCTTATGGTAGCTGTATCATTTGCCCTTGGT
    TTTGCTCTTACTTACATGTTTGGTTACGAAGATGAAGTAGACGCAACTGCAGCTGCAAAA
    CAAGCTGAAGTGGCTGAAGAAAAAGAAGAAGTTGCGCCAGCAGCTCTTCAAAATGAAACA
    CTTGTAACTCCTATCGTCGGTGATGTTGTCGCTCTTGCTGATGTCAATGACCCAGTCTTC
    TCAAGTGGAGCTATGGGACAAGGTATCGCTGTGAAACCAAGTCAAGGCGTGGTCTATGCA
    CTAGCTGATGCTGAAGTTTCAATTGCCTTTCCAACAGGGCACGCTTTTGGTTTGAAAACA
    AGAAATGGTGCTGAAGTTTTGATTCACGTTGGTATTGACACTGTATCTATGAACGGTGAC
    GGTTTTGAAGCAAAAGTTGCTCAAGGTAATAAGGTGAAAGCTGGCGATGTTCTTGGAACA
    TTTGACTCAAACAAAATCGCTGCAGCTGGACTTGATGATACAACAATGGTTATCGTTACA
    AATACAGCTGACTACGCTTCAGTAGCTCCAGTCGCAACAGGTTCAGTTTCGAAGGGGGAT
    GCTGTGATCGAAGTGAAAATCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1884

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1566 [new locus tag: SPR_RS07775 ]
  • symbol: ScrA
  • description: Phosphotransferase system enzyme II
  • length: 627
  • theoretical pI: 5.06389
  • theoretical MW: 65643.1
  • GRAVY: 0.570175

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.7.1.69?  ExPASy
    Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208
  • ⊞TIGRFAM:
    PTS system, sucrose-specific IIBC component (TIGR01996; EC 2.7.1.69; HMM-score: 561.4)
    PTS system, beta-glucoside-specific IIABC component (TIGR01995; EC 2.7.1.69; HMM-score: 491)
    and 12 more
    PTS system, trehalose-specific IIBC component (TIGR01992; EC 2.7.1.69; HMM-score: 331.6)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, maltose and glucose-specific subfamily, IIC component (TIGR00852; HMM-score: 156.5)
    Signal transduction Signal transduction PTS PTS system, maltose and glucose-specific subfamily, IIC component (TIGR00852; HMM-score: 156.5)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose subfamily, IIA component (TIGR00830; HMM-score: 140.8)
    Signal transduction Signal transduction PTS PTS system, glucose subfamily, IIA component (TIGR00830; HMM-score: 140.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose-like IIB component (TIGR00826; EC 2.7.1.69; HMM-score: 71.1)
    Signal transduction Signal transduction PTS PTS system, glucose-like IIB component (TIGR00826; EC 2.7.1.69; HMM-score: 71.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, N-acetylglucosamine-specific IIBC component (TIGR01998; EC 2.7.1.69; HMM-score: 38.6)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, alpha-glucoside-specific IIBC component (TIGR02005; EC 2.7.1.69; HMM-score: 38.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose-specific IIBC component (TIGR02002; EC 2.7.1.69; HMM-score: 36.5)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, maltose and glucose-specific IIBC component (TIGR02004; EC 2.7.1.69; HMM-score: 29.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, IIBC component (TIGR02003; EC 2.7.1.69; HMM-score: 27.6)
  • ⊞TheSEED  :
    • PTS system, sucrose-specific IIA component (EC 2.7.1.211)
    • PTS system, sucrose-specific IIB component (EC 2.7.1.211)
    • PTS system, sucrose-specific IIC component
    Carbohydrates Di- and oligosaccharides Sucrose utilization  PTS system, sucrose-specific IIA component (EC 2.7.1.69)
    and 2 more
    Carbohydrates Di- and oligosaccharides Sucrose utilization  PTS system, sucrose-specific IIB component (EC 2.7.1.69)
    Carbohydrates Di- and oligosaccharides Sucrose utilization  PTS system, sucrose-specific IIC component (EC 2.7.1.69)
  • ⊞PFAM:
    Hybrid (CL0105) PTS_EIIA_1; phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PF00358; HMM-score: 158.3)
    and 5 more
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 119.7)
    no clan defined PTS_EIIB; phosphotransferase system, EIIB (PF00367; HMM-score: 59.1)
    Hybrid (CL0105) Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 16.3)
    Peptidase_M23; Peptidase family M23 (PF01551; HMM-score: 15.5)
    no clan defined LapA_dom; Lipopolysaccharide assembly protein A domain (PF06305; HMM-score: 9.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011166
    • TAT(Tat/SPI): 0.000631
    • LIPO(Sec/SPII): 0.001783
  • predicted transmembrane helices (TMHMM): 10

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEEKINKEVIENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEVAKQGNWFQRAIRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPGLVVWSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGSVLPAFIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYILIATKAILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAAMTAQGAATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAGAIGGGLASILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYEDEVDATAAAKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQGIAVKPSQGVVYALADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKVAQGNKVKAGDVLGTFDSNKIAAAGLDDTTMVIVTNTADYASVAPVATGSVSKGDAVIEVKI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞regulators: CcpA regulon, ScrR (repression) regulon

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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