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HU-OH
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Hu17
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INV200
serotype 14
JJA
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MDRSPN001
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NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
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P1031
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R6
serotype 2
SP49
serotype 19A
SPN032672
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SPN034156
serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
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SPNA45
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ST556
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0961 [new locus tag: SPR_RS04810 ]
  • pan locus tag?: PNEUPAN002189000
  • symbol: rffD
  • pan gene symbol?: rffD
  • synonym:
  • product: UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0961 [new locus tag: SPR_RS04810 ]
  • symbol: rffD
  • product: UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 941893..943188
  • length: 1296
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAAAAATAATTTCCTAAGTAGAATTCAAAATAAGAAGGCAAATATTACAATTTGGGGT
    GCAGGATATATAGGTCTATCTACAGCTTACCACTTTGCATTGGTAGGTTTCCGCGTCAAA
    ATTTTTGATACTAATCATAGATTGATACAGAATTTACTTGAAGGAAATCTGCCATTTAAA
    ATTGATTTAGATGAAGAAATATTTAGTAAGTTAATATTTAATAAATCCATTTTACCAGAA
    GTTGTAGAACATGCTGATACATATTCTGATGAGATACAAATTATCTGTATTAATACTGAA
    AGAAATGGAGTACCTATTAGTAGACCATTAACTACTGTATTAGATAATATAACAACAGTA
    TCTGAACAACTAGTTATTGTTGAAAGTACAATTTCTCCAAATTGGATTGATACAATTATA
    AGACCAAAGTTGAATGATTTGCAATATCTAACAGTTGCTCCTAGGAGAGACTGGTTTTTA
    GAGACTGGATTAAATTTAAAAACACTTCCTCGAGTTATTGGTACATTGGGATCAAATTAT
    CGTATGGAGGTTTTGAAATTATATGAAATGCTTTCTGATGTTGTGATTGAGGTAACTGAT
    GCATATCACGCTTGTTTAGTAAAGGCGGTTGAAAATTCTATACGCTATATTAATGTTGTA
    TTTGCTAATGAAATGATGAGAGCATTTCCAAGATATAATATGGCTGAAATTTTTGATGCT
    GCTTCAACTAAGTGGAATATTCCTTATTATCATCCGTCAATTGGAATTGGAGGGTACTGT
    CTTCCGTTAGCTCCTAAATATATTTTGGATGCAGTCAATGATAGTGAGGAGTTACCTATG
    CTGAGGGAGTCAGTTAAATCTGATTTAAAGCAGTCTGACTTTATTACTGACTTAATCAAA
    AGCTATAACTGTCAAAAAGTAGGAGTATTAGGTCTAAGTTATGCTCCGGAGACTAAAATT
    TGGAAGAATTCCCCAGTTGTTAGTTTAATCTATTCTTTGTTAAGAAATGGAATAGAAGTG
    AAAATAAATGATCCATATTTCTCTAGTGAAGAAATTCAAGAAATAACGACTGTTCAATCT
    TTCAGTTTAAATAGTGAGTCACTACAAGAATTTGATATACTGGTAATTGCTACCTCACAT
    AAAAGCTATGATGGAGAATTGGAGAGAATACTTTTTGATTTAAATAAAGAAATGATTATT
    TTTGATAATTTTGGAGTGAATAAGAATCTATCTAAATTACCAAATATTCATTATTTTGAA
    ATTGGGAACTTCCAATATAATGAAAGTAGGAGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1296

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0961 [new locus tag: SPR_RS04810 ]
  • symbol: RffD
  • description: UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase
  • length: 431
  • theoretical pI: 5.08779
  • theoretical MW: 49386.3
  • GRAVY: -0.0832947

⊟Function[edit | edit source]

  • TIGRFAM:
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 194.5)
    and 9 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 15.8)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 14.3)
    Genetic information processing Protein fate Protein folding and stabilization xanthine dehydrogenase accessory protein XdhC (TIGR02964; HMM-score: 14.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Other xanthine dehydrogenase accessory protein XdhC (TIGR02964; HMM-score: 14.2)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 14.1)
    Metabolism Amino acid biosynthesis Other pyrrolysine biosynthesis protein PylD (TIGR03911; HMM-score: 13.3)
    glutamate synthase, small subunit (TIGR01318; HMM-score: 12.8)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 10.4)
    Metabolism Amino acid biosynthesis Glutamate family glutamate synthase (NADPH), homotetrameric (TIGR01316; EC 1.4.1.13; HMM-score: 10.2)
  • TheSEED  :
    • UDP-N-acetyl-D-mannosamine dehydrogenase (EC 1.1.1.336)
  • PFAM:
    HUP (CL0039) UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain (PF03720; HMM-score: 57.1)
    and 11 more
    NADP_Rossmann (CL0063) UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 42.9)
    6PGD_C (CL0106) UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain (PF00984; HMM-score: 40.4)
    NADP_Rossmann (CL0063) 3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 18.6)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 17.3)
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 17)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 16.7)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 16.2)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 15.7)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 14.9)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 13.2)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9222
    • Cytoplasmic Membrane Score: 0.044
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0334
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010653
    • TAT(Tat/SPI): 0.000833
    • LIPO(Sec/SPII): 0.002224
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKNNFLSRIQNKKANITIWGAGYIGLSTAYHFALVGFRVKIFDTNHRLIQNLLEGNLPFKIDLDEEIFSKLIFNKSILPEVVEHADTYSDEIQIICINTERNGVPISRPLTTVLDNITTVSEQLVIVESTISPNWIDTIIRPKLNDLQYLTVAPRRDWFLETGLNLKTLPRVIGTLGSNYRMEVLKLYEMLSDVVIEVTDAYHACLVKAVENSIRYINVVFANEMMRAFPRYNMAEIFDAASTKWNIPYYHPSIGIGGYCLPLAPKYILDAVNDSEELPMLRESVKSDLKQSDFITDLIKSYNCQKVGVLGLSYAPETKIWKNSPVVSLIYSLLRNGIEVKINDPYFSSEEIQEITTVQSFSLNSESLQEFDILVIATSHKSYDGELERILFDLNKEMIIFDNFGVNKNLSKLPNIHYFEIGNFQYNESRR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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