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serotype 4
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serotype 2
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serotype 19A
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serotype 19F
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serotype 6B
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serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
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ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1067 [new locus tag: SPR_RS05330 ]
  • pan locus tag?: PNEUPAN002447000
  • symbol: lacR
  • pan gene symbol?: lacR
  • synonym:
  • product: Lactose phosphotransferase system repressor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1067 [new locus tag: SPR_RS05330 ]
  • symbol: lacR
  • product: Lactose phosphotransferase system repressor
  • replicon: chromosome
  • strand: +
  • coordinates: 1065778..1066539
  • length: 762
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGCTCAAACAAGAAAAATTAGCCAAAATTTTAGAGATAGTAAATAGTAAAGGAACCATA
    ACAGTTAAACAGATTATGGACGAAATAGCCGTTTCAGATATGACTGCAAGGCGCTATTTA
    CAGGAATTAGCTGATAAAGATTTGCTGATTCGTGTGCATGGTGGAGCTGAAAAACTTCGA
    ACCAACTCCCTTTTGACTAATGAGCGATCAAATATTGAAAAACAAGCCCTCCAAACGGCA
    GAAAAACAAGAAATAGCCCATTTTGCAGGCAGTCTAGTAGAAGAAAGAGAAACTATTTTC
    ATTGGACCAGGAACAACATTAGAGTTTTTTGCGCGTGAGTTGCCTATTGACAATATCCGC
    GTCGTAACCAACAGTCTACCTGTTTTTCTGATTTTAAGCGAACGAAAATTAACAGATTTG
    ATTTTGATAGGTGGAAATTATCGCGATATTACAGGTGCTTTTGTTGGCACATTGACCCTA
    CAAAATCTCTCTAATCTCCAATTTTCTAAAGCTTTCGTTAGCTGTAATGGTATTCAAAAC
    GGAGCTCTAGCTACTTTTAGCGAGGAAGAGGGAGAGGCTCAACGCATCGCTTTAAATAAT
    TCTAATAAAAAATATTTACTCGCAGATCATAGTAAGTTCAATAAGTTTGATTTTTATACT
    TTTTATAATATATCAAATCTTGATACTATTGTTTCAGATTCTAAACTAAGTGATTCAATC
    CTTTTTAAGCTATCTAAACACATTAAAGTCATCAAGCCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    762

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1067 [new locus tag: SPR_RS05330 ]
  • symbol: LacR
  • description: Lactose phosphotransferase system repressor
  • length: 253
  • theoretical pI: 7.66375
  • theoretical MW: 28401.4
  • GRAVY: -0.13834

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 21.3)
    and 5 more
    Metabolism Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 16)
    Signal transduction Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 16)
    Signal transduction Regulatory functions DNA interactions staphylococcal accessory regulator family (TIGR01889; HMM-score: 14.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 12.1)
    Signal transduction Regulatory functions DNA interactions iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 12.1)
  • TheSEED  :
    • Lactose phosphotransferase system repressor
    Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  Lactose phosphotransferase system repressor
  • PFAM:
    ISOCOT_Fold (CL0246) DeoRC; DeoR C terminal sensor domain (PF00455; HMM-score: 165.1)
    and 17 more
    HTH (CL0123) HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 57.1)
    HTH_11; HTH domain (PF08279; HMM-score: 29.9)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 23.9)
    GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 22.8)
    FaeA; FaeA-like protein (PF04703; HMM-score: 18.2)
    MarR; MarR family (PF01047; HMM-score: 16.1)
    Ribosomal_S25; S25 ribosomal protein (PF03297; HMM-score: 16.1)
    HTH_45; Winged helix-turn-helix (PF14947; HMM-score: 14.9)
    DUF977; Bacterial protein of unknown function (DUF977) (PF06163; HMM-score: 14.6)
    no clan defined ANT; Phage antirepressor protein KilAC domain (PF03374; HMM-score: 14.2)
    HTH (CL0123) HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 14.1)
    HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 14)
    Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 13.8)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 13.5)
    Penicillinase_R; Penicillinase repressor (PF03965; HMM-score: 12.8)
    HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 12.4)
    MarR_2; MarR family (PF12802; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effector: D-galactose-6-phosphate
  • genes regulated by LacR, TF important in Lactose utilization, Galactose utilizationRegPrecise
    repression
    lacD < lacC < lacB < lacA
    spr1081
    transcription units transferred from TIGR4 data RegPrecise

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00125
    • TAT(Tat/SPI): 0.000101
    • LIPO(Sec/SPII): 0.000194
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLKQEKLAKILEIVNSKGTITVKQIMDEIAVSDMTARRYLQELADKDLLIRVHGGAEKLRTNSLLTNERSNIEKQALQTAEKQEIAHFAGSLVEERETIFIGPGTTLEFFARELPIDNIRVVTNSLPVFLILSERKLTDLILIGGNYRDITGAFVGTLTLQNLSNLQFSKAFVSCNGIQNGALATFSEEEGEAQRIALNNSNKKYLLADHSKFNKFDFYTFYNISNLDTIVSDSKLSDSILFKLSKHIKVIKP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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