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NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1229 [new locus tag: SPR_RS06145 ]
  • pan locus tag?: PNEUPAN002647000
  • symbol: aroA
  • pan gene symbol?: aroA
  • synonym:
  • product: 3-Enolpyruvylshikimate-5-phosphate synthetase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1229 [new locus tag: SPR_RS06145 ]
  • symbol: aroA
  • product: 3-Enolpyruvylshikimate-5-phosphate synthetase
  • replicon: chromosome
  • strand: -
  • coordinates: 1226334..1227629
  • length: 1296
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAGGTCCAGTATGAAACTAAAAACAAACATTCGCCATTTACATGGTAGTATCCGCGTC
    CCAGGTGACAAGTCTATCAGCCACCGTTCCATTATCTTTGGAAGTTTGGCTGAGGGTGAG
    ACCAAGGTTTATGATATTCTGCGAGGTGAAGACGTTCTTTCGACCATGCAGGTTTTTCGT
    GACCTTGGTGTTGAAATTGAGGATAAAGATGGGGTTATTACCATTCAAGGTGTAGGCATG
    GCTGGCTTAAAAGCGCCACAAAATGCCCTTAATATGGGAAATTCTGGCACCTCGATTCGC
    CTGATTTCAGGTGTCCTTGCTGGTGCAGATTTCGAAGTAGAGATGTTTGGAGATGATAGT
    CTTTCCAAACGTCCTATGGACCGTGTGACCCTTCCACTGAAAAAAATGGGCGTCAGCATT
    TCAGGGCAAACTGAACGAGACTTGCCTCCCCTTCGCTTAAAAGGGACGAAAAACCTAAGA
    CCTATTCATTATGAGTTGCCAATTGCCTCTGCCCAAGTCAAGTCAGCCTTGATGTTTGCA
    GCCTTACAAGCTAAGGGGGAGTCAGTTATTATCGAAAAAGAGTGCACCCGTAATCATACT
    GAAGATATGTTGAAACAATTTGGTGGTCATTTAAGTGTGGACGGTAAGAAAATCACAGTC
    CAAGGGCCACAAAAATTGACAGGACAGAAGGTGGTCGTACCAGGAGATATTTCCAGTGCA
    GCCTTTTGGTTAGTCGCAGGTTTGATTAATCCAAATTCTCATCTAGTGCTGCAGAATGTG
    GGAATCAACGAAACGCGTACTGGTATTATTGATGTCATTCGTGCCATGGGTGGAAAATTA
    GAAGTTACTGAAATCGATCCAGTCGCTAAATCTTCTACCTTGACTGTTGAGTCTTCTGAC
    TTGAAAGGAACAGAAATTGGTGGCGCTTTGATTCCACGATTGATTGATGAATTGCCCATT
    ATTGCCCTACTTGCGACCCAAGCCCAAGGTGTAACAGTTATCAAGGATGCTGAGGAGCTC
    AAGGTCAAGGAAACAGACCGTATTCAGGTTGTGGCAGACGCCTTAAATAGTATGGGAGCA
    GATATTACTCCTACGGCAGATGGGATGATTATCAAAGGAAAATCAGCTCTTCACGGTGCT
    AGAGTCAATACGTTTGGTGACCACCGTATCGGCATGATGACAGCTATCGCAGCCCTCTTG
    GTTGCAGATGGAGAGGTGGAGCTTGACCGTGCAGAAGCCATCAATACCAGCTATCCTAGT
    TTCTTTGATGATTTGGAGAGCTTGATTCATGGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1296

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1229 [new locus tag: SPR_RS06145 ]
  • symbol: AroA
  • description: 3-Enolpyruvylshikimate-5-phosphate synthetase
  • length: 431
  • theoretical pI: 6.19972
  • theoretical MW: 46181
  • GRAVY: -0.0180974

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.19?  ExPASy
    3-phosphoshikimate 1-carboxyvinyltransferase Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family 3-phosphoshikimate 1-carboxyvinyltransferase (TIGR01356; EC 2.5.1.19; HMM-score: 462)
    and 1 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine 1-carboxyvinyltransferase (TIGR01072; EC 2.5.1.7; HMM-score: 121.4)
  • TheSEED  :
    • 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) alpha sub-homology division
    Amino Acids and Derivatives Aromatic amino acids and derivatives Chorismate Synthesis  5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)
    and 1 more
    Amino Acids and Derivatives Aromatic amino acids and derivatives Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate)  5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)
  • PFAM:
    EPT_RTPC (CL0290) EPSP_synthase; EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (PF00275; HMM-score: 399)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9923
    • Cytoplasmic Membrane Score: 0.0008
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0067
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004342
    • TAT(Tat/SPI): 0.000448
    • LIPO(Sec/SPII): 0.000951
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRSSMKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLSTMQVFRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNMGNSGTSIRLISGVLAGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHYELPIASAQVKSALMFAALQAKGESVIIEKECTRNHTEDMLKQFGGHLSVDGKKITVQGPQKLTGQKVVVPGDISSAAFWLVAGLINPNSHLVLQNVGINETRTGIIDVIRAMGGKLEVTEIDPVAKSSTLTVESSDLKGTEIGGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADALNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADGEVELDRAEAINTSYPSFFDDLESLIHG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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