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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1487 [new locus tag: SPR_RS07390 ]
  • pan locus tag?: PNEUPAN003058000
  • symbol: relA
  • pan gene symbol?: relA
  • synonym:
  • product: GTP pyrophosphokinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1487 [new locus tag: SPR_RS07390 ]
  • symbol: relA
  • product: GTP pyrophosphokinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1462935..1465157
  • length: 2223
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    ATGCCGAAAGAAGTGAATTTAACAGGCGAAGAAGTTGTCGCTTTAACCAAAGAATATTTA
    ACGGAAGAGGATGTTCATTTTGTCCATAAGGCCTTGGTCTATGCTGTTGAATGCCACAGT
    GGTCAATATCGCAAATCAGGCGAGCCTTATATCATTCACCCTATCCAAGTGGCAGGTATT
    TTAGCTAAGCTAAAGCTGGATGCTGTAACAGTAGCTTGTGGATTCTTGCATGATGTGGTG
    GAAGATACAGATGCGACTTTGGACGATTTGGAAAGAGAGTTTGGTCCTGATGTGCGGATG
    ATTGTTGACGGAGTTACCAAGCTTGGCAAGGTCGAGTACAAATCGATCGAGGAGCAATTA
    GCGGAAAATCATCGCAAGATGCTCATGGCCATGTCTGAGGACATCCGCGTTATTTTGGTC
    AAACTGTCTGACCGCTTGCACAATATGCGGACCCTGAAACATCTTCGAAAAGACAAGCAG
    GAGCGTATTTCCAAAGAAACCATGGAAATCTATGCCCCGCTTGCCCATCGTTTGGGGATT
    TCCAGTGTCAAATGGGAATTAGAAGACTTGTCTTTCCGTTATCTCAATCCAACGGAGTTT
    TACAAGATTACCCATATGATGAAGGAAAAGCGCAGGGAGCGTGAGGCCTTGGTGGATGAG
    GTAGTCACAAAATTAGAGGAGTATACGACAGAACGTCACTTGAAAGGGAAGATTTATGGT
    CGTCCCAAGCATATTTACTCAATTTTCCGCAAAATGCAGGACAAGAGAAAACGGTTTGAG
    GAAATCTATGATCTGATTGCTATTCGTTGTATTTTAGATACCCAAAGTGATGTTTATGCC
    ATGCTTGGTTACGTGCATGAATTTTGGAAACCGATGCCAGGTCGCTTCAAAGACTATATC
    GCCAACCGCAAGGCCAATGGTTATCAGTCTATCCATACGACTGTTTATGGACCAAAAGGG
    CCGATTGAATTCCAGATTCGAACCAAGGAAATGCACGAGGTGGCTGAGTACGGGGTTGCG
    GCTCACTGGGCTTATAAGAAAGGTATAAAGGGGCAAGTTAACAGCAAGGAATCAGCTATT
    GGAATGAACTGGATCAAGGAGATGATGGAGCTCCAAGACCAGGCTGATGATGCTAAGGAA
    TTTGTGGACTCTGTTAAGGAAAACTATTTGGCTGAGGAGATTTACGTTTTTACCCCAGAT
    GGAGCTGTCCGTTCCCTTCCCAAAGATTCAGGACCGATTGATTTTGCCTACGAAATCCAT
    ACCAAGGTCGGTGAAAAAGCAACTGGTGCCAAGGTCAATGGCCGCATGGTTCCACTGACA
    ACCAAGTTAAAGACAGGGGATCAGGTTGAAATTATCGCCAACCCGAACTCCTTTGGACCT
    AGCCGTGACTGGCTCAATATGGTCAAGACTAGCAAGGCGCGCAATAAGATTCGCCAGTTC
    TTTAAAAACCAAGATAAGGAATTGTCTGTCAACAAGGGTCGTGAGATGCTGATGGCTCAG
    TTCCAAGAAAATGGCTATGTGGCAAATAAATTTATGGACAAGCGCCACATGGATCAAGTT
    CTGCAAAAGACCAGTTACAAGACAGAAGACTCCCTCTTTGCGGCCATTGGTTTTGGGGAA
    ATCGGTGCGATTACCGTCTTTAACCGTCTGACTGAAAAGGAGCGCCGTGAGGAAGAGCGT
    GCCAAGGCCAAGGCTGAGGCAGAGGAGCTTGTCAAAGGTGGCGAGGTCAAGGTTGAAAAT
    AAAGAAACTCTCAAGGTCAAGCATGAGGGGGGAGTGGTTATTGAAGGTGCTTCTGGTCTC
    CTAGTGCGGATTGCTAAGTGTTGTAACCCCGTGCCTGGTGACGATATTGTTGGCTACATT
    ACCAAGGGTCGTGGTGTGGCTATTCACCGTGTGGACTGTATGAACCTGCGTGCCCAAGAA
    AACTACGAGCAACGTCTCCTTGATGTGGAATGGGAAGACCAGTACTCTAGCTCAAATAAG
    GAGTATATGGCCCATATCGATATCTACGGTCTCAACCGTACAGGACTGTTGAACGATGTA
    CTGCAAGTTCTTTCAAATACAACCAAGAATATTTCAACGGTCAATGCCCAACCAACCAAG
    GATATGAAGTTTGCTAATATCCATGTGTCCTTCGGTATTGCCAACCTCTCTACACTGACC
    ACGGTTGTCGATAAAATTAAGAGTGTGCCAGAAGTTTACTCTGTCAAACGGACCAACGGC
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2223

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1487 [new locus tag: SPR_RS07390 ]
  • symbol: RelA
  • description: GTP pyrophosphokinase
  • length: 740
  • theoretical pI: 7.94081
  • theoretical MW: 84645.5
  • GRAVY: -0.510405

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.6.5?  ExPASy
    GTP diphosphokinase ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate
  • TIGRFAM:
    Cellular processes Cellular processes Adaptations to atypical conditions RelA/SpoT family protein (TIGR00691; HMM-score: 787.7)
  • TheSEED  :
    • GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II
    • Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)
    Regulation and Cell signaling Regulation and Cell signaling - no subcategory Stringent Response, (p)ppGpp metabolism  GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I
    and 1 more
    Regulation and Cell signaling Signal transduction in Eukaryotes Plastidial (p)ppGpp-mediated response in plants  GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I
  • PFAM:
    HD_PDEase (CL0237) HD_4; HD domain (PF13328; HMM-score: 161.9)
    and 7 more
    NTP_transf (CL0260) RelA_SpoT; Region found in RelA / SpoT proteins (PF04607; HMM-score: 122.7)
    ACT (CL0070) ACT_4; ACT domain (PF13291; HMM-score: 72.3)
    Ubiquitin (CL0072) TGS; TGS domain (PF02824; HMM-score: 69.2)
    no clan defined RelA_AH_RIS; RelA/SpoT, AH and RIS domains (PF19296; HMM-score: 68.7)
    HD_PDEase (CL0237) HD; HD domain (PF01966; HMM-score: 38.1)
    Ubiquitin (CL0072) ThiS; ThiS family (PF02597; HMM-score: 17.2)
    no clan defined Fibritin_C; Fibritin C-terminal region (PF07921; HMM-score: 13.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.836
    • Cytoplasmic Membrane Score: 0.0265
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.1371
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00526
    • TAT(Tat/SPI): 0.000366
    • LIPO(Sec/SPII): 0.00047
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRMIVDGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLEEYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAEEIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVEIIANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Krystyna M Kazmierczak, Kyle J Wayne, Andreas Rechtsteiner, Malcolm E Winkler
Roles of rel(Spn) in stringent response, global regulation and virulence of serotype 2 Streptococcus pneumoniae D39.
Mol Microbiol: 2009, 72(3);590-611
[PubMed:19426208] [WorldCat.org] [DOI] (I p)

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