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serotype 4
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serotype 6B
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70585
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serotype 23F
BVJ1JL
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CGSP14
serotype 14
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Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
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R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1846 [new locus tag: SPR_RS09345 ]
  • pan locus tag?: PNEUPAN003622000
  • symbol: sgh
  • pan gene symbol?: ulaD
  • synonym:
  • product: Hexulose-6-phosphate synthase (HumpS)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1846 [new locus tag: SPR_RS09345 ]
  • symbol: sgh
  • product: Hexulose-6-phosphate synthase (HumpS)
  • replicon: chromosome
  • strand: -
  • coordinates: 1822669..1823403
  • length: 735
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    TTGAAGAATCTAAGGATAGCCCTTATCTCGAAGGATTGGATTTGGAAAGTTAGAAAGAGG
    AATAAAGAAATGACAAAAAGAATACCTAATTTACAAGTTGCATTAGACCATTCAGACTTG
    CAAGGAGCGATTAAAGCAGCTGTTTCTGTTGGTCAGGAAGTAGATATTATCGAAGCTGGA
    ACTGTTTGCTTGCTTCAAGTTGGAAGTGAACTGGCTGAAGTCTTGCGTAGCCTTTTCCCA
    GATAAGATTATTGTGGCAGACACAAAATGTGCTGATGCTGGTGGAACAGTTGCTAAAAAT
    AATGCGGTTCGTGGAGCAGACTGGATGACTTGTATCTGTTGTGCAACCATCCCTACTATG
    GAAGCAGCTCTAAAGGCTATCAAGACTGAACGAGGAGAACGAGGCGAAATCCAGATCGAG
    CTTTATGGCGATTGGACTTTTGAACAAGCTCAGCTTTGGCTAGATGCAGGTATTTCACAA
    GCTATTTATCACCAATCTCGTGATGCTCTTCTTGCTGGTGAAACTTGGGGTGAAAAAGAC
    CTTAATAAGGTTAAAAAACTCATTGACATGGGCTTCCGTGTATCTGTAACAGGTGGTCTA
    GATGTAGATACTCTCAAACTCTTTGAAGGTGTTGATGTCTTTACCTTTATCGCAGGTCGT
    GGAATTACAGAGGCTGCGGATCCAGCAGGAGCAGCGCGTGCCTTCAAGGATGAAATCAAA
    CGAATTTGGGGGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    735

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1846 [new locus tag: SPR_RS09345 ]
  • symbol: Sgh
  • description: Hexulose-6-phosphate synthase (HumpS)
  • length: 244
  • theoretical pI: 5.90937
  • theoretical MW: 26762.7
  • GRAVY: -0.0446721

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.2.-?  ExPASy
  • TIGRFAM:
    3-hexulose-6-phosphate synthase (TIGR03128; EC 4.1.2.43; HMM-score: 102.7)
    and 2 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotidine 5'-phosphate decarboxylase (TIGR01740; EC 4.1.1.23; HMM-score: 36.2)
    Metabolism Energy metabolism Electron transport NADH-quinone oxidoreductase, B subunit (TIGR01957; HMM-score: 12.7)
  • TheSEED  :
    • 3-keto-L-gulonate-6-phosphate decarboxylase (EC 4.1.1.85)
    • 3-keto-L-gulonate-6-phosphate decarboxylase UlaD (EC 4.1.1.85)
    Carbohydrates Monosaccharides L-ascorbate utilization (and related gene clusters)  3-keto-L-gulonate 6-phosphate decarboxylase
  • PFAM:
    TIM_barrel (CL0036) OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family (PF00215; HMM-score: 93.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009358
    • TAT(Tat/SPI): 0.000261
    • LIPO(Sec/SPII): 0.000633
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKNLRIALISKDWIWKVRKRNKEMTKRIPNLQVALDHSDLQGAIKAAVSVGQEVDIIEAGTVCLLQVGSELAEVLRSLFPDKIIVADTKCADAGGTVAKNNAVRGADWMTCICCATIPTMEAALKAIKTERGERGEIQIELYGDWTFEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNKVKKLIDMGFRVSVTGGLDVDTLKLFEGVDVFTFIAGRGITEAADPAGAARAFKDEIKRIWG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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