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NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1920 [new locus tag: SPR_RS09780 ]
  • pan locus tag?: PNEUPAN003712000
  • symbol: malD
  • pan gene symbol?: malD
  • synonym:
  • product: ABC transporter membrane-spanning permease - maltose/maltodextrin

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1920 [new locus tag: SPR_RS09780 ]
  • symbol: malD
  • product: ABC transporter membrane-spanning permease - maltose/maltodextrin
  • replicon: chromosome
  • strand: +
  • coordinates: 1902742..1903605
  • length: 864
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    TTGATATGGAGGACGTCTAAGATGAATAACTCAATTAAACTCAAACGTAGACTGACTCAA
    AGCCTTACTTACCTTTACCTGATTGGTCTATCAATTGTAATTATCTATCCACTGTTGATT
    ACCATTATGTCAGCCTTTAAAGCAGGTAACGTCTCAGCCTTTAAACTAGATACTAATATC
    GACCTCAATTTTGATAACTTTAAAGGCCTCTTCACTGAAACCTTGTACGGTACTTGGTAC
    CTCAACACTTTGATTATCGCCTTAATTACCATGGCTGTTCAAACAAGTATCATCGTACTT
    GCTGGTTATGCTTACAGCCGTTACAACTTCTTGGCTCGTAAACAAAGTTTGGTCTTCTTC
    TTGATCATCCAAATGGTGCCAACTATGGCCGCTTTGACAGCCTTCTTCGTTATGGCGCTT
    ATGTTGAACGCCCTTAACCACAACTGGTTCCTCATCTTCCTCTACGTTGGTGGTGGTATC
    CCGATGAATGCTTGGCTCATGAAAGGCTACTTCGATACAGTGCCAATGTCTTTAGACGAA
    TCTGCAAAACTAGACGGTGCAGGACACTTCCGCCGCTTCTGGCAAATTGTTCTACCACTT
    GTTCGCCCAATGGTTGCCGTACAAGCTCTCTGGGCCTTCATGGGACCTTTCGGGGACTAC
    ATCCTCTCTAGTTTCTTGCTTCGTGAGAAAGAATACTTTACTGTTGCCGTAGGTCTCCAA
    ACCTTCGTTAACAATGCGAAAAACTTGAAGATTGCCTACTTCTCAGCAGGTGCTATCCTC
    ATCGCCCTTCCAATCTGTATTCTCTTCTTCTTCCTACAAAAGAACTTTGTTTCAGGACTT
    ACAAGTGGTGGCGACAAGGGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    864

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1920 [new locus tag: SPR_RS09780 ]
  • symbol: MalD
  • description: ABC transporter membrane-spanning permease - maltose/maltodextrin
  • length: 287
  • theoretical pI: 10.1156
  • theoretical MW: 32410.4
  • GRAVY: 0.651568

⊟Function[edit | edit source]

  • TIGRFAM:
    NifC-like ABC-type porter (TIGR01581; HMM-score: 23.7)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, permease protein (TIGR00969; HMM-score: 19.8)
    and 1 more
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, permease protein (TIGR02141; HMM-score: 14.5)
  • TheSEED  :
    • Maltodextrin ABC transporter, permease protein MdxG
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  Maltose/maltodextrin ABC transporter, permease protein MalG
  • PFAM:
    BPD_transp_1 (CL0404) BPD_transp_1; Binding-protein-dependent transport system inner membrane component (PF00528; HMM-score: 82.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.137106
    • TAT(Tat/SPI): 0.002439
    • LIPO(Sec/SPII): 0.004218
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIWRTSKMNNSIKLKRRLTQSLTYLYLIGLSIVIIYPLLITIMSAFKAGNVSAFKLDTNIDLNFDNFKGLFTETLYGTWYLNTLIIALITMAVQTSIIVLAGYAYSRYNFLARKQSLVFFLIIQMVPTMAALTAFFVMALMLNALNHNWFLIFLYVGGGIPMNAWLMKGYFDTVPMSLDESAKLDGAGHFRRFWQIVLPLVRPMVAVQALWAFMGPFGDYILSSFLLREKEYFTVAVGLQTFVNNAKNLKIAYFSAGAILIALPICILFFFLQKNFVSGLTSGGDKG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, MalR (repression) regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    MalR(TF)important in Maltose utilization, Maltodextrin utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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