From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1919 [new locus tag: SPR_RS09775 ]
  • pan locus tag?: PNEUPAN003713000
  • symbol: malC
  • pan gene symbol?: malC
  • synonym:
  • product: ABC transporter membrane-spanning permease - maltose/maltodextrin

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1919 [new locus tag: SPR_RS09775 ]
  • symbol: malC
  • product: ABC transporter membrane-spanning permease - maltose/maltodextrin
  • replicon: chromosome
  • strand: +
  • coordinates: 1901454..1902761
  • length: 1308
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAAAGGAGTTAATATGGAAAAGCAACAACCTAGTAAAGCAGCCCTGCTGTCTATCATT
    CCTGGGTTAGGACAGATTTACAATAAACAAAAAGCCAAAGGTTTTATCTTCCTTGGTGTA
    ACCATCGTATTTGTCCTTTACTTCCTAGCACTTGCAACCCCTGAATTGAGCAACCTCATC
    ACTCTTGGTGACAAACCAGGTCGTGATAATTCCCTCTTTATGCTGATTCGTGGTGCCTTC
    CATCTAATCTTTGTAATCGTTTATGTACTCTTTTATTTCTCAAATATCAAAGATGCACAT
    ACGATTGCAAAACGCATTAACAATGGAATTCCAGTTCCACGCACACTCAAAGACATGATC
    AAAGGGATTTATGAAAATGGCTTCCCTTACCTCTTGATCATTCCATCTTATGTTGCCATG
    ACCTTCGCGATTATCTTCCCAGTTATCGTAACCTTGATGATCGCCTTTACCAACTACGAC
    TTCCAACACTTGCCACCAAACAAGTTGTTGGACTGGGTTGGTTTGACCAACTTTACAAAC
    ATTTGGAGCTTGAGTACCTTCCGTTCTGCCTTTGGTTCTGTTCTTTCTTGGACTATCATT
    TGGGCTTTGGCAGCTTCTACTTTACAAATCGTAATTGGTATCTTCACAGCTATCATTGCC
    AACCAACCATTTATCAAAGGAAAACGTATCTTTGGTGTTATTTTCCTTCTTCCTTGGGCT
    GTCCCAGCCTTCATCACTATCTTGACATTCTCAAACATGTTTAACGATAGTGTCGGTGCT
    ATCAACACTCAAGTATTGCCAATCTTGGCTAAATTCCTTCCTTTCCTTGATGGAGCTCTT
    ATTCCTTGGAAAACAGACCCAACTTGGACTAAGATTGCCTTGATTATGATGCAAGGTTGG
    CTCGGATTCCCATACATCTACGTTTTGACTTTGGGTATCTTGCAATCTATTCCTAACGAC
    CTTTACGAAGCAGCTTATATTGACGGTGCCAACGCTTGGCAAAAATTCCGCAACATCACT
    TTCCCAATGATTTTGGCTGTTGCGGCACCTACTTTGATTAGCCAATACACCTTCAACTTT
    AACAACTTCTCTATCATGTACCTCTTCAATGGTGGAGGACCTGGTAGTGTCGGAGGTGGA
    GCTGGTTCAACCGATATCTTGATCTCATGGATCTACCGTTTGACAACAGGTACATCTCCT
    CAATACTCAATGGCGGCAGCTGTTACCTTGATTATCTCTATCATTGTCATCTCAATCTCT
    ATGATCGCATTCAAGAAACTACACGCATTTGATATGGAGGACGTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1308

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1919 [new locus tag: SPR_RS09775 ]
  • symbol: MalC
  • description: ABC transporter membrane-spanning permease - maltose/maltodextrin
  • length: 435
  • theoretical pI: 9.87011
  • theoretical MW: 48301.9
  • GRAVY: 0.655402

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, permease protein (TIGR03262; HMM-score: 35)
    NifC-like ABC-type porter (TIGR01581; HMM-score: 33.9)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, permease protein CysT (TIGR02139; HMM-score: 32.7)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, permease protein (TIGR00969; HMM-score: 31.8)
    and 3 more
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, permease protein (TIGR02141; HMM-score: 27.1)
    2-aminoethylphosphonate ABC transporter, permease protein (TIGR03226; HMM-score: 19.3)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, permease protein CysW (TIGR02140; HMM-score: 15.9)
  • TheSEED  :
    • Maltose/maltodextrin ABC transporter, permease protein MalF
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  Maltose/maltodextrin ABC transporter, permease protein MalF
  • PFAM:
    BPD_transp_1 (CL0404) BPD_transp_1; Binding-protein-dependent transport system inner membrane component (PF00528; HMM-score: 98.7)
    and 3 more
    no clan defined DUF5683; Family of unknown function (DUF5683) (PF18935; HMM-score: 27.4)
    DUF6677; Family of unknown function (DUF6677) (PF20382; HMM-score: 13.7)
    TM_PBP2_N; N-terminal of TM subunit in PBP-dependent ABC transporters (PF16296; HMM-score: 10.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 8
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.037377
    • TAT(Tat/SPI): 0.000479
    • LIPO(Sec/SPII): 0.006948
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKGVNMEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFLALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRINNGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLPPNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQPFIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALIPWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPNDLYEAAYIDGANAWQKFRNITFPMILAVAAPTLISQYTFNFNNFSIMYLFNGGGPGSVGGGAGSTDILISWIYRLTTGTSPQYSMAAAVTLIISIIVISISMIAFKKLHAFDMEDV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, MalR (repression) regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    MalR(TF)important in Maltose utilization, Maltodextrin utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=spr1919&oldid=130632"