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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS03145 [old locus tag: A66_00631 ]
  • pan locus tag?: PNEUPAN001607000
  • symbol: A66_RS03145
  • pan gene symbol?: moeB
  • synonym:
  • product: HesA/MoeB/ThiF family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS03145 [old locus tag: A66_00631 ]
  • symbol: A66_RS03145
  • product: HesA/MoeB/ThiF family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 612557..613639
  • length: 1083
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (612557..613639) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2205 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATACAGAATAAAACAGTATTAGTATTAGGAGCAGGAGCCTTAGGATGTTATATATCTTTA
    AGTCTAAGTATGTATGGAGTGAGGAAACTTATTGTCGCTGATTACGATATAATAGAACCA
    TCAAATTTAAATAGGCAAATTCTTTATACAGAGTCGGATGTTGGTAAGGAGAAGATTAAT
    GTTCTTTCTGAAAAAATACACAAGTATAATTCAGATGTTCAGGTAGTACCTATTTCTATT
    AAAGTTTCTTCATTAGAAGAATTAGAAAAAATTGTTGCGGAATATGGGAGTATAGATTTT
    ATCGTTAAAGCAATTGATACGCCCATTGATATTATAAAAATTGTCAATCAATTTGCTGTA
    TCGCATAAGATATCCTACATATCAGGAGGGTTTAATGGATGCTATCTTATTATTGATAAT
    ATATATATCCCTACCATCGGTTCTTGCTTTGGTTGTCGGAATATAAACAAAGATATAAAT
    AAGTACACTTTATCTGATAAGACAAAGTGGCCGACTACACCAGAGATGCCTGCTATTTTG
    GGAGGGATAATGACTAATTTAATAATTAAAATATTTCTGGGATGTTATAATGAAATCCTA
    ATAGATAACGCTTACGTTTATAATATGAGAAATCATGCTCTAAGTCAAAAAAAATATGTT
    CTGGAAAACGGAGAATGTCCAATTTGTAAAAAAAATAATAAAGTGAAAGATAACAATATT
    AGAGCGAAAACATTTATTCGTTCAGTTTGTTTTTGCTTATTATCAGGAGGAGTAGCTTTT
    TTATCTGCTATTGGGCAGTTCACTGTTATAGAAACACAATTAATAGTATTGTTCTTGGGT
    ATTATTTTTGCTATATATTATGCTTACTACAATAAAAATATTCAAACATCATTGGAAAAT
    ATAGTATGGCTTTTTTCATCGTTTGAGATTTTATTTTTGCTTGTTAATTTTAGAACATTT
    ATTCAGTTACCAGTGGATATTTTTATTGGTATGATAATATTTTTAATGCTGTGGATATTT
    ATTATGTTAGGTATAGTGTGTCTTAGTTATTATATAACTTTATTATTTAGCAAGGAGGCT
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1083

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_RS03145 [old locus tag: A66_00631 ]
  • symbol: A66_RS03145
  • description: HesA/MoeB/ThiF family protein
  • length: 360
  • theoretical pI: 8.05448
  • theoretical MW: 40748.9
  • GRAVY: 0.474167

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.7.-?  ExPASy
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis adenylyltransferase ThiF (TIGR02356; EC 2.7.7.73; HMM-score: 86.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine biosynthesis protein ThiF (TIGR02354; HMM-score: 70.1)
    and 6 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdopterin synthase sulfurylase MoeB (TIGR02355; HMM-score: 66.9)
    ubiquitin-activating enzyme E1 (TIGR01408; HMM-score: 45.3)
    E1-like protein-activating enzyme Gsa7p/Apg7p (TIGR01381; HMM-score: 30.4)
    PRTRC system ThiF family protein (TIGR03736; HMM-score: 16.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 14.1)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides beta-aspartyl peptidase (TIGR01975; EC 3.4.19.5; HMM-score: 13.3)
  • TheSEED: data available for D39, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) ThiF; ThiF family (PF00899; HMM-score: 123.5)
    and 3 more
    Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 15.3)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 13.3)
    FAD_binding_3; FAD binding domain (PF01494; HMM-score: 12.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.33
    • Cytoplasmic Membrane Score: 9.6
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 5
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0066
    • Cytoplasmic Membrane Score: 0.8606
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.1325
  • SignalP: Signal peptide LIPO(Sec/SPII) length 15 aa
    • SP(Sec/SPI): 0.156909
    • TAT(Tat/SPI): 0.004878
    • LIPO(Sec/SPII): 0.498524
    • Cleavage Site: CS pos: 15-16. ALG-CY. Pr: 0.4937
  • predicted transmembrane helices (TMHMM): 7

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_231846868 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQNKTVLVLGAGALGCYISLSLSMYGVRKLIVADYDIIEPSNLNRQILYTESDVGKEKINVLSEKIHKYNSDVQVVPISIKVSSLEELEKIVAEYGSIDFIVKAIDTPIDIIKIVNQFAVSHKISYISGGFNGCYLIIDNIYIPTIGSCFGCRNINKDINKYTLSDKTKWPTTPEMPAILGGIMTNLIIKIFLGCYNEILIDNAYVYNMRNHALSQKKYVLENGECPICKKNNKVKDNNIRAKTFIRSVCFCLLSGGVAFLSAIGQFTVIETQLIVLFLGIIFAIYYAYYNKNIQTSLENIVWLFSSFEILFLLVNFRTFIQLPVDIFIGMIIFLMLWIFIMLGIVCLSYYITLLFSKEA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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