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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_0695 [new locus tag: SP_RS03400 ]
- pan locus tag?: PNEUPAN001607000
- symbol: SP_0695
- pan gene symbol?: moeB
- synonym:
- product: HesA/MoeB/ThiF family protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_0695 [new locus tag: SP_RS03400 ]
- symbol: SP_0695
- product: HesA/MoeB/ThiF family protein
- replicon: chromosome
- strand: +
- coordinates: 664654..665289
- length: 636
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: AE005672 (664654..665289) NCBI
- BioCyc:
- MicrobesOnline: 116199 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_2205 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
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541
601ATGTATGGAGTGAGGAAACTTATTGTCGCTGATTACGATATAATAGAACCATCAAATTTA
AATAGGCAAATTCTTTATACAGAGTCGGATGTTGGTAAGGAGAAGATTAATGTTCTTTCT
GAAAAAATACACAAGTATAATTCAGATGTTCAGGTAGTACCTATTTCTATTAAAGTTTCT
TCAGTAGAAGAATTAGAAAAAATTGTTGCGGAATATGGGAGTATAGATTTTATCGTTAAA
GCAATTGATACGCCCATTGATATTATAAAAATTGTCAATCAATTTGCTGTATCGCATAAG
ATATCCTACATATCAGGAGGGTTTAATGGATGCTATCTTATTATTGATAATATATATATC
CCTACCATCGGTTCTTGCTTTGGTTGTCGGAATATAAACAAAGATATAAATAAGTACACT
TTATCTGATAAGACAAAGTGGCCGACTACACCAGAGATGCCTGCTATTTTGGGAGGGATA
ATGACTAATTTAATAATTAAAATATTTCTGGGATGTTATAATGAAATCCTAATAGATAAC
GCTTACGTTTATAATATGAGAAATCATGCTCTAAGTCAAGAAAAATATGTTCTGGAAAAC
GGAGAATGTCCAATTTGTAAAAAAATAATAAAGTGA60
120
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636
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_0695 [new locus tag: SP_RS03400 ]
- symbol: SP_0695
- description: HesA/MoeB/ThiF family protein
- length: 211
- theoretical pI: 6.74939
- theoretical MW: 23864.7
- GRAVY: 0.0530806
⊟Function[edit | edit source]
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis adenylyltransferase ThiF (TIGR02356; EC 2.7.7.73; HMM-score: 60.9)Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine biosynthesis protein ThiF (TIGR02354; HMM-score: 51.7)and 4 moreBiosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdopterin synthase sulfurylase MoeB (TIGR02355; HMM-score: 46.7)ubiquitin-activating enzyme E1 (TIGR01408; HMM-score: 31.6)PRTRC system ThiF family protein (TIGR03736; HMM-score: 16.6)Protein fate Degradation of proteins, peptides, and glycopeptides beta-aspartyl peptidase (TIGR01975; EC 3.4.19.5; HMM-score: 16.2)
- TheSEED :
- HesA/MoeB/ThiF family protein
- PFAM: NADP_Rossmann (CL0063) ThiF; ThiF family (PF00899; HMM-score: 95.9)and 1 moreEspA_CesA (CL0628) T3SchapCesA; Type III secretion system filament chaperone CesA (PF11439; HMM-score: 10.1)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: unknown (no significant prediction)
- Cytoplasmic Score: 2.5
- Cytoplasmic Membrane Score: 2.5
- Cellwall Score: 2.5
- Extracellular Score: 2.5
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9174
- Cytoplasmic Membrane Score: 0.0447
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.0378
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.003086
- TAT(Tat/SPI): 0.000206
- LIPO(Sec/SPII): 0.000399
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MYGVRKLIVADYDIIEPSNLNRQILYTESDVGKEKINVLSEKIHKYNSDVQVVPISIKVSSVEELEKIVAEYGSIDFIVKAIDTPIDIIKIVNQFAVSHKISYISGGFNGCYLIIDNIYIPTIGSCFGCRNINKDINKYTLSDKTKWPTTPEMPAILGGIMTNLIIKIFLGCYNEILIDNAYVYNMRNHALSQEKYVLENGECPICKKIIK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_2205 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ 1.0 1.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)