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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 03-SEP-2019
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae ASP0581
- locus tag: ASP0581_00120 [new locus tag: EL334_RS00055 ]
- pan locus tag?: PNEUPAN000367000
- symbol: hpt
- pan gene symbol?: hpt
- synonym:
- product: hypoxanthine-guanine phosphoribosyltransferase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: ASP0581_00120 [new locus tag: EL334_RS00055 ]
- symbol: hpt
- product: hypoxanthine-guanine phosphoribosyltransferase
- replicon: chromosome
- strand: +
- coordinates: 11726..12268
- length: 543
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: AP019192 (11726..12268) NCBI
- BioCyc: see EL334_RS00055
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0012 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241
301
361
421
481
541ATGTTAGAAAACGATATTAAAAAAGTCCTCGTTTCACACGATGAAATTACAGAAGCAGCT
AAAAAACTAGGTGCTCAATTAACTAAAGACTATGCAGGAAAAAATCCAATCTTAGTTGGG
ATTTTAAAAGGATCTATTCCTTTTATGGCTGAATTGGTCAAACATATTGATACACATATT
GAAATGGACTTCATGATGGTTTCTAGCTACCATGGTGGAACAGCAAGTAGTGGTGTTATC
AATATTAAACAAGATGTGACTCAAGATATCAAAGGAAGACATGTTCTATTTGTAGAAGAT
ATCATTGATACAGGTCAAACTTTGAAGAATTTGCGAGATATGTTTAAAGCAAGAGAAGCA
GCTTCTGTTAAAATTGCAACCTTGTTGGATAAACCAGAAGGACGTGTTGTAGAAATTGAG
GCAGACTATACCTGCTTTACTATCCCAAATGAGTTTGTAGTAGGTTATGGTTTAGACTAC
AAAGAAAATTATCGTAATCTTCCTTATATTGGAGTATTGAAAGAGGAAGTGTATTCAAAT
TAG60
120
180
240
300
360
420
480
540
543
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: ASP0581_00120 [new locus tag: EL334_RS00055 ]
- symbol: Hpt
- description: hypoxanthine-guanine phosphoribosyltransferase
- length: 180
- theoretical pI: 5.31408
- theoretical MW: 20154.1
- GRAVY: -0.153889
⊟Function[edit | edit source]
- TIGRFAM: Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides hypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 215.2)and 8 morePurines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uracil phosphoribosyltransferase (TIGR01091; EC 2.4.2.9; HMM-score: 28.3)Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis ribose-phosphate diphosphokinase (TIGR01251; EC 2.7.6.1; HMM-score: 25.2)Cellular processes DNA transformation comF family protein (TIGR00201; HMM-score: 18.8)Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine phosphoribosyltransferase (TIGR01090; EC 2.4.2.7; HMM-score: 16.7)Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR01367; EC 2.4.2.10; HMM-score: 16.5)Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR00336; EC 2.4.2.10; HMM-score: 15.9)Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis pur operon repressor PurR (TIGR01743; HMM-score: 13.4)Regulatory functions DNA interactions pur operon repressor PurR (TIGR01743; HMM-score: 13.4)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: PRTase-like (CL0533) Pribosyltran; Phosphoribosyl transferase domain (PF00156; HMM-score: 106.7)and 2 moreEDD (CL0245) EIIA-man; PTS system fructose IIA component (PF03610; HMM-score: 14.7)PRTase-like (CL0533) PRTase_2; Phosphoribosyl transferase (PF15609; HMM-score: 13.1)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9918
- Cytoplasmic Membrane Score: 0.0001
- Cell wall & surface Score: 0
- Extracellular Score: 0.0081
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002476
- TAT(Tat/SPI): 0.000194
- LIPO(Sec/SPII): 0.000543
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: BBG80534 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKAREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDYKENYRNLPYIGVLKEEVYSN
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0012 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
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