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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 13-OCT-2024
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae NCTC7465
- locus tag: AT689_RS04810 [old locus tag: ERS445053_00939 ]
- pan locus tag?: PNEUPAN003378000
- symbol: nmlR
- pan gene symbol?: nmlR
- synonym:
- product: stress response transcriptional regulator NmlR
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: AT689_RS04810 [old locus tag: ERS445053_00939 ]
- symbol: nmlR
- product: stress response transcriptional regulator NmlR
- replicon: chromosome
- strand: +
- coordinates: 886759..887112
- length: 354
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: NZ_LN831051 (886759..887112) NCBI
- BioCyc: AT689_RS04810 BioCyc
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1637 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241
301GTGAATATTAAATCTGCCAGTGATTTGTTGGGAATTTCAGCGGATACGATTCGGTATTAT
GAACGGGTTGGTCTTGTGCCACCGATTACTCGTACTGCTACTGGGATTCGTGATTTTCAA
GATCAGGATATCGAAGCGCTGGAATTTATTAAGTGTTTTCGTTCGGCGGGTGTCTCTGTA
GATAGTTTAGTTGACTATATGTCGCTCTACCAAAAGGGAGATGAAACGAGAGAGGAGAGG
CTTGGTATTTTAGAAGAGGAAAAGCAAAAATTAGAGGAGCGCTTGTCTCAGCTACAGACA
GCTTTAAATCGTTTAAATCTCAAAATTAAACTTTATAAGGAAGGAAAATTTTAA60
120
180
240
300
354
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: AT689_RS04810 [old locus tag: ERS445053_00939 ]
- symbol: NmlR
- description: stress response transcriptional regulator NmlR
- length: 117
- theoretical pI: 4.99223
- theoretical MW: 13463.3
- GRAVY: -0.45641
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions Cu(I)-responsive transcriptional regulator (TIGR02044; HMM-score: 65.3)and 7 moreRegulatory functions DNA interactions Zn(II)-responsive transcriptional regulator (TIGR02043; HMM-score: 49.4)Cellular processes Detoxification Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 47.2)Regulatory functions DNA interactions Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 47.2)Regulatory functions DNA interactions Cd(II)/Pb(II)-responsive transcriptional regulator (TIGR02047; HMM-score: 45.1)Cellular processes Detoxification mercuric resistence transcriptional repressor protein MerD (TIGR02054; HMM-score: 24)Cellular processes Detoxification redox-sensitive transcriptional activator SoxR (TIGR01950; HMM-score: 22.9)Regulatory functions DNA interactions redox-sensitive transcriptional activator SoxR (TIGR01950; HMM-score: 22.9)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: HTH (CL0123) MerR_1; MerR HTH family regulatory protein (PF13411; HMM-score: 58.1)MerR; MerR family regulatory protein (PF00376; HMM-score: 49.4)and 2 moreMerR-DNA-bind; MerR, DNA binding (PF09278; HMM-score: 31.5)NUMOD1; NUMOD1 domain (PF07453; HMM-score: 15.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
- genes regulated by NmlR*, TF important in Carbonyl stress response: in TIGR4
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.006959
- TAT(Tat/SPI): 0.000714
- LIPO(Sec/SPII): 0.000852
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: WP_001022629 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MNIKSASDLLGISADTIRYYERVGLVPPITRTATGIRDFQDQDIEALEFIKCFRSAGVSVDSLVDYMSLYQKGDETREERLGILEEEKQKLEERLSQLQTALNRLNLKIKLYKEGKF
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- data available for TIGR4
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1637 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Uwe H Stroeher, Stephen P Kidd, Sian L Stafford, Michael P Jennings, James C Paton, Alastair G McEwan
A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence.
J Infect Dis: 2007, 196(12);1820-6
[PubMed:18190263] [WorldCat.org] [DOI] (P p)Adam J Potter, Stephen P Kidd, Alastair G McEwan, James C Paton
The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production.
J Bacteriol: 2010, 192(15);4063-6
[PubMed:20525825] [WorldCat.org] [DOI] (I p)