PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 13-OCT-2024

⊟Summary

• organism: Streptococcus pneumoniae NCTC7465
• locus tag: AT689_RS05690 [old locus tag: ERS445053_01112 ]
• pan locus tag^?: PNEUPAN003115000
• symbol: AT689_RS05690
• pan gene symbol^?: axe1
• synonym:
• product: acetylxylan esterase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: AT689_RS05690 [old locus tag: ERS445053_01112 ]
• symbol: AT689_RS05690
• product: acetylxylan esterase
• replicon: chromosome
• strand: +
• coordinates: 1057814..1058794
• length: 981
• essential: unknown

⊟Accession numbers

• Location: NZ_LN831051 (1057814..1058794) NCBI
• BioCyc: AT689_RS05690 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1506 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  
  ATGAAAAATCCAGCTTTGCTAGAAGAAATTAAGACCTATAGAGGAAGGGATGAGGTTCCG
  GAAGACTTTGATGCTTTCTGGGATGGGGAAGTGAAAAATGTTTCCACGCTTCCATCCTAC
  CACTTGGAGGAAAGAGATTTCCACATTCCTCAAGTCAAGTGCTATGAGTTAACATTTGAA
  GGAAGCAAGGAAGGAAAGGTCTATGCACGCATTGTTCTTCCAAAGAGTGAGGAGAAGGTT
  CCACTAATCTTCCATTTTCATGGTTATATGGGACGTGGCTGGGACTGGGCCGACATGCTG
  GGCTTCACCGTAGCTGGTTACGGTGTTGTTTCCATGGATGTGCGGGGCCAGTCAGGTTAC
  TCACAAGACGGCTTGCGTTCTCCTTTAGGAAATACCGTGAAGGGGCATATTATCCGTGGT
  GCTATGGAAGGTCGGGACTACCTCTTTTATAAGGATGTTTATCTGGATATTTACCAGTTG
  GTCGAAATTGTTGCTAGTCTGTCTCAGGTTGATGAGAAGCGTCTTTCTAGCTATGGTGCC
  TCACAAGGAGGGGCTCTAGCTCTAGTTGCAGCAGCGCTCAATCCTCGAATTCAGAAAACA
  GTTGCCATTTATCCCTTCTTGTCAGACTTCAGACGGGTGATTGAGATTGGTAATACTAGC
  GAGGCTTACGACGAACTTTTCCGTTATTTCAAGTTTCACGACCCCTTCCATGAAACAGAG
  GAGGAAATCATGGCGACCCTTGCCTATATCGATGTCAAAAATCTTGCCCATCGTATCCAA
  GGTGAGGTTAAGATGATTACGGGCTTGGACGACAATGTTTGCTATCCCATTACCCAGTTT
  GCGATTTATAATCGTCTGACCTGCGATAAAACCTATCGCATCATGCCTGAGTATGCTCAC
  GAAGCCATGAATGTATTTGTCAATGACCAAGTCTACAACTGGCTCTGTGGAAGTGAGATT
  CCTTTTAAATATCTAAAATAA
  60
  120
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  420
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  540
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  840
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  960
  981
  

⊟Protein

⊟General

• locus tag: AT689_RS05690 [old locus tag: ERS445053_01112 ]
• symbol: AT689_RS05690
• description: acetylxylan esterase
• length: 326
• theoretical pI: 5.1356
• theoretical MW: 37470.4
• GRAVY: -0.281288

⊟Function

• reaction:
  EC 3.1.1.-?  ExPASy
• TIGRFAM:
  Metabolism Fatty acid and phospholipid metabolism Biosynthesis poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit (TIGR01836; HMM-score: 16.4)
  Unknown function Enzymes of unknown specificity hydrolase CocE/NonD family protein (TIGR00976; HMM-score: 16.2)
  and 2 more
  Cellular processes Cellular processes Detoxification S-formylglutathione hydrolase (TIGR02821; EC 3.1.2.12; HMM-score: 12.5)
  Metabolism Energy metabolism Photosynthesis putative magnesium chelatase accessory protein (TIGR03056; HMM-score: 12.1)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  AB_hydrolase (CL0028) AXE1; Acetyl xylan esterase (AXE1) (PF05448; HMM-score: 466.5)
  and 9 more
  Peptidase_S9; Prolyl oligopeptidase family (PF00326; HMM-score: 37.2)
  Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 34.4)
  Peptidase_S15; X-Pro dipeptidyl-peptidase (S15 family) (PF02129; HMM-score: 27.1)
  DLH; Dienelactone hydrolase family (PF01738; HMM-score: 22.1)
  Abhydrolase_6; Alpha/beta hydrolase family (PF12697; HMM-score: 20.1)
  Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 19.8)
  Abhydrolase_3; alpha/beta hydrolase fold (PF07859; HMM-score: 13)
  Esterase; Putative esterase (PF00756; HMM-score: 12.9)
  BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal (PF08840; HMM-score: 12.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9505
  • Cytoplasmic Membrane Score: 0.0141
  • Cell wall & surface Score: 0.0007
  • Extracellular Score: 0.0348
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.006518
  • TAT(Tat/SPI): 0.000921
  • LIPO(Sec/SPII): 0.001063
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000795120 NCBI
• UniProt:

⊟Protein sequence

• MKNPALLEEIKTYRGRDEVPEDFDAFWDGEVKNVSTLPSYHLEERDFHIPQVKCYELTFEGSKEGKVYARIVLPKSEEKVPLIFHFHGYMGRGWDWADMLGFTVAGYGVVSMDVRGQSGYSQDGLRSPLGNTVKGHIIRGAMEGRDYLFYKDVYLDIYQLVEIVASLSQVDEKRLSSYGASQGGALALVAAALNPRIQKTVAIYPFLSDFRRVIEIGNTSEAYDELFRYFKFHDPFHETEEEIMATLAYIDVKNLAHRIQGEVKMITGLDDNVCYPITQFAIYNRLTCDKTYRIMPEYAHEAMNVFVNDQVYNWLCGSEIPFKYLK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1506 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications