PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 09-DEC-2016

⊟Summary

• organism: Streptococcus pneumoniae SP49
• locus tag: BMJ42_02317 [new locus tag: BMJ42_RS12195 ]
• pan locus tag^?: PNEUPAN003950000
• symbol: parB
• pan gene symbol^?: parB
• synonym:
• product: chromosome partitioning protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: BMJ42_02317 [new locus tag: BMJ42_RS12195 ]
• symbol: parB
• product: chromosome partitioning protein
• replicon: chromosome
• strand: +
• coordinates: 2205689..2206432
• length: 744
• essential: unknown

⊟Accession numbers

• Location: CP018136 (2205689..2206432) NCBI
• BioCyc: see BMJ42_RS12195
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_2069 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  
  ATGATTTCTATCACAGATATACAAAAAAATCCCTATCAACCCCGAAAAGAATTTGATAGA
  GAAAAACTAGATGAACTAGCACAGTCTATCAAAGAAAATGGGGTCATTCAACCGATTATT
  GTTCGTCAATCTCCTGTTATTGGTTATGAAATCCTTGCAGGAGAGAGACGCTATCGGGCT
  TCACTTTTAGCTGGTCTACGGTCTATCCCAGCTGTTGTTAAACAGATTTCAGACCAAGAG
  ATGATGGTCCAGTCCATTATTGAAAATTTACAGAGAGAAAATTTAAACCCAATAGAAGAA
  GCACGCGCCTATGAATCTCTCGTAGAGAAAGGATTCACCCATGCTGAAATTGCAGATAAG
  ATGGGCAAGTCTCGTCCATATATCAGCAACTCCATTCGTTTACTTTCCTTGCCAGAACAG
  ATTCTCTCAGAAGTAGAAAATGGCAAACTATCACAAGCCCATGCGCGTTCCCTAGTTGGG
  TTAAATAAGGAACAACAAGACTATTTCTTTCAACGGATTATAGAAGAAGATATTTCTGTA
  AGGAAGTTAGAAACTCTTCTGACAGAGAAAAAACAAAAGAAACAGCAAAAAACTAATCAT
  TTCATACAAAATGAAGAAAAACAGTTAAGAAAACTACTCGGTTTAGATGTAGAAATTAAA
  CTATCTAAAAAAGACAGTGGAAAAATCATTATTTCTTTTTCAAATCAAGAAGAATATAGT
  AGAATTATCAACAGCCTGAAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  744
  

⊟Protein

⊟General

• locus tag: BMJ42_02317 [new locus tag: BMJ42_RS12195 ]
• symbol: ParB
• description: chromosome partitioning protein
• length: 247
• theoretical pI: 9.41818
• theoretical MW: 28518.5
• GRAVY: -0.58664

⊟Function

• TIGRFAM:
  nucleoid occlusion protein (TIGR04285; HMM-score: 221.8)
  ParB/RepB/Spo0J family partition protein (TIGR00180; HMM-score: 194.2)
  and 2 more
  PRTRC system ParB family protein (TIGR03734; HMM-score: 131)
  Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid partitioning protein RepB (TIGR03454; HMM-score: 73.6)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  ParBc (CL0248) ParBc; ParB/Sulfiredoxin domain (PF02195; HMM-score: 98.8)
  and 9 more
  HTH (CL0123) HTH_ParB; HTH domain found in ParB protein (PF17762; HMM-score: 48.1)
  RepB; RepB plasmid partitioning protein (PF07506; HMM-score: 27.5)
  KorB; KorB domain (PF08535; HMM-score: 19.9)
  HTH_3; Helix-turn-helix (PF01381; HMM-score: 18.1)
  no clan defined Mu-like_Pro; Mu-like prophage I protein (PF10123; HMM-score: 16.9)
  HTH (CL0123) TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 15.1)
  HTH_23; Homeodomain-like domain (PF13384; HMM-score: 14.9)
  Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 13.8)
  Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 13.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9815
  • Cytoplasmic Membrane Score: 0.0101
  • Cell wall & surface Score: 0.0019
  • Extracellular Score: 0.0064
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.005077
  • TAT(Tat/SPI): 0.000646
  • LIPO(Sec/SPII): 0.000566
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: APJ31532 NCBI
• UniProt:

⊟Protein sequence

• MISITDIQKNPYQPRKEFDREKLDELAQSIKENGVIQPIIVRQSPVIGYEILAGERRYRASLLAGLRSIPAVVKQISDQEMMVQSIIENLQRENLNPIEEARAYESLVEKGFTHAEIADKMGKSRPYISNSIRLLSLPEQILSEVENGKLSQAHARSLVGLNKEQQDYFFQRIIEEDISVRKLETLLTEKKQKKQQKTNHFIQNEEKQLRKLLGLDVEIKLSKKDSGKIIISFSNQEEYSRIINSLK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_2069 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications

Anita Minnen, Laetitia Attaiech, Maria Thon, Stephan Gruber, Jan-Willem Veening
SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae.
Mol Microbiol: 2011, 81(3);676-88
[PubMed:21651626] [WorldCat.org] [DOI] (I p)