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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS03940 [old locus tag: NCTC7466_00755 ]
  • pan locus tag?: PNEUPAN001808000
  • symbol: DQM66_RS03940
  • pan gene symbol?: flaR
  • synonym:
  • product: DNA topology modulation protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS03940 [old locus tag: NCTC7466_00755 ]
  • symbol: DQM66_RS03940
  • product: DNA topology modulation protein
  • replicon: chromosome
  • strand: -
  • coordinates: 745226..745750
  • length: 525
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (745226..745750) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0731 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAAAATCACAATTATCGGATATTCTGGTTCTGGTAAGTCAACTCTAGCAGAAAAGTTA
    TCTAACTACTACTCCATTCCAAAACTGCACATGGACACACTCCAATTTCAACCTGGTTGG
    CAAGACAGTGACTGCGAATGGATGTTAACCGAGATAAAAAACTTTCTCACCAAGCATAAA
    GCTTGGGTCATCGATGGTAATTATTCTTGGTGCTACTACCAAGAACGAATGCAAGAAGCT
    GACCAAATCATCTTTCTCAATTTTTTGCCATTGACCTGTCTCTTTAGAGCCTTTAAGCGT
    TATCTTAAATACCGTGGAAAAGTCAGAGAAAGTATGGCGGCAGATTGCCCTGAACGCTTT
    GAGTGGGAGTTTATCAGATGGATTCTTTGGGATGGGCGTAGCAAAACTCAAAAAGAAAAT
    TACCAAAAACTTTGCCAAGAATATTCACATAAAGTCACTATCCTTCGAAATCAGAGAGAG
    CTAGATCAATTTCTGGATAAGAAAAGGAAGTCCTACAATTCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    525

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS03940 [old locus tag: NCTC7466_00755 ]
  • symbol: DQM66_RS03940
  • description: DNA topology modulation protein
  • length: 174
  • theoretical pI: 9.26926
  • theoretical MW: 21135.1
  • GRAVY: -0.724138

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 18.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 18.2)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 17.8)
    putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 16.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 15.6)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 15.6)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 15.6)
    and 21 more
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 13.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 13.6)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 13.1)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 13.1)
    Metabolism Energy metabolism Amino acids and amines ethanolamine utilization protein, EutP (TIGR02528; HMM-score: 13)
    carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 12.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 12.9)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 12.1)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 11.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 11.7)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 11.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 11.5)
    Unknown function General GTP-binding protein HflX (TIGR03156; HMM-score: 11.5)
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 11.4)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 11.4)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 11.3)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 11.3)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 10.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 10.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 9.9)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 9.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) AAA_18; AAA domain (PF13238; HMM-score: 24)
    and 21 more
    AAA_22; AAA domain (PF13401; HMM-score: 17.8)
    ABC_tran; ABC transporter (PF00005; HMM-score: 17.7)
    AAA_33; AAA domain (PF13671; HMM-score: 16.8)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 16.6)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 16.2)
    PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 16.1)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 15.4)
    AAA_17; AAA domain (PF13207; HMM-score: 15.4)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 15)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 14.9)
    AAA_24; AAA domain (PF13479; HMM-score: 14.4)
    AAA_28; AAA domain (PF13521; HMM-score: 14.2)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.8)
    MobB; Molybdopterin guanine dinucleotide synthesis protein B (PF03205; HMM-score: 13)
    NACHT; NACHT domain (PF05729; HMM-score: 13)
    PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 12.9)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 12.7)
    APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 12.6)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 12.2)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 12.2)
    AAA_23; AAA domain (PF13476; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.034514
    • TAT(Tat/SPI): 0.000376
    • LIPO(Sec/SPII): 0.008253
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000704762 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKITIIGYSGSGKSTLAEKLSNYYSIPKLHMDTLQFQPGWQDSDCEWMLTEIKNFLTKHKAWVIDGNYSWCYYQERMQEADQIIFLNFLPLTCLFRAFKRYLKYRGKVRESMAADCPERFEWEFIRWILWDGRSKTQKENYQKLCQEYSHKVTILRNQRELDQFLDKKRKSYNS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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