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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS07465 [old locus tag: SPAT_1423 ]
  • pan locus tag?: PNEUPAN002831000
  • symbol: EL263_RS07465
  • pan gene symbol?: pclA
  • synonym:
  • product: pneumococcal collagen-like adhesin PclA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS07465 [old locus tag: SPAT_1423 ]
  • symbol: EL263_RS07465
  • product: pneumococcal collagen-like adhesin PclA
  • replicon: chromosome
  • strand: -
  • coordinates: 1408161..1413551
  • length: 5391
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (1408161..1413551) NCBI
  • BioCyc: EL263_RS07465 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1376 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
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    1201
    1261
    1321
    1381
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    5041
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    5221
    5281
    5341
    ATGAAACATTCACATAAAAAATCATTTGACTGGTATAGCATGCAACAACGTTATTCTATT
    CGTAAGTATTACTTTGGTGCAGCTAGTGTCTTGCTCGGTACCGCTTTGGTATTAGGTGCA
    GCAGCTAGTGTCCAAACAGTACAAGCGGAAGAAAACAAACAAGAAACTACCAATAGTATT
    TCTGTTGGTAGGGGAGAAGCAGCTACTAAACCAGCAGAGGTTTCTGCGTCTAATAAAGAG
    AAAACCTATGCAGCTCCAACTGTAGCTAATCCAGTAGAAACGACTCCAGTTAAAACTGAA
    GAAGTTACTAAACCAGCAGAAAAAGTTGAAGAAGCAAAAGACAAAAAAGAGGAAGTAACG
    CATCAAGATGCCGTTGACAAGTCAAAATTATTAACAGCTCTTTCGCGTGCTAAAAAATTA
    GAAAGCAAGTTATATACAGAAGCAAGTGCTGCTAACTTGCAAACAAGTATCCAAGCTGGT
    CAAAGCTTGCTTGGAAAAGCAGATGCAACTGAAGCTGAATTATCAGCAGCAGAGTCATCT
    ATTCAATCATTTATTATTGGTCTAGAACTTCGTCCTAACTCTAACAAAGGAACTGTATCA
    GAAACGCCTGTAGCAAAGAAAGCTAATATAGTTGAAGCGAAGGAAGAGACTAATCCAGCT
    GCAACAACTGATCGTTCAGCTGTTGATAGCGCTGTTTTGCCAACTAGCACAGCTGCTAAA
    GTAGAAACAACTTCAGCTCCAGCATCTACTAATGAAATCTTGAAACCAGGTTTGAGCCTT
    TCTGATGCTCGCCAAAATCCAGCTATCCGTAAGGAAGATGTTGATAGGGGGTATAGTGGT
    TTTAGAACAGCAGGAAGTGGTTTTAGAGCAGCTGGACCAGAAAATAAACCAATCTTAAAT
    CCAAATAATACTATTGCATTTTCTGACATCAGTCAGGGCTCACATTCATTTCGTGGTATA
    GGACATTCACGTGGTGGTCGTGAAATCCATTATGATGTAACGACAGTACGTAGAGGCAAT
    AATATTAACTTTACAATTAATTATTTTGCGCCAGGAAATCTTAGAGAGTTTGTTAATAAC
    AACTTTATCTTAGATAAGGGAACAGGTTATGGTGAACCTACACCTGCTACTGTTATAACA
    CCAAACTTAAGAAACCAAGTTAAAAACATTAGTAAGGGTGGAAACTTTGTTTCTCATTCA
    GGCTACAGTTTAGAAGCTGCAGTAGAAACAAACAAAAGTCAAACAATTACGTTTAGTTTA
    CCTATAACTAACCCTAACGGAGATTTATCTCTTCGTTTACGTCCAGTTGAATTTAACGTA
    GACCAAGGTGGTAGTGGAACTGGGACTAGTAATGATCCATATAGTAATTCTAACTATTAT
    TTTGAAACGGATCCATTGTATCTAGATGCAAATCCAAATCAAGCTAATCCTTTAACAACA
    AGTTTTAATACTAAAGTTGATTTCCAAACTTTATATATACCAACTACTAAATTAGCAGAA
    GGAGTAACGGAGTTAGTTTCTGAAGGGGTAGAAGGAGAGAAATCACAAGCATACAGACTT
    CATAAATTTGGAGATCAGTATGTTTTAGGACTTCCTGTAGGGAATGCTACTACAGTTACA
    GCTGCTAAACCTCGTGTAATGAAATACGGTATTGGTAAAATTGCTGCAACTCAAAATAAA
    ACAGGGGATACGAATCACATTAAATTTTATTTAGATAAAGATGGTGATGGTGTCTTTAAT
    AATCAAGATGAAGTAATTTTAAATACAGATATTAAAGATGGAGAAAGAGGGCCAACAGGT
    GCAACTGGGGCACAAGGACCAGCAGGACCAAAAGGAGAACAAGGTAATCCAGGAACTCCA
    GGTAAAGATGGAAAATCTCTAATTGCTGTTAAAAATGGAACTGAAACAAAAGTCTATGTA
    GAGGATCCGGCTAGACCAGGACAACCACTTAATCCAAACCAACCATTAGCAACTATCACT
    GATGGAAGAAACGGTACTAATGGACAATCACCAACAATTACAGCGACACGAAGTGTGCAA
    AATGGCAAAAATGGTGTATTAGTAACAATTACACCAGTAGGAGGTCGTCCACAAACAACA
    TTTGTAGAGGATGGACAAAAGGGTGCTGATGGGAAAACCCCAACAGTAACAATAACTGAG
    GGGCAAAACGGCACACATACATTAACGGTTCATAATCCAGGAAGTCCAGATGTGACAACT
    ACGATCCGTGATGGAGCTACAGGACAAGCAGGTCGTGATGGTAAAGATGTATTAAACGGA
    AAAGTAAATCCACAACCAAACCAAGGTAAAAATGGAGATAAATATATTAATACCGAAACC
    GGTGATGTCTATGTTAAAAACAATGGAAACTGGGATAAAGAAGGCAACATCAAAGGCCCT
    AAAGGGGACAAAGGTGCAGATGGTGCTAAAGGCGAAAAAGGAGACCAAGGCGAACGCGGC
    CTAACTGGAGCGCAAGGAGCTAAAGGTGCGGATGGCGCAGTAGGTCGTGATGGACGTGAC
    GGTAAAGACGTCTTGAACGGCAAAGCTAACCCAGAAGCACATCAAGGTAAAGACGGCGAT
    AAATACGTTAATACAGAAACAGGCGATGTCTTCGTTAAGAATAACGGCAACTGGGATAAA
    GAGGGCAACATCAAAGGCCCTAAGGGTGACAAAGGTGAACGCGGAGAAGATGGTAAGACT
    CCAGAAGTAACTGTAACTCCAGGTAAAGATGGCCATAGTACTGACATTACATTCACTGTT
    CCAGGTAAAGATCCAGTTACAGTAAATGTTAAGGACGGAGAAAATGGTCTGAACGGTAAA
    ACTCCAAAAGTTGATTTACTTCGTGTCCAAGGAAAAAACGGAAATCCATCTCATACAATT
    GTGACATTCTATACAGATGAAAACAATGACGGCAAATATACACCAGGAACTGATGAACTT
    CTAGGTTCAGAAATGATTAAAGATGGTGCTAAAGGCGCGGACGGACGAGATGGTAAATCA
    TTGCTTACTGTCAAGGATGGTAAAGAAACTAAAGTTTACCAAGAAGATCCAGCTAACCCA
    GGACAACCATTAAATCCAGAAAAACCACTTGCGGTAATTAGAGATGGAGTAGATGGAAAA
    TCACCTACAGTTACAGCTGTTCGTAAAGATGAAGCAGGGCATAAAGGTGTAGAAATCACT
    GTTGATAACCATGATGGTTCACAACCAACTACAGTCTTTGTTCAAGATGGTGCTAAGGGA
    GAAACTGGTGCAACCGGTCAGGATGGACAAACTCCTACAATCACTACTCAACGTGGACAA
    GATGGCCAAAGCACTGTTGTAACTATCACAACATCAGGTAAAGATCCAGTAACCTTCACT
    GTAAAAGATGGTAAGAATGGTAAAGATGGCCGTGCACCGAAAATCAAAGTAGAAGATATT
    ACTTCACCTTCAAGAATTAGACGCGATACAGATGCTGCTGCAACTCCAACGCGTAACGGT
    ATCCGTGTTACAGTTTATGATGATGTTAATGACAATGGGGTATACGACGAAGGTGTCGAT
    AAAGTATTAAATAGTAAAGATATTTATAACGGTATAGATGGACGTGATGGTTCAGCTCCA
    ACTATTACTACAAAAGATAATGGAGATGGAACTCACACTATCACAGTTCAAAACCCAGAT
    GGTTCTGAATCAACAACAGTTGTTAAAGATGGTAAAGACGGTAAAACTGCGAATATCACT
    ACAACAGAAAACCCAGATGGAAGCCACACAATTACGGTGACAAATCCAGATGGTTCAACT
    AAAGAAACTGTTGTTAAAAACGGTAAAGACGGTAAGACTCCTAAAGTTGAAGTAACGGAT
    AACAACGATGGAACTCATACTGTTAAAGTTACAGATGGAGACGGCAATGTTACCAACGCT
    ATCATCAAAGATGGTAAAGACGGTAAAGCTGCAACAGCAACAACTACTGAAAATCCAGAT
    GGAAGCCACACAGTAACAATCACTAACCCAGACGGAACTAAGAATGAGTTTGTTGTTAAG
    AATGGACGTGACGGTGTTGACGGACGTACTCCAACCGCATCTGTTCGTGATAATGGAGAC
    GGAAGTCATACAATCGTTATTACAAATCCAGAAGGTGTGACAACTGAAACCACAGTTCGT
    GATGGTAAATCACCAAAAGTGACTATAACTGATGAACAAAATGGAACTCATAAGATCTCT
    GTTCTAAATGGTGACGGAACAACTACTGAAACAATCATTACAGATGGTAAATCACCAGTA
    GCAACAGTTAGAGATAACCAAGATGGTACTTACACTATTCGTGTGGAAAACGGTAATGGT
    ACTGTTTCTGAAACCACAGTTCGTGACGGTAAATCACCAACTGCTAAGGTTGTGGATAAT
    GGAGATGGAACTCACACTATCACAGTTGTGAACTCAGACGGAACAACTACAACAACTACA
    GTTCGTGATGGTAGAGAACCAAAACTTGAAGTTATTGATAACAACGATGGTTCACACACT
    ATTAAAGTGACAGGTGCTGATGGTAAAGGAACGACAACTACAATCTTTGATGGTAAATCA
    CCAAAAGCGAACATCGTTGATAACGGAGATGGAACTCATACATTAACAATCGTAGATTCT
    GATGGTCGTGAATACAAATCTATTATCAAAGATGGTAAAGACGGCAAAGATAGCGTTTCA
    CCAACTGTAACTGTTAAAAATAATAACGATGGAACTCACGTTGTTACAATCACTAATCCA
    GATGGAAGTAAGACAGAAATGGTGATTAAAGACGGTAAAGATGGTAAATCACCAAAAGTT
    TCTGTTGAAGATAATGGTGATGGTAGTCATACAATCACAATCATCAATTCTGATGGAACT
    GTGACAAAAACAGTTATTAAAGATGGCAAAGATGGTAGAGATGGACGTGATGGTCGAGAC
    GGCAAAGACGGTAAAGATGGAAAATGTGGATGCCAAGACAAACCAGTAACACCATCAAAT
    GACAAACCAGTTCCTCCAACACCAAATGTGCCGACACCAGAAGTACCGGTTAAACCTGTG
    CCAGCGCAACCAACACCAAATGTGCCGACACCAGAAGTACCGGTTAAACCTGTGCCAGCG
    CAACCAACACCAAATGTACCGACACCAGAAGTGCCAGTACAACCAACTCCAGCTGTTCCA
    ACACCAGAAGTACCGGTTAAACCAGTACCAGCGGTTCCAGAACAACCAGTAGTACCAACA
    CCGGCTCAACCAGCAACTCCAGTAAATGCTAACCCAGTAGCACCAACTACAGGTAAAGAA
    AACCGTGGGGACAAATTACCTGAAACTGGAAGCCAATCTGATTATATCTCTGTTCTTTTA
    GGTAGCGGTATTCTATTGAGCCTATATGTAGGACGAAGAAAAGAAGATTAA
    60
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    5220
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    5391

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS07465 [old locus tag: SPAT_1423 ]
  • symbol: EL263_RS07465
  • description: pneumococcal collagen-like adhesin PclA
  • length: 1796
  • theoretical pI: 5.48968
  • theoretical MW: 188715
  • GRAVY: -0.798107

⊟Function[edit | edit source]

  • TIGRFAM:
    Streptococcal surface-anchored protein repeat, S. criceti family (TIGR04203; HMM-score: 486.4)
    and 3 more
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 36.8)
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 17.2)
    Por secretion system C-terminal sorting domain (TIGR04183; HMM-score: 12.3)
  • TheSEED: data available for D39
  • PFAM:
    no clan defined CFSR; Collagen-flanked surface repeat (PF19079; HMM-score: 521.4)
    and 8 more
    Collagen; Collagen triple helix repeat (20 copies) (PF01391; HMM-score: 45.1)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 34.7)
    E-set (CL0159) BiPBP_C; Penicillin-Binding Protein C-terminus Family (PF06832; HMM-score: 29.6)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 13)
    DUF4795; Domain of unknown function (DUF4795) (PF16043; HMM-score: 12.1)
    E-set (CL0159) Por_Secre_tail; Secretion system C-terminal sorting domain (PF18962; HMM-score: 11.8)
    no clan defined PGDYG; PGDYG protein (PF14083; HMM-score: 10.9)
    GHD (CL0369) Glyco_hydro_30C; Glycosyl hydrolase family 30 beta sandwich domain (PF17189; HMM-score: 7.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 9.99
    • Extracellular Score: 0.01
    • Internal Helix: 1
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0004
    • Cytoplasmic Membrane Score: 0.0007
    • Cell wall & surface Score: 0.9858
    • Extracellular Score: 0.0131
  • SignalP: Signal peptide SP(Sec/SPI) length 49 aa
    • SP(Sec/SPI): 0.924761
    • TAT(Tat/SPI): 0.046501
    • LIPO(Sec/SPII): 0.005667
    • Cleavage Site: CS pos: 49-50. VQA-EE. Pr: 0.9020
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_050221143 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKHSHKKSFDWYSMQQRYSIRKYYFGAASVLLGTALVLGAAASVQTVQAEENKQETTNSISVGRGEAATKPAEVSASNKEKTYAAPTVANPVETTPVKTEEVTKPAEKVEEAKDKKEEVTHQDAVDKSKLLTALSRAKKLESKLYTEASAANLQTSIQAGQSLLGKADATEAELSAAESSIQSFIIGLELRPNSNKGTVSETPVAKKANIVEAKEETNPAATTDRSAVDSAVLPTSTAAKVETTSAPASTNEILKPGLSLSDARQNPAIRKEDVDRGYSGFRTAGSGFRAAGPENKPILNPNNTIAFSDISQGSHSFRGIGHSRGGREIHYDVTTVRRGNNINFTINYFAPGNLREFVNNNFILDKGTGYGEPTPATVITPNLRNQVKNISKGGNFVSHSGYSLEAAVETNKSQTITFSLPITNPNGDLSLRLRPVEFNVDQGGSGTGTSNDPYSNSNYYFETDPLYLDANPNQANPLTTSFNTKVDFQTLYIPTTKLAEGVTELVSEGVEGEKSQAYRLHKFGDQYVLGLPVGNATTVTAAKPRVMKYGIGKIAATQNKTGDTNHIKFYLDKDGDGVFNNQDEVILNTDIKDGERGPTGATGAQGPAGPKGEQGNPGTPGKDGKSLIAVKNGTETKVYVEDPARPGQPLNPNQPLATITDGRNGTNGQSPTITATRSVQNGKNGVLVTITPVGGRPQTTFVEDGQKGADGKTPTVTITEGQNGTHTLTVHNPGSPDVTTTIRDGATGQAGRDGKDVLNGKVNPQPNQGKNGDKYINTETGDVYVKNNGNWDKEGNIKGPKGDKGADGAKGEKGDQGERGLTGAQGAKGADGAVGRDGRDGKDVLNGKANPEAHQGKDGDKYVNTETGDVFVKNNGNWDKEGNIKGPKGDKGERGEDGKTPEVTVTPGKDGHSTDITFTVPGKDPVTVNVKDGENGLNGKTPKVDLLRVQGKNGNPSHTIVTFYTDENNDGKYTPGTDELLGSEMIKDGAKGADGRDGKSLLTVKDGKETKVYQEDPANPGQPLNPEKPLAVIRDGVDGKSPTVTAVRKDEAGHKGVEITVDNHDGSQPTTVFVQDGAKGETGATGQDGQTPTITTQRGQDGQSTVVTITTSGKDPVTFTVKDGKNGKDGRAPKIKVEDITSPSRIRRDTDAAATPTRNGIRVTVYDDVNDNGVYDEGVDKVLNSKDIYNGIDGRDGSAPTITTKDNGDGTHTITVQNPDGSESTTVVKDGKDGKTANITTTENPDGSHTITVTNPDGSTKETVVKNGKDGKTPKVEVTDNNDGTHTVKVTDGDGNVTNAIIKDGKDGKAATATTTENPDGSHTVTITNPDGTKNEFVVKNGRDGVDGRTPTASVRDNGDGSHTIVITNPEGVTTETTVRDGKSPKVTITDEQNGTHKISVLNGDGTTTETIITDGKSPVATVRDNQDGTYTIRVENGNGTVSETTVRDGKSPTAKVVDNGDGTHTITVVNSDGTTTTTTVRDGREPKLEVIDNNDGSHTIKVTGADGKGTTTTIFDGKSPKANIVDNGDGTHTLTIVDSDGREYKSIIKDGKDGKDSVSPTVTVKNNNDGTHVVTITNPDGSKTEMVIKDGKDGKSPKVSVEDNGDGSHTITIINSDGTVTKTVIKDGKDGRDGRDGRDGKDGKDGKCGCQDKPVTPSNDKPVPPTPNVPTPEVPVKPVPAQPTPNVPTPEVPVKPVPAQPTPNVPTPEVPVQPTPAVPTPEVPVKPVPAVPEQPVVPTPAQPATPVNANPVAPTTGKENRGDKLPETGSQSDYISVLLGSGILLSLYVGRRKED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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