PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 12-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae NU83127
• locus tag: EL277_RS02845 [old locus tag: SPNU_0535 ]
• pan locus tag^?: PNEUPAN001445000
• symbol: EL277_RS02845
• pan gene symbol^?: —
• synonym:
• product: helix-hairpin-helix domain-containing protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EL277_RS02845 [old locus tag: SPNU_0535 ]
• symbol: EL277_RS02845
• product: helix-hairpin-helix domain-containing protein
• replicon: chromosome
• strand: +
• coordinates: 534949..535344
• length: 396
• essential: unknown

⊟Accession numbers

• Location: NZ_AP018936 (534949..535344) NCBI
• BioCyc: EL277_RS02845 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0490 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
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  301
  361
  
  ATGTCAAAGAAACTCAATCGTAAAAAACAATTACGAAATGGCCTCCGTCGCGCAGGTGCC
  TTTTCAAGTACGGTGACTAAGGTTGTAGATGAGACAAAAAAAGTCGTGAAGCGTGCAGAA
  CAGTCAGCAAGCGCAGCTGGTAAGGCTATTTCTAAAAAAGTTGAACAAGCAGTAGAAGCT
  ACCAAAGAGCAAGCTCAAAAAGTAGCTAATTCTGTAGAAGATTTTGCAGCAAATTTGGGT
  GGACTTCCACTTGATCGTGCCAAGACTTTCTATGATGAAGGAATCAAGTCTGCTTCAGAT
  TTCAAAAACTGGACTGAAAAAGAACTCCTTGCCTTGAAAGGAATCGGCCCAGCTACCATC
  AAGAAATTGAAAGAAAATGGCATCAAGTTCAAGTAA
  60
  120
  180
  240
  300
  360
  396
  

⊟Protein

⊟General

• locus tag: EL277_RS02845 [old locus tag: SPNU_0535 ]
• symbol: EL277_RS02845
• description: helix-hairpin-helix domain-containing protein
• length: 131
• theoretical pI: 10.8401
• theoretical MW: 14308.4
• GRAVY: -0.641221

⊟Function

• TIGRFAM:
  Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage tail tape measure protein, TP901 family, core region (TIGR01760; HMM-score: 18.4)
  and 1 more
  Metabolism Transport and binding proteins Amino acids, peptides and amines mitochondrial import inner membrane, translocase subunit (TIGR00984; HMM-score: 14.4)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  HHH (CL0198) HHH_5; Helix-hairpin-helix domain (PF14520; HMM-score: 25.3)
  no clan defined ApoLp-III; Apolipophorin-III precursor (apoLp-III) (PF07464; HMM-score: 24.7)
  and 11 more
  HHH (CL0198) HHH; Helix-hairpin-helix motif (PF00633; HMM-score: 17.9)
  no clan defined DUF763; Protein of unknown function (DUF763) (PF05559; HMM-score: 17)
  BAF; Barrier to autointegration factor (PF02961; HMM-score: 16.8)
  DinB (CL0310) DUF1993; Domain of unknown function (DUF1993) (PF09351; HMM-score: 14.7)
  HHH (CL0198) HHH_8; Helix-hairpin-helix domain (PF14716; HMM-score: 14.4)
  no clan defined DUF5024; Domain of unknown function (DUF5024) (PF16427; HMM-score: 14.2)
  VBS-like (CL0705) GCIP; Grap2 and cyclin-D-interacting (PF13324; HMM-score: 14.1)
  no clan defined DUF6468; Domain of unknown function (DUF6468) (PF20072; HMM-score: 13.2)
  HHH (CL0198) DNA_pol_lambd_f; Fingers domain of DNA polymerase lambda (PF10391; HMM-score: 13.1)
  no clan defined Fib_alpha; Fibrinogen alpha/beta chain family (PF08702; HMM-score: 12.4)
  YtxH; YtxH-like protein (PF12732; HMM-score: 8.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Extracellular
  • Cytoplasmic Score: 0.1584
  • Cytoplasmic Membrane Score: 0.2313
  • Cell wall & surface Score: 0.118
  • Extracellular Score: 0.4923
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.040851
  • TAT(Tat/SPI): 0.034599
  • LIPO(Sec/SPII): 0.006893
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_126443093 NCBI
• UniProt:

⊟Protein sequence

• MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQSASAAGKAISKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASDFKNWTEKELLALKGIGPATIKKLKENGIKFK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0490 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications