PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 22-NOV-2024

⊟Summary

• organism: Streptococcus pneumoniae P1031
• locus tag: SPP_RS02855 [old locus tag: SPP_0581 ]
• pan locus tag^?: PNEUPAN001445000
• symbol: SPP_RS02855
• pan gene symbol^?: —
• synonym:
• product: helicase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPP_RS02855 [old locus tag: SPP_0581 ]
• symbol: SPP_RS02855
• product: helicase
• replicon: chromosome
• strand: +
• coordinates: 519887..520282
• length: 396
• essential: unknown

⊟Accession numbers

• Location: NC_012467 (519887..520282) NCBI
• BioCyc: SPP_RS02855 BioCyc
• MicrobesOnline: see SPP_0581
• PneumoBrowse for strain D39V: SPV_0490 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  
  ATGTCAAAGAAACTCAATCGTAAAAAACAATTACGAAATGGCCTCCGTCGCGCAGGTGCC
  TTTTCAAGTACTGTGACTAAGGTTGTAGATGAGACAAAAAAAGTCGTGAAGCGTGCAGAA
  CAGACAGCAAGCGCAGCTGGTAAGGCTGTTTCTAAAAAAGTTGAACAAGCAGTAGAAGCT
  ACCAAAGAGCAAGCTCAAAAAGTAGCTAATTCTGTAGAAGATTTTGCAGCAAATTTGGGT
  GGACTTCCACTTGATCGTGCCAAGACTTTCTATGATGAAGGAATCAAGTCTGCTTCACAT
  TTCAAAAACTGGACTGAAAAAGAACTCCTTGACTTGAAAGGAATCGGCCCAGCTACCATC
  AAGAAATTGAAAGAAAATGGCATCAAGTTCAAGTAA
  60
  120
  180
  240
  300
  360
  396
  

⊟Protein

⊟General

• locus tag: SPP_RS02855 [old locus tag: SPP_0581 ]
• symbol: SPP_RS02855
• description: helicase
• length: 131
• theoretical pI: 10.8401
• theoretical MW: 14374.5
• GRAVY: -0.680916

⊟Function

• TIGRFAM:
  Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage tail tape measure protein, TP901 family, core region (TIGR01760; HMM-score: 18.4)
  and 4 more
  Cellular processes Cellular processes DNA transformation comEA protein (TIGR01259; HMM-score: 14.5)
  Metabolism Transport and binding proteins Amino acids, peptides and amines mitochondrial import inner membrane, translocase subunit (TIGR00984; HMM-score: 14.4)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA repair and recombination protein RadA (TIGR02236; HMM-score: 14.2)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis adenylosuccinate synthase (TIGR00184; EC 6.3.4.4; HMM-score: 12.4)
• TheSEED: see SPP_0581
• PFAM:
  no clan defined ApoLp-III; Apolipophorin-III precursor (apoLp-III) (PF07464; HMM-score: 22.6)
  HHH (CL0198) HHH_5; Helix-hairpin-helix domain (PF14520; HMM-score: 22.2)
  and 13 more
  HHH; Helix-hairpin-helix motif (PF00633; HMM-score: 16.9)
  no clan defined DUF763; Protein of unknown function (DUF763) (PF05559; HMM-score: 16.5)
  BAF; Barrier to autointegration factor (PF02961; HMM-score: 16.1)
  P-loop_NTPase (CL0023) Senescence; Senescence domain (PF06911; HMM-score: 16)
  no clan defined DBP; Duffy-antigen binding protein (PF12361; HMM-score: 15.1)
  VBS-like (CL0705) GCIP; Grap2 and cyclin-D-interacting (PF13324; HMM-score: 14.8)
  no clan defined Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin) (PF05597; HMM-score: 14.1)
  Met_repress (CL0057) DUF6364; Family of unknown function (DUF6364) (PF19891; HMM-score: 14)
  no clan defined DUF948; Bacterial protein of unknown function (DUF948) (PF06103; HMM-score: 12.7)
  C2H2-zf (CL0361) zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats (PF18868; HMM-score: 12.7)
  no clan defined Fib_alpha; Fibrinogen alpha/beta chain family (PF08702; HMM-score: 12.4)
  ATP_synthase (CL0255) ATP-synt_B; ATP synthase B/B' CF(0) (PF00430; HMM-score: 11.8)
  no clan defined YtxH; YtxH-like protein (PF12732; HMM-score: 10)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Extracellular
  • Cytoplasmic Score: 0.2161
  • Cytoplasmic Membrane Score: 0.198
  • Cell wall & surface Score: 0.146
  • Extracellular Score: 0.44
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.039684
  • TAT(Tat/SPI): 0.035315
  • LIPO(Sec/SPII): 0.007144
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000038627 NCBI
• UniProt:

⊟Protein sequence

• MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQTASAAGKAVSKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASHFKNWTEKELLDLKGIGPATIKKLKENGIKFK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPP_RS02840 > SPP_RS02845 > SPP_RS02850 > SPP_RS02855

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0490 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications